Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells

Optogenetic switches are emerging molecular tools for studying cellular processes as they offer higher spatiotemporal and quantitative precision than classical, chemical-based switches. Light-controllable gene expression systems designed to upregulate protein expression levels meanwhile show perform...

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Veröffentlicht in:	Scientific reports 2018-10, Vol.8 (1), p.15024-10, Article 15024
Hauptverfasser:	Baaske, Julia, Gonschorek, Patrick, Engesser, Raphael, Dominguez-Monedero, Alazne, Raute, Katrin, Fischbach, Patrick, Müller, Konrad, Cachat, Elise, Schamel, Wolfgang W. A., Minguet, Susana, Davies, Jamie A., Timmer, Jens, Weber, Wilfried, Zurbriggen, Matias D.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1511 631/1647/2253 631/337/572/2102 82 82/80 96 96/44 96/95 Animals Apoptosis Biodegradation Cell culture CHO Cells Cricetulus Gene expression Gene Expression Regulation - radiation effects Humanities and Social Sciences Illumination Kinases Light Light intensity Mammalian cells Mammals Mathematical models Models, Theoretical multidisciplinary Optogenetics - methods Photic Stimulation Protein Stability - radiation effects Proteins Proteolysis - radiation effects Repressor Proteins - genetics Science Science (multidisciplinary) Tissue engineering Transcriptional Activation - radiation effects
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