Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells

Misfolded toxic human islet amyloid polypeptide or amylin (hA) and plasma membrane-associated redox complex, NADPH oxidase (NOX), have been implicated in the islet β-cell demise associated with type-2 diabetes mellitus (T2DM). Studies show that hA accumulation is stressful to β-cells and that misfol...

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Veröffentlicht in:	Biochimica et biophysica acta. Biomembranes 2018-09, Vol.1860 (9), p.1721-1733
Hauptverfasser:	Singh, Sanghamitra, Bhowmick, Diti Chatterjee, Pany, Satyabrata, Joe, Myungkuk, Zaghlula, Noor, Jeremic, Aleksandar M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ASK-1 kinase Human amylin Human islets NADPH oxidase Oxidative stress Plasma membrane Type-2 diabetes mellitus
Online-Zugang:	Volltext
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