WDR5 Stabilizes Actin Architecture to Promote Multiciliated Cell Formation

The actin cytoskeleton is critical to shape cells and pattern intracellular organelles, which collectively drives tissue morphogenesis. In multiciliated cells (MCCs), apical actin drives expansion of the cell surface necessary to host hundreds of cilia. The apical actin also forms a lattice to unifo...

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Veröffentlicht in:	Developmental cell 2018-09, Vol.46 (5), p.595-610.e3
Hauptverfasser:	Kulkarni, Saurabh S., Griffin, John N., Date, Priya P., Liem, Karel F., Khokha, Mustafa K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - physiology Animals Basal Bodies - physiology basal body Cell Membrane - metabolism cilia Cilia - physiology congenital heart disease Embryo, Nonmammalian - cytology Embryo, Nonmammalian - physiology Female H3K4 histone modifier Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Humans Intracellular Signaling Peptides and Proteins Male methylation Mice Morphogenesis Xenopus
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