A 20(S)-protopanaxadiol derivative PPD12 reverses ABCB1-mediated multidrug resistance with oral bioavailability and low toxicity

The ATP-binding cassette subfamily B member 1 (ABCB1) is a transporter that mediates multidrug resistance (MDR) against chemotherapy, which leads to decreased patient survival. To inhibit ABCB1 activity in MDR cancer cells, the authors previously designed and synthesized a derivative from 20(S)-prot...

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Veröffentlicht in:	Oncology letters 2018-11, Vol.16 (5), p.5891-5899
Hauptverfasser:	Wei, Shunfeng, Chen, Wantao, Hu, Lihong, Pan, Jinsong, Wang, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Chemotherapy Females Herbal medicine Hormones Laboratory animals Males Medical research Metabolism Multidrug resistant organisms Researchers Rodents Studies
Online-Zugang:	Volltext
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