Targeting PDK4 inhibits breast cancer metabolism

Dysregulated metabolism in the form of aerobic glycolysis occurs in many cancers including breast carcinoma. Here, we report PDK4 (pyruvate dehydrogenase kinase 4) as key enzyme implicated in the control of glucose metabolism and mitochondrial respiration is relatively highly expressed in breast can...

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Veröffentlicht in:	American journal of cancer research 2018-01, Vol.8 (9), p.1725-1738
Hauptverfasser:	Guda, Maheedhara R, Asuthkar, Swapna, Labak, Collin M, Tsung, Andrew J, Alexandrov, Ilya, Mackenzie, Malcolm J, Prasad, Durbaka Vr, Velpula, Kiran K
Format:	Artikel
Sprache:	eng
Schlagworte:	Original
Online-Zugang:	Volltext
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