Visualising peripheral arterioles and venules through high-resolution and large-area photoacoustic imaging
Photoacoustic (PA) imaging (PAI) has been shown to be a promising tool for non-invasive blood vessel imaging. A PAI system comprising a hemispherical detector array (HDA) has been reported previously as a method providing high morphological reproducibility. However, further improvements in diagnosti...
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| Veröffentlicht in: | Scientific reports 2018-10, Vol.8 (1), p.14930-11, Article 14930 |
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| creator | Matsumoto, Yoshiaki Asao, Yasufumi Sekiguchi, Hiroyuki Yoshikawa, Aya Ishii, Tomoko Nagae, Ken-ichi Kobayashi, Shuichi Tsuge, Itaru Saito, Susumu Takada, Masahiro Ishida, Yoshihiro Kataoka, Masako Sakurai, Takaki Yagi, Takayuki Kabashima, Kenji Suzuki, Shigehiko Togashi, Kaori Shiina, Tsuyoshi Toi, Masakazu |
| description | Photoacoustic (PA) imaging (PAI) has been shown to be a promising tool for non-invasive blood vessel imaging. A PAI system comprising a hemispherical detector array (HDA) has been reported previously as a method providing high morphological reproducibility. However, further improvements in diagnostic capability will require improving the image quality of PAI and fusing functional and morphological imaging. Our newly developed PAI system prototype not only enhances the PA image resolution but also acquires ultrasonic (US) B-mode images at continuous positions in the same coordinate axes. In addition, the pulse-to-pulse alternating laser irradiation shortens the measurement time difference between two wavelengths. We scanned extremities and breasts in an imaging region 140 mm in diameter and obtained 3D-PA images of fine blood vessels, including arterioles and venules. We could estimate whether a vessel was an artery or a vein by using the S-factor obtained from the PA images at two wavelengths, which corresponds approximately to the haemoglobin oxygen saturation. Furthermore, we observed tumour-related blood vessels around breast tumours with unprecedented resolution. In the future, clinical studies with our new PAI system will help to elucidate various mechanisms of vascular-associated diseases and events. |
| doi_str_mv | 10.1038/s41598-018-33255-8 |
| format | Article |
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A PAI system comprising a hemispherical detector array (HDA) has been reported previously as a method providing high morphological reproducibility. However, further improvements in diagnostic capability will require improving the image quality of PAI and fusing functional and morphological imaging. Our newly developed PAI system prototype not only enhances the PA image resolution but also acquires ultrasonic (US) B-mode images at continuous positions in the same coordinate axes. In addition, the pulse-to-pulse alternating laser irradiation shortens the measurement time difference between two wavelengths. We scanned extremities and breasts in an imaging region 140 mm in diameter and obtained 3D-PA images of fine blood vessels, including arterioles and venules. We could estimate whether a vessel was an artery or a vein by using the S-factor obtained from the PA images at two wavelengths, which corresponds approximately to the haemoglobin oxygen saturation. Furthermore, we observed tumour-related blood vessels around breast tumours with unprecedented resolution. In the future, clinical studies with our new PAI system will help to elucidate various mechanisms of vascular-associated diseases and events.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-33255-8</identifier><identifier>PMID: 30297721</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59 ; 631/1647/245 ; 631/67/1347 ; Arterioles ; Blood vessels ; Breast cancer ; Extremities ; Hemoglobin ; Humanities and Social Sciences ; Image processing ; Irradiation ; Morphology ; multidisciplinary ; Science ; Science (multidisciplinary) ; Tumors ; Wavelengths</subject><ispartof>Scientific reports, 2018-10, Vol.8 (1), p.14930-11, Article 14930</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-d42ba2e8de1f030c2b00a3e67099ff8a95bb11917ef96d2459e8fa8fda1db95d3</citedby><cites>FETCH-LOGICAL-c584t-d42ba2e8de1f030c2b00a3e67099ff8a95bb11917ef96d2459e8fa8fda1db95d3</cites><orcidid>0000-0002-6210-5903 ; 0000-0002-4256-2349</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175891/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175891/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30297721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsumoto, Yoshiaki</creatorcontrib><creatorcontrib>Asao, Yasufumi</creatorcontrib><creatorcontrib>Sekiguchi, Hiroyuki</creatorcontrib><creatorcontrib>Yoshikawa, Aya</creatorcontrib><creatorcontrib>Ishii, Tomoko</creatorcontrib><creatorcontrib>Nagae, Ken-ichi</creatorcontrib><creatorcontrib>Kobayashi, Shuichi</creatorcontrib><creatorcontrib>Tsuge, Itaru</creatorcontrib><creatorcontrib>Saito, Susumu</creatorcontrib><creatorcontrib>Takada, Masahiro</creatorcontrib><creatorcontrib>Ishida, Yoshihiro</creatorcontrib><creatorcontrib>Kataoka, Masako</creatorcontrib><creatorcontrib>Sakurai, Takaki</creatorcontrib><creatorcontrib>Yagi, Takayuki</creatorcontrib><creatorcontrib>Kabashima, Kenji</creatorcontrib><creatorcontrib>Suzuki, Shigehiko</creatorcontrib><creatorcontrib>Togashi, Kaori</creatorcontrib><creatorcontrib>Shiina, Tsuyoshi</creatorcontrib><creatorcontrib>Toi, Masakazu</creatorcontrib><title>Visualising peripheral arterioles and venules through high-resolution and large-area photoacoustic imaging</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Photoacoustic (PA) imaging (PAI) has been shown to be a promising tool for non-invasive blood vessel imaging. A PAI system comprising a hemispherical detector array (HDA) has been reported previously as a method providing high morphological reproducibility. However, further improvements in diagnostic capability will require improving the image quality of PAI and fusing functional and morphological imaging. Our newly developed PAI system prototype not only enhances the PA image resolution but also acquires ultrasonic (US) B-mode images at continuous positions in the same coordinate axes. In addition, the pulse-to-pulse alternating laser irradiation shortens the measurement time difference between two wavelengths. We scanned extremities and breasts in an imaging region 140 mm in diameter and obtained 3D-PA images of fine blood vessels, including arterioles and venules. We could estimate whether a vessel was an artery or a vein by using the S-factor obtained from the PA images at two wavelengths, which corresponds approximately to the haemoglobin oxygen saturation. Furthermore, we observed tumour-related blood vessels around breast tumours with unprecedented resolution. In the future, clinical studies with our new PAI system will help to elucidate various mechanisms of vascular-associated diseases and events.</description><subject>59</subject><subject>631/1647/245</subject><subject>631/67/1347</subject><subject>Arterioles</subject><subject>Blood vessels</subject><subject>Breast cancer</subject><subject>Extremities</subject><subject>Hemoglobin</subject><subject>Humanities and Social Sciences</subject><subject>Image processing</subject><subject>Irradiation</subject><subject>Morphology</subject><subject>multidisciplinary</subject><subject>Science</subject><subject>Science 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Shigehiko</au><au>Togashi, Kaori</au><au>Shiina, Tsuyoshi</au><au>Toi, Masakazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visualising peripheral arterioles and venules through high-resolution and large-area photoacoustic imaging</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-10-08</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>14930</spage><epage>11</epage><pages>14930-11</pages><artnum>14930</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Photoacoustic (PA) imaging (PAI) has been shown to be a promising tool for non-invasive blood vessel imaging. A PAI system comprising a hemispherical detector array (HDA) has been reported previously as a method providing high morphological reproducibility. However, further improvements in diagnostic capability will require improving the image quality of PAI and fusing functional and morphological imaging. Our newly developed PAI system prototype not only enhances the PA image resolution but also acquires ultrasonic (US) B-mode images at continuous positions in the same coordinate axes. In addition, the pulse-to-pulse alternating laser irradiation shortens the measurement time difference between two wavelengths. We scanned extremities and breasts in an imaging region 140 mm in diameter and obtained 3D-PA images of fine blood vessels, including arterioles and venules. We could estimate whether a vessel was an artery or a vein by using the S-factor obtained from the PA images at two wavelengths, which corresponds approximately to the haemoglobin oxygen saturation. Furthermore, we observed tumour-related blood vessels around breast tumours with unprecedented resolution. In the future, clinical studies with our new PAI system will help to elucidate various mechanisms of vascular-associated diseases and events.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30297721</pmid><doi>10.1038/s41598-018-33255-8</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6210-5903</orcidid><orcidid>https://orcid.org/0000-0002-4256-2349</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 59 631/1647/245 631/67/1347 Arterioles Blood vessels Breast cancer Extremities Hemoglobin Humanities and Social Sciences Image processing Irradiation Morphology multidisciplinary Science Science (multidisciplinary) Tumors Wavelengths |
| title | Visualising peripheral arterioles and venules through high-resolution and large-area photoacoustic imaging |
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