Impact of contrast agent injection duration on dynamic contrast‐enhanced MRI quantification in prostate cancer
The volume transfer constant Ktrans, which describes the leakage of contrast agent (CA) from vasculature into tissue, is the most commonly reported quantitative parameter for dynamic contrast‐enhanced (DCE‐) MRI. However, the variation in reported Ktrans values between studies from different institu...
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| Veröffentlicht in: | NMR in biomedicine 2018-09, Vol.31 (9), p.e3946-n/a |
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| creator | Klawer, Edzo M.E. Houdt, Petra J. Pos, Floris J. Heijmink, Stijn W.T.P.J. Osch, Matthias J.P. Heide, Uulke A. |
| description | The volume transfer constant Ktrans, which describes the leakage of contrast agent (CA) from vasculature into tissue, is the most commonly reported quantitative parameter for dynamic contrast‐enhanced (DCE‐) MRI. However, the variation in reported Ktrans values between studies from different institutes is large. One of the primary sources of uncertainty is quantification of the arterial input function (AIF). The aim of this study is to determine the influence of the CA injection duration on the AIF and tracer kinetic analysis (TKA) parameters (i.e. Ktrans, kep and ve).
Thirty‐one patients with prostate cancer received two DCE‐MRI examinations with an injection duration of 5 s in the first examination and a prolonged injection duration in the second examination, varying between 7.5 s and 30 s. The DCE examination was carried out on a 3.0 T MRI scanner using a transversal T1‐weighted 3D spoiled gradient echo sequence (300 s duration, dynamic scan time of 2.5 s). Data of 29 of the 31 were further analysed. AIFs were determined from the phase signal in the left and right femoral arteries. Ktrans, kep and ve were estimated with the standard Tofts model for regions of healthy peripheral zone and tumour tissue.
We observed a significantly smaller peak height and increased width in the AIF for injection durations of 15 s and longer. However, we did not find significant differences in Ktrans, kep or ve for the studied injection durations. The study demonstrates that the TKA parameters Ktrans, kep and ve, measured in the prostate, do not show a significant change as a function of injection duration.
This study investigates the influence of injection duration of contrast agent on the quantification of DCE‐MRI. For longer durations (≥15 s) the peak of the arterial input function became lower and the width was larger. However, no significant difference in tracer kinetic parameter values was found in healthy or tumour prostate tissue. |
| doi_str_mv | 10.1002/nbm.3946 |
| format | Article |
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Thirty‐one patients with prostate cancer received two DCE‐MRI examinations with an injection duration of 5 s in the first examination and a prolonged injection duration in the second examination, varying between 7.5 s and 30 s. The DCE examination was carried out on a 3.0 T MRI scanner using a transversal T1‐weighted 3D spoiled gradient echo sequence (300 s duration, dynamic scan time of 2.5 s). Data of 29 of the 31 were further analysed. AIFs were determined from the phase signal in the left and right femoral arteries. Ktrans, kep and ve were estimated with the standard Tofts model for regions of healthy peripheral zone and tumour tissue.
We observed a significantly smaller peak height and increased width in the AIF for injection durations of 15 s and longer. However, we did not find significant differences in Ktrans, kep or ve for the studied injection durations. The study demonstrates that the TKA parameters Ktrans, kep and ve, measured in the prostate, do not show a significant change as a function of injection duration.
This study investigates the influence of injection duration of contrast agent on the quantification of DCE‐MRI. For longer durations (≥15 s) the peak of the arterial input function became lower and the width was larger. However, no significant difference in tracer kinetic parameter values was found in healthy or tumour prostate tissue.</description><identifier>ISSN: 0952-3480</identifier><identifier>EISSN: 1099-1492</identifier><identifier>DOI: 10.1002/nbm.3946</identifier><identifier>PMID: 29974981</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Aged, 80 and over ; Area Under Curve ; arterial input function ; Arteries ; Arteries - diagnostic imaging ; Arteries - physiopathology ; Biological products ; Cancer ; contrast agent ; Contrast agents ; Contrast Media - chemistry ; Contrast Media - pharmacokinetics ; dynamic contrast‐enhanced MRI ; Femoral artery ; Femur ; Humans ; Injection ; injection protocol ; Injections ; Kinetics ; Ktrans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Parameters ; phase signal ; Prostate cancer ; Prostatic Neoplasms - diagnostic imaging ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - physiopathology ; tracer kinetic analysis ; Tumors</subject><ispartof>NMR in biomedicine, 2018-09, Vol.31 (9), p.e3946-n/a</ispartof><rights>2018 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2018 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.</rights><rights>2018 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4386-6f3b8689718bba9c5c14b0a21500558ff0d47a65f699dd0e16adfea7665a292f3</citedby><cites>FETCH-LOGICAL-c4386-6f3b8689718bba9c5c14b0a21500558ff0d47a65f699dd0e16adfea7665a292f3</cites><orcidid>0000-0001-9882-2149</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fnbm.3946$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fnbm.3946$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29974981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klawer, Edzo M.E.</creatorcontrib><creatorcontrib>Houdt, Petra J.</creatorcontrib><creatorcontrib>Pos, Floris J.</creatorcontrib><creatorcontrib>Heijmink, Stijn W.T.P.J.</creatorcontrib><creatorcontrib>Osch, Matthias J.P.</creatorcontrib><creatorcontrib>Heide, Uulke A.</creatorcontrib><title>Impact of contrast agent injection duration on dynamic contrast‐enhanced MRI quantification in prostate cancer</title><title>NMR in biomedicine</title><addtitle>NMR Biomed</addtitle><description>The volume transfer constant Ktrans, which describes the leakage of contrast agent (CA) from vasculature into tissue, is the most commonly reported quantitative parameter for dynamic contrast‐enhanced (DCE‐) MRI. However, the variation in reported Ktrans values between studies from different institutes is large. One of the primary sources of uncertainty is quantification of the arterial input function (AIF). The aim of this study is to determine the influence of the CA injection duration on the AIF and tracer kinetic analysis (TKA) parameters (i.e. Ktrans, kep and ve).
Thirty‐one patients with prostate cancer received two DCE‐MRI examinations with an injection duration of 5 s in the first examination and a prolonged injection duration in the second examination, varying between 7.5 s and 30 s. The DCE examination was carried out on a 3.0 T MRI scanner using a transversal T1‐weighted 3D spoiled gradient echo sequence (300 s duration, dynamic scan time of 2.5 s). Data of 29 of the 31 were further analysed. AIFs were determined from the phase signal in the left and right femoral arteries. Ktrans, kep and ve were estimated with the standard Tofts model for regions of healthy peripheral zone and tumour tissue.
We observed a significantly smaller peak height and increased width in the AIF for injection durations of 15 s and longer. However, we did not find significant differences in Ktrans, kep or ve for the studied injection durations. The study demonstrates that the TKA parameters Ktrans, kep and ve, measured in the prostate, do not show a significant change as a function of injection duration.
This study investigates the influence of injection duration of contrast agent on the quantification of DCE‐MRI. For longer durations (≥15 s) the peak of the arterial input function became lower and the width was larger. However, no significant difference in tracer kinetic parameter values was found in healthy or tumour prostate tissue.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Area Under Curve</subject><subject>arterial input function</subject><subject>Arteries</subject><subject>Arteries - diagnostic imaging</subject><subject>Arteries - physiopathology</subject><subject>Biological products</subject><subject>Cancer</subject><subject>contrast agent</subject><subject>Contrast agents</subject><subject>Contrast Media - chemistry</subject><subject>Contrast Media - pharmacokinetics</subject><subject>dynamic contrast‐enhanced MRI</subject><subject>Femoral artery</subject><subject>Femur</subject><subject>Humans</subject><subject>Injection</subject><subject>injection protocol</subject><subject>Injections</subject><subject>Kinetics</subject><subject>Ktrans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parameters</subject><subject>phase signal</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - diagnostic imaging</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - physiopathology</subject><subject>tracer kinetic analysis</subject><subject>Tumors</subject><issn>0952-3480</issn><issn>1099-1492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kdFO2zAUhi0Ego4h8QTIEje7SbGd2IlvkEYFWyW6SdN2bZ04NrhqnNRxmHrHI_CMe5IlLavYBVc-kj9__o9-hM4pmVJC2JUv62kqM3GAJpRImdBMskM0IZKzJM0KcoI-dN2SEFJkKTtGJ0zKPJMFnaB2XregI24s1o2PAbqI4cH4iJ1fGh1d43HVB9gO47zxUDu9h_88vxj_CF6bCi9-zPG6Bx-ddXr3wnnchqaLEA3WIxU-oiMLq86cvZ6n6Nfd7c_Z1-T--5f57PN9orO0EImwaVmIQua0KEuQmmualQQY5YRwXlhLqiwHwa2QsqqIoQIqayAXggOTzKan6HrnbfuyNpU2Y96VaoOrIWxUA079f-Pdo3ponpSgOU85HwSXr4LQrHvTRbVs-uCHzIoRyYaQeU4H6tOO0sOaXTB2_wMlauxGDd2osZsBvXibaA_-K2MAkh3w263M5l2R-naz2Ar_AmKcnAc</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Klawer, Edzo M.E.</creator><creator>Houdt, Petra J.</creator><creator>Pos, Floris J.</creator><creator>Heijmink, Stijn W.T.P.J.</creator><creator>Osch, Matthias J.P.</creator><creator>Heide, Uulke A.</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9882-2149</orcidid></search><sort><creationdate>201809</creationdate><title>Impact of contrast agent injection duration on dynamic contrast‐enhanced MRI quantification in prostate cancer</title><author>Klawer, Edzo M.E. ; Houdt, Petra J. ; Pos, Floris J. ; Heijmink, Stijn W.T.P.J. ; Osch, Matthias J.P. ; Heide, Uulke A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4386-6f3b8689718bba9c5c14b0a21500558ff0d47a65f699dd0e16adfea7665a292f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Area Under Curve</topic><topic>arterial input function</topic><topic>Arteries</topic><topic>Arteries - diagnostic imaging</topic><topic>Arteries - physiopathology</topic><topic>Biological products</topic><topic>Cancer</topic><topic>contrast agent</topic><topic>Contrast agents</topic><topic>Contrast Media - chemistry</topic><topic>Contrast Media - pharmacokinetics</topic><topic>dynamic contrast‐enhanced MRI</topic><topic>Femoral artery</topic><topic>Femur</topic><topic>Humans</topic><topic>Injection</topic><topic>injection protocol</topic><topic>Injections</topic><topic>Kinetics</topic><topic>Ktrans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Parameters</topic><topic>phase signal</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - diagnostic imaging</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - physiopathology</topic><topic>tracer kinetic analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klawer, Edzo M.E.</creatorcontrib><creatorcontrib>Houdt, Petra J.</creatorcontrib><creatorcontrib>Pos, Floris J.</creatorcontrib><creatorcontrib>Heijmink, Stijn W.T.P.J.</creatorcontrib><creatorcontrib>Osch, Matthias J.P.</creatorcontrib><creatorcontrib>Heide, Uulke A.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>NMR in biomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klawer, Edzo M.E.</au><au>Houdt, Petra J.</au><au>Pos, Floris J.</au><au>Heijmink, Stijn W.T.P.J.</au><au>Osch, Matthias J.P.</au><au>Heide, Uulke A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of contrast agent injection duration on dynamic contrast‐enhanced MRI quantification in prostate cancer</atitle><jtitle>NMR in biomedicine</jtitle><addtitle>NMR Biomed</addtitle><date>2018-09</date><risdate>2018</risdate><volume>31</volume><issue>9</issue><spage>e3946</spage><epage>n/a</epage><pages>e3946-n/a</pages><issn>0952-3480</issn><eissn>1099-1492</eissn><abstract>The volume transfer constant Ktrans, which describes the leakage of contrast agent (CA) from vasculature into tissue, is the most commonly reported quantitative parameter for dynamic contrast‐enhanced (DCE‐) MRI. However, the variation in reported Ktrans values between studies from different institutes is large. One of the primary sources of uncertainty is quantification of the arterial input function (AIF). The aim of this study is to determine the influence of the CA injection duration on the AIF and tracer kinetic analysis (TKA) parameters (i.e. Ktrans, kep and ve).
Thirty‐one patients with prostate cancer received two DCE‐MRI examinations with an injection duration of 5 s in the first examination and a prolonged injection duration in the second examination, varying between 7.5 s and 30 s. The DCE examination was carried out on a 3.0 T MRI scanner using a transversal T1‐weighted 3D spoiled gradient echo sequence (300 s duration, dynamic scan time of 2.5 s). Data of 29 of the 31 were further analysed. AIFs were determined from the phase signal in the left and right femoral arteries. Ktrans, kep and ve were estimated with the standard Tofts model for regions of healthy peripheral zone and tumour tissue.
We observed a significantly smaller peak height and increased width in the AIF for injection durations of 15 s and longer. However, we did not find significant differences in Ktrans, kep or ve for the studied injection durations. The study demonstrates that the TKA parameters Ktrans, kep and ve, measured in the prostate, do not show a significant change as a function of injection duration.
This study investigates the influence of injection duration of contrast agent on the quantification of DCE‐MRI. For longer durations (≥15 s) the peak of the arterial input function became lower and the width was larger. However, no significant difference in tracer kinetic parameter values was found in healthy or tumour prostate tissue.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29974981</pmid><doi>10.1002/nbm.3946</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9882-2149</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Area Under Curve arterial input function Arteries Arteries - diagnostic imaging Arteries - physiopathology Biological products Cancer contrast agent Contrast agents Contrast Media - chemistry Contrast Media - pharmacokinetics dynamic contrast‐enhanced MRI Femoral artery Femur Humans Injection injection protocol Injections Kinetics Ktrans Magnetic Resonance Imaging Male Middle Aged Parameters phase signal Prostate cancer Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - pathology Prostatic Neoplasms - physiopathology tracer kinetic analysis Tumors |
| title | Impact of contrast agent injection duration on dynamic contrast‐enhanced MRI quantification in prostate cancer |
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