Randomized controlled trials define shape of dose response for Pollinex Quattro Birch allergoid immunotherapy

Background The Birch Allergoid, Tyrosine Adsorbate, Monophosphoryl Lipid A (POLLINEX® Quattro Plus 1.0 ml Birch 100%) is an effective, well‐tolerated short course subcutaneous immunotherapy. We performed 2 phase II studies to determine its optimal cumulative dose. Methods The studies were conducted...

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Veröffentlicht in:	Allergy (Copenhagen) 2018-09, Vol.73 (9), p.1812-1822
Hauptverfasser:	Worm, M., Higenbottam, T., Pfaar, O., Mösges, R., Aberer, W., Gunawardena, K., Wessiepe, D., Lee, D., Kramer, M. F., Skinner, M., Lees, B., Zielen, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adsorbates Adult allergen immunotherapy Allergens - immunology Allergoids Austria Betula - adverse effects birch pollen allergoid cumulative dose Desensitization, Immunologic - adverse effects Desensitization, Immunologic - methods dose response curve Dose-Response Relationship, Immunologic Drug Administration Schedule Evidence-based medicine Female Germany Humans Immunotherapy Lipid A Male Middle Aged Monophosphoryl lipid A Original ORIGINAL ARTICLES Plant Extracts - administration & dosage Plant Extracts - immunology Poland Pollen Pollen - immunology Provocation tests Rhinitis, Allergic, Seasonal - diagnosis Rhinitis, Allergic, Seasonal - immunology Rhinitis, Allergic, Seasonal - therapy Statistical analysis Treatment Outcome Tyrosine Vaccines - administration & dosage Vaccines - immunology Young Adult
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