Molecular progression to cervical precancer, epigenetic switch or sequential model?

The evolution of precancerous cervical lesions is poorly understood. A widely held model of cervical intraepithelial neoplasia grade 3 (CIN3) development is sequential progression from normal through CIN1 and CIN2 to CIN3. Another hypothesis, the “molecular switch” model, postulates that CIN3 can ev...

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Veröffentlicht in:	International journal of cancer 2018-10, Vol.143 (7), p.1720-1730
Hauptverfasser:	Nedjai, Belinda, Reuter, Caroline, Ahmad, Amar, Banwait, Rawinder, Warman, Rhian, Carton, James, Boer, Sabrina, Cuzick, Jack, Lorincz, Attila T.
Format:	Artikel
Sprache:	eng
Schlagworte:	biomarker Biomarkers, Tumor - genetics Bisulfite Cancer Cancer Genetics and Epigenetics Cervical cancer cervical intraepithelial neoplasia (CIN) Cervix Uteri - metabolism Cervix Uteri - pathology Cervix Uteri - virology Deoxyribonucleic acid Disease Progression DNA DNA Methylation Epigenomics epigenotype Epithelium Female Follow-Up Studies Gene Expression Regulation, Neoplastic HPV typing Human papillomavirus Humans Lesions Medical research methylation Molecular machines molecular switch Papillomaviridae - isolation & purification Papillomavirus Infections - complications Papillomavirus Infections - genetics Papillomavirus Infections - virology Pilot Projects Prognosis Risk Factors sequential progression Uterine Cervical Dysplasia - genetics Uterine Cervical Dysplasia - pathology Uterine Cervical Dysplasia - virology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - virology
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