Clinical trials in allergen immunotherapy: current concepts and future needs

Allergen immunotherapy (AIT) is a safe, effective treatment for allergic rhinoconjunctivitis and allergic asthma. However, AIT's clinical effect is still contested—primarily due to heterogeneity in clinical trial designs, study populations, therapeutic formulations, and efficacy criteria. After...

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Veröffentlicht in:	Allergy (Copenhagen) 2018-09, Vol.73 (9), p.1775-1783
Hauptverfasser:	Pfaar, O., Alvaro, M., Cardona, V., Hamelmann, E., Mösges, R., Kleine‐Tebbe, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	allergen immunotherapy Allergens Allergens - immunology allergic asthma allergic rhinoconjunctivitis Allergies Animals Asthma Children clinical development Clinical trials Clinical Trials as Topic Consensus Desensitization, Immunologic - adverse effects Desensitization, Immunologic - methods Disease Management Expert Testimony Exposure Formulations Heterogeneity Humans Hypersensitivity - diagnosis Hypersensitivity - immunology Hypersensitivity - therapy Immunotherapy Medical personnel Patients Population studies Provocation tests Regulators Regulatory agencies Review Rhinoconjunctivitis Treatment Outcome trial design
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