POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy
POxylated polyurea dendrimer (PUREG4OOx48)‐based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2‐assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced...
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| Veröffentlicht in: | ChemistryOpen (Weinheim) 2018-10, Vol.7 (10), p.772-779 |
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| creator | Restani, Rita B. Pires, Rita F. Tolmatcheva, Anna Cabral, Rita Baptista, Pedro V. Fernandes, Alexandra R. Casimiro, Teresa Bonifácio, Vasco D. B. Aguiar‐Ricardo, Ana |
| description | POxylated polyurea dendrimer (PUREG4OOx48)‐based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2‐assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX‐DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.
Inhalation chemotherapeutics: Micronized POxylated polyurea dendrimers loaded with anticancer agents (paclitaxel or doxorubicin) are fabricated by using green methodologies. These drug‐delivery systems reveal enhanced drug accumulation into neoplastic cells and allow a reduction in drug dosages and undesired side effects. |
| doi_str_mv | 10.1002/open.201800093 |
| format | Article |
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Inhalation chemotherapeutics: Micronized POxylated polyurea dendrimers loaded with anticancer agents (paclitaxel or doxorubicin) are fabricated by using green methodologies. These drug‐delivery systems reveal enhanced drug accumulation into neoplastic cells and allow a reduction in drug dosages and undesired side effects.</description><identifier>ISSN: 2191-1363</identifier><identifier>EISSN: 2191-1363</identifier><identifier>DOI: 10.1002/open.201800093</identifier><identifier>PMID: 30338202</identifier><language>eng</language><publisher>Germany: John Wiley & Sons, Inc</publisher><subject>Biocompatibility ; Biodegradability ; Chemotherapy ; Chitosan ; composite particles ; dendrimers ; Doxorubicin ; drug delivery ; Formulations ; Nanoparticles ; pulmonary delivery ; Respiration ; Spray drying ; Toxicity</subject><ispartof>ChemistryOpen (Weinheim), 2018-10, Vol.7 (10), p.772-779</ispartof><rights>2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5053-ea6df8e3b6001b6c34a9f1af124a637139e1316da0594dcefd3710e054a8b22a3</citedby><cites>FETCH-LOGICAL-c5053-ea6df8e3b6001b6c34a9f1af124a637139e1316da0594dcefd3710e054a8b22a3</cites><orcidid>0000-0003-2741-8100 ; 0000-0003-2349-8473 ; 0000-0001-9405-6221 ; 0000-0003-3678-1462 ; 0000-0003-2054-4438 ; 0000-0001-5255-7095 ; 0000-0002-2193-1440</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174550/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174550/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30338202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Restani, Rita B.</creatorcontrib><creatorcontrib>Pires, Rita F.</creatorcontrib><creatorcontrib>Tolmatcheva, Anna</creatorcontrib><creatorcontrib>Cabral, Rita</creatorcontrib><creatorcontrib>Baptista, Pedro V.</creatorcontrib><creatorcontrib>Fernandes, Alexandra R.</creatorcontrib><creatorcontrib>Casimiro, Teresa</creatorcontrib><creatorcontrib>Bonifácio, Vasco D. B.</creatorcontrib><creatorcontrib>Aguiar‐Ricardo, Ana</creatorcontrib><title>POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy</title><title>ChemistryOpen (Weinheim)</title><addtitle>ChemistryOpen</addtitle><description>POxylated polyurea dendrimer (PUREG4OOx48)‐based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2‐assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX‐DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.
Inhalation chemotherapeutics: Micronized POxylated polyurea dendrimers loaded with anticancer agents (paclitaxel or doxorubicin) are fabricated by using green methodologies. These drug‐delivery systems reveal enhanced drug accumulation into neoplastic cells and allow a reduction in drug dosages and undesired side effects.</description><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Chemotherapy</subject><subject>Chitosan</subject><subject>composite particles</subject><subject>dendrimers</subject><subject>Doxorubicin</subject><subject>drug delivery</subject><subject>Formulations</subject><subject>Nanoparticles</subject><subject>pulmonary delivery</subject><subject>Respiration</subject><subject>Spray drying</subject><subject>Toxicity</subject><issn>2191-1363</issn><issn>2191-1363</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkcFOGzEQhi3UChDl2iNaiUsvScf22slekCBAi0RJDvRsTXZnyaJdO9hZYG88As_Ik9Sr0EB74eLxjL_5NeOfsa8chhxAfHdLskMBfAwAmdxiu4JnfMCllp_e3XfYfgi3EYFRmnGlt9mOBCnHAsQuw9n0satxRUVySrbwVUP-5en5BEOsXKF1MalsPH5VuXfJqe-SmXsoyCfnzjdt7KycDUnpfHJhF7jOk8mCGrdakMdl94V9LrEOtP8a99jv87Pryc_B5fTHxeT4cpArUHJAqItyTHKuAfhc5zLFrORYcpGiliMuM-KS6wJBZWmRU1nEIhCoFMdzIVDusaO17rKdNxQJu_JYm2VcCX1nHFbm3xdbLcyNuzeaj1KlIAp8exXw7q6lsDJNFXKqa7Tk2mAEF_0cOlMRPfwPvXWtt3G9nlIiHYHoqeGaij8XgqdyMwwH0xtoegPNxsDYcPB-hQ3-164IZGvgoaqp-0DOTGdnV2_ifwAwLatY</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Restani, Rita B.</creator><creator>Pires, Rita F.</creator><creator>Tolmatcheva, Anna</creator><creator>Cabral, Rita</creator><creator>Baptista, Pedro V.</creator><creator>Fernandes, Alexandra R.</creator><creator>Casimiro, Teresa</creator><creator>Bonifácio, Vasco D. 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B.</au><au>Aguiar‐Ricardo, Ana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy</atitle><jtitle>ChemistryOpen (Weinheim)</jtitle><addtitle>ChemistryOpen</addtitle><date>2018-10</date><risdate>2018</risdate><volume>7</volume><issue>10</issue><spage>772</spage><epage>779</epage><pages>772-779</pages><issn>2191-1363</issn><eissn>2191-1363</eissn><abstract>POxylated polyurea dendrimer (PUREG4OOx48)‐based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2‐assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX‐DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.
Inhalation chemotherapeutics: Micronized POxylated polyurea dendrimers loaded with anticancer agents (paclitaxel or doxorubicin) are fabricated by using green methodologies. These drug‐delivery systems reveal enhanced drug accumulation into neoplastic cells and allow a reduction in drug dosages and undesired side effects.</abstract><cop>Germany</cop><pub>John Wiley & Sons, Inc</pub><pmid>30338202</pmid><doi>10.1002/open.201800093</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2741-8100</orcidid><orcidid>https://orcid.org/0000-0003-2349-8473</orcidid><orcidid>https://orcid.org/0000-0001-9405-6221</orcidid><orcidid>https://orcid.org/0000-0003-3678-1462</orcidid><orcidid>https://orcid.org/0000-0003-2054-4438</orcidid><orcidid>https://orcid.org/0000-0001-5255-7095</orcidid><orcidid>https://orcid.org/0000-0002-2193-1440</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biocompatibility Biodegradability Chemotherapy Chitosan composite particles dendrimers Doxorubicin drug delivery Formulations Nanoparticles pulmonary delivery Respiration Spray drying Toxicity |
| title | POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy |
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