Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure

Excretion of albumin in urine, or albuminuria, is associated with the development of multiple cardiovascular and metabolic diseases. However, whether pathways leading to albuminuria are causal for cardiometabolic diseases is unclear. We addressed this question using a Mendelian randomization framewo...

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Veröffentlicht in:	American journal of human genetics 2018-10, Vol.103 (4), p.461-473
Hauptverfasser:	Haas, Mary E., Aragam, Krishna G., Emdin, Connor A., Bick, Alexander G., Hemani, Gibran, Davey Smith, George, Kathiresan, Sekar
Format:	Artikel
Sprache:	eng
Schlagworte:	albuminuria Albuminuria - genetics blood pressure Blood Pressure - genetics cardiometabolic disease cardiovascular disease Cardiovascular Diseases - genetics Female genetic risk score genome-wide association study Genome-Wide Association Study - methods Humans hypertension Hypertension - genetics Male Mendelian randomization Metabolic Diseases - genetics Middle Aged polygenic risk score Risk Factors urine albumin excretion urine albumin:creatinine ratio
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