Inflammation, adiposity, and progression of arterial stiffness in adolescents with type 1 diabetes: The SEARCH CVD Study
We examined the association between inflammation and progression of arterial stiffness in a population of youth with type 1 diabetes (T1D). A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammat...
Gespeichert in:
| Veröffentlicht in: | Journal of diabetes and its complications 2018-11, Vol.32 (11), p.995-999 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 999 |
|---|---|
| container_issue | 11 |
| container_start_page | 995 |
| container_title | Journal of diabetes and its complications |
| container_volume | 32 |
| creator | Alman, Amy C. Talton, Jennifer W. Wadwa, R. Paul Urbina, Elaine M. Dolan, Lawrence M. Hamman, Richard F. D'Agostino, Ralph B. Marcovina, Santica M. Dabelea, Dana M. |
| description | We examined the association between inflammation and progression of arterial stiffness in a population of youth with type 1 diabetes (T1D).
A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammation (CRP, IL-6, fibrinogen, leptin, and adiponectin) and measures of pulse wave velocity (PWV) of the arm (PWV-R), trunk (PWV-T), and lower extremity (PWV-LE) were measured at baseline. Measures of PWV were repeated approximately five years later.
PWV-R (0.50 m/s), PWV-T (0.65 m/s), and PWV-LE (1.0 m/s) significantly increased over the follow-up (p |
| doi_str_mv | 10.1016/j.jdiacomp.2018.08.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6174105</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1056872717305470</els_id><sourcerecordid>2116009072</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-ff686a83f488282e324cfaf085c6a7ac1befaaae86125add2abacabdc5a182ea3</originalsourceid><addsrcrecordid>eNqFkVFrFDEQxxdRbK1-hRLwxQf3TLK72ZwPYjmrLRQEW8W3MJud9LLsJmuSq71v3xzXFvVFGMjA_zeTmfkXxTGjC0aZeDcsht6C9tO84JTJBc1B6yfFIZNtVdaC_nyac9qIUra8PShexDhQSkXTsOfFQUU5XVK2PCxuz50ZYZogWe_eEujt7KNN25y6nszBXweMMWvEGwIhYbAwkpisMS4LxLpc40eMGl2K5LdNa5K2MxJG8nwdJozvydUayeXpybfVGVn9-EQu06bfviyeGRgjvrp_j4rvn0-vVmflxdcv56uTi1LXy2UqjRFSgKxMLSWXHCteawOGykYLaEGzDg0AoBSMN9D3HDrQ0PW6AZZxqI6KD_u-86absN-NGWBUc7AThK3yYNXfirNrde1vlGBtnQ-YG7y5bxD8rw3GpCabtx1HcOg3UXFGK9E2FWMZff0POvhNcHm9TDFB881bnimxp3TwMQY0j8MwqnbmqkE9mKt25iqag9a58PjPVR7LHtzMwMc9gPmgNxaDitqi09jbgDqp3tv__XEH8_C77g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2116009072</pqid></control><display><type>article</type><title>Inflammation, adiposity, and progression of arterial stiffness in adolescents with type 1 diabetes: The SEARCH CVD Study</title><source>Elsevier ScienceDirect Journals</source><creator>Alman, Amy C. ; Talton, Jennifer W. ; Wadwa, R. Paul ; Urbina, Elaine M. ; Dolan, Lawrence M. ; Hamman, Richard F. ; D'Agostino, Ralph B. ; Marcovina, Santica M. ; Dabelea, Dana M.</creator><creatorcontrib>Alman, Amy C. ; Talton, Jennifer W. ; Wadwa, R. Paul ; Urbina, Elaine M. ; Dolan, Lawrence M. ; Hamman, Richard F. ; D'Agostino, Ralph B. ; Marcovina, Santica M. ; Dabelea, Dana M.</creatorcontrib><description>We examined the association between inflammation and progression of arterial stiffness in a population of youth with type 1 diabetes (T1D).
A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammation (CRP, IL-6, fibrinogen, leptin, and adiponectin) and measures of pulse wave velocity (PWV) of the arm (PWV-R), trunk (PWV-T), and lower extremity (PWV-LE) were measured at baseline. Measures of PWV were repeated approximately five years later.
PWV-R (0.50 m/s), PWV-T (0.65 m/s), and PWV-LE (1.0 m/s) significantly increased over the follow-up (p < 0.001 for each). A significant interaction was found between waist circumference and fibrinogen (p = 0.036) on the progression of PWV-T, suggesting that fibrinogen is more strongly associated with PWV progression in lean participants.
Improved understanding of adiposity, inflammation, and functional changes in the vascular system in patients with T1D is crucial.</description><identifier>ISSN: 1056-8727</identifier><identifier>EISSN: 1873-460X</identifier><identifier>DOI: 10.1016/j.jdiacomp.2018.08.004</identifier><identifier>PMID: 30209019</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age ; Arterial stiffness ; Atherosclerosis ; Cardiovascular disease ; Cholesterol ; Cytokines ; Diabetes ; Fibrinogen ; Inflammation ; Insulin resistance ; Laboratories ; Lipoproteins ; Metabolism ; Population ; Proteins ; Pulse wave analysis ; Teenagers ; Triglycerides ; Type 1 diabetes mellitus ; Waist circumference ; Young adults</subject><ispartof>Journal of diabetes and its complications, 2018-11, Vol.32 (11), p.995-999</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-ff686a83f488282e324cfaf085c6a7ac1befaaae86125add2abacabdc5a182ea3</citedby><cites>FETCH-LOGICAL-c499t-ff686a83f488282e324cfaf085c6a7ac1befaaae86125add2abacabdc5a182ea3</cites><orcidid>0000-0003-3609-2595</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1056872717305470$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30209019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alman, Amy C.</creatorcontrib><creatorcontrib>Talton, Jennifer W.</creatorcontrib><creatorcontrib>Wadwa, R. Paul</creatorcontrib><creatorcontrib>Urbina, Elaine M.</creatorcontrib><creatorcontrib>Dolan, Lawrence M.</creatorcontrib><creatorcontrib>Hamman, Richard F.</creatorcontrib><creatorcontrib>D'Agostino, Ralph B.</creatorcontrib><creatorcontrib>Marcovina, Santica M.</creatorcontrib><creatorcontrib>Dabelea, Dana M.</creatorcontrib><title>Inflammation, adiposity, and progression of arterial stiffness in adolescents with type 1 diabetes: The SEARCH CVD Study</title><title>Journal of diabetes and its complications</title><addtitle>J Diabetes Complications</addtitle><description>We examined the association between inflammation and progression of arterial stiffness in a population of youth with type 1 diabetes (T1D).
A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammation (CRP, IL-6, fibrinogen, leptin, and adiponectin) and measures of pulse wave velocity (PWV) of the arm (PWV-R), trunk (PWV-T), and lower extremity (PWV-LE) were measured at baseline. Measures of PWV were repeated approximately five years later.
PWV-R (0.50 m/s), PWV-T (0.65 m/s), and PWV-LE (1.0 m/s) significantly increased over the follow-up (p < 0.001 for each). A significant interaction was found between waist circumference and fibrinogen (p = 0.036) on the progression of PWV-T, suggesting that fibrinogen is more strongly associated with PWV progression in lean participants.
Improved understanding of adiposity, inflammation, and functional changes in the vascular system in patients with T1D is crucial.</description><subject>Age</subject><subject>Arterial stiffness</subject><subject>Atherosclerosis</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Fibrinogen</subject><subject>Inflammation</subject><subject>Insulin resistance</subject><subject>Laboratories</subject><subject>Lipoproteins</subject><subject>Metabolism</subject><subject>Population</subject><subject>Proteins</subject><subject>Pulse wave analysis</subject><subject>Teenagers</subject><subject>Triglycerides</subject><subject>Type 1 diabetes mellitus</subject><subject>Waist circumference</subject><subject>Young adults</subject><issn>1056-8727</issn><issn>1873-460X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkVFrFDEQxxdRbK1-hRLwxQf3TLK72ZwPYjmrLRQEW8W3MJud9LLsJmuSq71v3xzXFvVFGMjA_zeTmfkXxTGjC0aZeDcsht6C9tO84JTJBc1B6yfFIZNtVdaC_nyac9qIUra8PShexDhQSkXTsOfFQUU5XVK2PCxuz50ZYZogWe_eEujt7KNN25y6nszBXweMMWvEGwIhYbAwkpisMS4LxLpc40eMGl2K5LdNa5K2MxJG8nwdJozvydUayeXpybfVGVn9-EQu06bfviyeGRgjvrp_j4rvn0-vVmflxdcv56uTi1LXy2UqjRFSgKxMLSWXHCteawOGykYLaEGzDg0AoBSMN9D3HDrQ0PW6AZZxqI6KD_u-86absN-NGWBUc7AThK3yYNXfirNrde1vlGBtnQ-YG7y5bxD8rw3GpCabtx1HcOg3UXFGK9E2FWMZff0POvhNcHm9TDFB881bnimxp3TwMQY0j8MwqnbmqkE9mKt25iqag9a58PjPVR7LHtzMwMc9gPmgNxaDitqi09jbgDqp3tv__XEH8_C77g</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Alman, Amy C.</creator><creator>Talton, Jennifer W.</creator><creator>Wadwa, R. Paul</creator><creator>Urbina, Elaine M.</creator><creator>Dolan, Lawrence M.</creator><creator>Hamman, Richard F.</creator><creator>D'Agostino, Ralph B.</creator><creator>Marcovina, Santica M.</creator><creator>Dabelea, Dana M.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3609-2595</orcidid></search><sort><creationdate>20181101</creationdate><title>Inflammation, adiposity, and progression of arterial stiffness in adolescents with type 1 diabetes: The SEARCH CVD Study</title><author>Alman, Amy C. ; Talton, Jennifer W. ; Wadwa, R. Paul ; Urbina, Elaine M. ; Dolan, Lawrence M. ; Hamman, Richard F. ; D'Agostino, Ralph B. ; Marcovina, Santica M. ; Dabelea, Dana M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-ff686a83f488282e324cfaf085c6a7ac1befaaae86125add2abacabdc5a182ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Arterial stiffness</topic><topic>Atherosclerosis</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Fibrinogen</topic><topic>Inflammation</topic><topic>Insulin resistance</topic><topic>Laboratories</topic><topic>Lipoproteins</topic><topic>Metabolism</topic><topic>Population</topic><topic>Proteins</topic><topic>Pulse wave analysis</topic><topic>Teenagers</topic><topic>Triglycerides</topic><topic>Type 1 diabetes mellitus</topic><topic>Waist circumference</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alman, Amy C.</creatorcontrib><creatorcontrib>Talton, Jennifer W.</creatorcontrib><creatorcontrib>Wadwa, R. Paul</creatorcontrib><creatorcontrib>Urbina, Elaine M.</creatorcontrib><creatorcontrib>Dolan, Lawrence M.</creatorcontrib><creatorcontrib>Hamman, Richard F.</creatorcontrib><creatorcontrib>D'Agostino, Ralph B.</creatorcontrib><creatorcontrib>Marcovina, Santica M.</creatorcontrib><creatorcontrib>Dabelea, Dana M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of diabetes and its complications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alman, Amy C.</au><au>Talton, Jennifer W.</au><au>Wadwa, R. Paul</au><au>Urbina, Elaine M.</au><au>Dolan, Lawrence M.</au><au>Hamman, Richard F.</au><au>D'Agostino, Ralph B.</au><au>Marcovina, Santica M.</au><au>Dabelea, Dana M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammation, adiposity, and progression of arterial stiffness in adolescents with type 1 diabetes: The SEARCH CVD Study</atitle><jtitle>Journal of diabetes and its complications</jtitle><addtitle>J Diabetes Complications</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>32</volume><issue>11</issue><spage>995</spage><epage>999</epage><pages>995-999</pages><issn>1056-8727</issn><eissn>1873-460X</eissn><abstract>We examined the association between inflammation and progression of arterial stiffness in a population of youth with type 1 diabetes (T1D).
A total of 287 youth with T1D (median age 13 years) from SEARCH CVD, an ancillary study to the SEARCH for Diabetes in Youth, were included. Markers of inflammation (CRP, IL-6, fibrinogen, leptin, and adiponectin) and measures of pulse wave velocity (PWV) of the arm (PWV-R), trunk (PWV-T), and lower extremity (PWV-LE) were measured at baseline. Measures of PWV were repeated approximately five years later.
PWV-R (0.50 m/s), PWV-T (0.65 m/s), and PWV-LE (1.0 m/s) significantly increased over the follow-up (p < 0.001 for each). A significant interaction was found between waist circumference and fibrinogen (p = 0.036) on the progression of PWV-T, suggesting that fibrinogen is more strongly associated with PWV progression in lean participants.
Improved understanding of adiposity, inflammation, and functional changes in the vascular system in patients with T1D is crucial.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30209019</pmid><doi>10.1016/j.jdiacomp.2018.08.004</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-3609-2595</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1056-8727 |
| ispartof | Journal of diabetes and its complications, 2018-11, Vol.32 (11), p.995-999 |
| issn | 1056-8727 1873-460X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6174105 |
| source | Elsevier ScienceDirect Journals |
| subjects | Age Arterial stiffness Atherosclerosis Cardiovascular disease Cholesterol Cytokines Diabetes Fibrinogen Inflammation Insulin resistance Laboratories Lipoproteins Metabolism Population Proteins Pulse wave analysis Teenagers Triglycerides Type 1 diabetes mellitus Waist circumference Young adults |
| title | Inflammation, adiposity, and progression of arterial stiffness in adolescents with type 1 diabetes: The SEARCH CVD Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T10%3A49%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inflammation,%20adiposity,%20and%20progression%20of%20arterial%20stiffness%20in%20adolescents%20with%20type%201%20diabetes:%20The%20SEARCH%20CVD%20Study&rft.jtitle=Journal%20of%20diabetes%20and%20its%20complications&rft.au=Alman,%20Amy%20C.&rft.date=2018-11-01&rft.volume=32&rft.issue=11&rft.spage=995&rft.epage=999&rft.pages=995-999&rft.issn=1056-8727&rft.eissn=1873-460X&rft_id=info:doi/10.1016/j.jdiacomp.2018.08.004&rft_dat=%3Cproquest_pubme%3E2116009072%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2116009072&rft_id=info:pmid/30209019&rft_els_id=S1056872717305470&rfr_iscdi=true |