Pelvic radiotherapy for cervical cancer affects importantly the reproducibility of cytological alterations evaluation
to evaluate the intraobserver and interobserver reproducibility of cervical cytopathology according to previous knowledge of whether patients received radiotherapy (RT) treatment or not. The study analyzed a sample of 95 cervix cytological slides; 24 with cytological abnormalities (CA) and presence...
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| Veröffentlicht in: | BMC clinical pathology 2018-10, Vol.18 (1), p.11-11, Article 11 |
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| creator | Lucena, Fernanda A Costa, Ricardo F A Stein, Maira D Andrade, Carlos E M C Cintra, Geórgia F Vieira, Marcelo A Dufloth, Rozany M Fregnani, José Humberto T G Dos Reis, Ricardo |
| description | to evaluate the intraobserver and interobserver reproducibility of cervical cytopathology according to previous knowledge of whether patients received radiotherapy (RT) treatment or not.
The study analyzed a sample of 95 cervix cytological slides; 24 with cytological abnormalities (CA) and presence of RT; 21 without CA and presence of RT; 25 without CA and without previous RT; 25 with CA and without previous RT. Two cytopathology (CP) evaluations of the slides were carried out. For the first CP re-evaluation, the cytotechnologist was blinded for the information of previous RT. For the second CP re-evaluation, the cytotechnologist was informed about previous RT. The results were analyzed through inter and intraobserver agreement using the unweighted and weighted kappa.
Post radiotherapy effects were identified in 44.4% of cases that undergone previous pelvic RT. The agreement for RT status was 66.32% (unweighted K = 0.31, 95%CI: 0.13; 0.49, moderate agreement). The intraobserver agreement, regarding the cytological diagnoses, regardless of radiotherapy status, was 80.32% (weighted K = 0.52, 95%CI: 0.34; 0.68). In no RT group, the intraobserver agreement was 70% (weighted K = 0.47, 95%CI: 0.27;0.65) and in patients that received RT, the intraobserver agreement was 84.09% (unweighted K = 0.37, 95%CI: 0.01;0.74). The interobserver agreement between cytopathology result (abnormal or normal) in the group with RT, considering normal and abnormal CP diagnosis was 14.0% and 12.5%, respectively. There was no association between the cytological alterations and the median time between the end of RT and the cytological diagnosis.
This study showed that RT has an important impact in CP diagnosis because the agreement, also in interobserver and intraobserver analysis, had high discrepancy in patients that received RT. Also, demonstrated that it is difficult to recognize the presence of RT in cytological slides when this information is not provided. |
| doi_str_mv | 10.1186/s12907-018-0078-z |
| format | Article |
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The study analyzed a sample of 95 cervix cytological slides; 24 with cytological abnormalities (CA) and presence of RT; 21 without CA and presence of RT; 25 without CA and without previous RT; 25 with CA and without previous RT. Two cytopathology (CP) evaluations of the slides were carried out. For the first CP re-evaluation, the cytotechnologist was blinded for the information of previous RT. For the second CP re-evaluation, the cytotechnologist was informed about previous RT. The results were analyzed through inter and intraobserver agreement using the unweighted and weighted kappa.
Post radiotherapy effects were identified in 44.4% of cases that undergone previous pelvic RT. The agreement for RT status was 66.32% (unweighted K = 0.31, 95%CI: 0.13; 0.49, moderate agreement). The intraobserver agreement, regarding the cytological diagnoses, regardless of radiotherapy status, was 80.32% (weighted K = 0.52, 95%CI: 0.34; 0.68). In no RT group, the intraobserver agreement was 70% (weighted K = 0.47, 95%CI: 0.27;0.65) and in patients that received RT, the intraobserver agreement was 84.09% (unweighted K = 0.37, 95%CI: 0.01;0.74). The interobserver agreement between cytopathology result (abnormal or normal) in the group with RT, considering normal and abnormal CP diagnosis was 14.0% and 12.5%, respectively. There was no association between the cytological alterations and the median time between the end of RT and the cytological diagnosis.
This study showed that RT has an important impact in CP diagnosis because the agreement, also in interobserver and intraobserver analysis, had high discrepancy in patients that received RT. Also, demonstrated that it is difficult to recognize the presence of RT in cytological slides when this information is not provided.</description><identifier>ISSN: 1472-6890</identifier><identifier>EISSN: 1472-6890</identifier><identifier>DOI: 10.1186/s12907-018-0078-z</identifier><identifier>PMID: 30323716</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Accuracy ; Analysis ; Cancer therapies ; Care and treatment ; Cellular biology ; Cervical cancer ; Cytopathology ; Diagnosis ; Evaluation ; Human papillomavirus ; Patients ; Radiation therapy ; Radiotherapy ; Reproducibility ; Rodeos</subject><ispartof>BMC clinical pathology, 2018-10, Vol.18 (1), p.11-11, Article 11</ispartof><rights>COPYRIGHT 2018 BioMed Central Ltd.</rights><rights>Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s). 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-1fe49fe9e2621c45c881c3fcd3f754c48ffb21076c2bd07e7d1dbce8cf05f5e63</citedby><cites>FETCH-LOGICAL-c494t-1fe49fe9e2621c45c881c3fcd3f754c48ffb21076c2bd07e7d1dbce8cf05f5e63</cites><orcidid>0000-0001-5016-2137</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173841/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173841/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30323716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lucena, Fernanda A</creatorcontrib><creatorcontrib>Costa, Ricardo F A</creatorcontrib><creatorcontrib>Stein, Maira D</creatorcontrib><creatorcontrib>Andrade, Carlos E M C</creatorcontrib><creatorcontrib>Cintra, Geórgia F</creatorcontrib><creatorcontrib>Vieira, Marcelo A</creatorcontrib><creatorcontrib>Dufloth, Rozany M</creatorcontrib><creatorcontrib>Fregnani, José Humberto T G</creatorcontrib><creatorcontrib>Dos Reis, Ricardo</creatorcontrib><title>Pelvic radiotherapy for cervical cancer affects importantly the reproducibility of cytological alterations evaluation</title><title>BMC clinical pathology</title><addtitle>BMC Clin Pathol</addtitle><description>to evaluate the intraobserver and interobserver reproducibility of cervical cytopathology according to previous knowledge of whether patients received radiotherapy (RT) treatment or not.
The study analyzed a sample of 95 cervix cytological slides; 24 with cytological abnormalities (CA) and presence of RT; 21 without CA and presence of RT; 25 without CA and without previous RT; 25 with CA and without previous RT. Two cytopathology (CP) evaluations of the slides were carried out. For the first CP re-evaluation, the cytotechnologist was blinded for the information of previous RT. For the second CP re-evaluation, the cytotechnologist was informed about previous RT. The results were analyzed through inter and intraobserver agreement using the unweighted and weighted kappa.
Post radiotherapy effects were identified in 44.4% of cases that undergone previous pelvic RT. The agreement for RT status was 66.32% (unweighted K = 0.31, 95%CI: 0.13; 0.49, moderate agreement). The intraobserver agreement, regarding the cytological diagnoses, regardless of radiotherapy status, was 80.32% (weighted K = 0.52, 95%CI: 0.34; 0.68). In no RT group, the intraobserver agreement was 70% (weighted K = 0.47, 95%CI: 0.27;0.65) and in patients that received RT, the intraobserver agreement was 84.09% (unweighted K = 0.37, 95%CI: 0.01;0.74). The interobserver agreement between cytopathology result (abnormal or normal) in the group with RT, considering normal and abnormal CP diagnosis was 14.0% and 12.5%, respectively. There was no association between the cytological alterations and the median time between the end of RT and the cytological diagnosis.
This study showed that RT has an important impact in CP diagnosis because the agreement, also in interobserver and intraobserver analysis, had high discrepancy in patients that received RT. Also, demonstrated that it is difficult to recognize the presence of RT in cytological slides when this information is not provided.</description><subject>Accuracy</subject><subject>Analysis</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Cellular biology</subject><subject>Cervical cancer</subject><subject>Cytopathology</subject><subject>Diagnosis</subject><subject>Evaluation</subject><subject>Human papillomavirus</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Radiotherapy</subject><subject>Reproducibility</subject><subject>Rodeos</subject><issn>1472-6890</issn><issn>1472-6890</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkktv1TAQhSMEog_4AWyQJTZsUvxIYmeDVFVQkCrBAtaWMxnfunLiYDtXuv31-PaW0iLkhUfj75zRWKeq3jB6xpjqPiTGeyprylRNqVT17bPqmDWS153q6fNH9VF1ktINpUwqxl9WR4IKLiTrjqv1O_qtAxLN6EK-xmiWHbEhEsBY-sYTMHOpibEWISfipiXEbObsd6TwJOISw7iCG5x3eUeCJbDLwYfNndr4XDyzC3MiuDV-vatfVS-s8Qlf39-n1c_Pn35cfKmvvl1-vTi_qqHpm1wzi01vsUfecQZNC0oxEBZGYWXbQKOsHTijsgM-jFSiHNk4ACqwtLUtduK0-njwXdZhwhFwztF4vUQ3mbjTwTj99GV213oTtrpjUqiGFYP39wYx_FoxZT25BOi9mTGsSXPGqWx408uCvvsHvQlrnMt6e4qLVvWS_6U2xqN2sw1lLuxN9XnbSsZbqkShzv5DlTPi5CDMaF3pPxGwgwBiSCmifdiRUb3Pij5kRZes6H1W9G3RvH38OQ-KP-EQvwHhhr2c</recordid><startdate>20181005</startdate><enddate>20181005</enddate><creator>Lucena, Fernanda A</creator><creator>Costa, Ricardo F A</creator><creator>Stein, Maira D</creator><creator>Andrade, Carlos E M C</creator><creator>Cintra, Geórgia F</creator><creator>Vieira, Marcelo A</creator><creator>Dufloth, Rozany M</creator><creator>Fregnani, José Humberto T G</creator><creator>Dos Reis, Ricardo</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5016-2137</orcidid></search><sort><creationdate>20181005</creationdate><title>Pelvic radiotherapy for cervical cancer affects importantly the reproducibility of cytological alterations evaluation</title><author>Lucena, Fernanda A ; Costa, Ricardo F A ; Stein, Maira D ; Andrade, Carlos E M C ; Cintra, Geórgia F ; Vieira, Marcelo A ; Dufloth, Rozany M ; Fregnani, José Humberto T G ; Dos Reis, Ricardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-1fe49fe9e2621c45c881c3fcd3f754c48ffb21076c2bd07e7d1dbce8cf05f5e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Accuracy</topic><topic>Analysis</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Cellular biology</topic><topic>Cervical cancer</topic><topic>Cytopathology</topic><topic>Diagnosis</topic><topic>Evaluation</topic><topic>Human papillomavirus</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Radiotherapy</topic><topic>Reproducibility</topic><topic>Rodeos</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lucena, Fernanda A</creatorcontrib><creatorcontrib>Costa, Ricardo F A</creatorcontrib><creatorcontrib>Stein, Maira D</creatorcontrib><creatorcontrib>Andrade, Carlos E M C</creatorcontrib><creatorcontrib>Cintra, Geórgia F</creatorcontrib><creatorcontrib>Vieira, Marcelo A</creatorcontrib><creatorcontrib>Dufloth, Rozany M</creatorcontrib><creatorcontrib>Fregnani, José Humberto T G</creatorcontrib><creatorcontrib>Dos Reis, Ricardo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lucena, Fernanda A</au><au>Costa, Ricardo F A</au><au>Stein, Maira D</au><au>Andrade, Carlos E M C</au><au>Cintra, Geórgia F</au><au>Vieira, Marcelo A</au><au>Dufloth, Rozany M</au><au>Fregnani, José Humberto T G</au><au>Dos Reis, Ricardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pelvic radiotherapy for cervical cancer affects importantly the reproducibility of cytological alterations evaluation</atitle><jtitle>BMC clinical pathology</jtitle><addtitle>BMC Clin Pathol</addtitle><date>2018-10-05</date><risdate>2018</risdate><volume>18</volume><issue>1</issue><spage>11</spage><epage>11</epage><pages>11-11</pages><artnum>11</artnum><issn>1472-6890</issn><eissn>1472-6890</eissn><abstract>to evaluate the intraobserver and interobserver reproducibility of cervical cytopathology according to previous knowledge of whether patients received radiotherapy (RT) treatment or not.
The study analyzed a sample of 95 cervix cytological slides; 24 with cytological abnormalities (CA) and presence of RT; 21 without CA and presence of RT; 25 without CA and without previous RT; 25 with CA and without previous RT. Two cytopathology (CP) evaluations of the slides were carried out. For the first CP re-evaluation, the cytotechnologist was blinded for the information of previous RT. For the second CP re-evaluation, the cytotechnologist was informed about previous RT. The results were analyzed through inter and intraobserver agreement using the unweighted and weighted kappa.
Post radiotherapy effects were identified in 44.4% of cases that undergone previous pelvic RT. The agreement for RT status was 66.32% (unweighted K = 0.31, 95%CI: 0.13; 0.49, moderate agreement). The intraobserver agreement, regarding the cytological diagnoses, regardless of radiotherapy status, was 80.32% (weighted K = 0.52, 95%CI: 0.34; 0.68). In no RT group, the intraobserver agreement was 70% (weighted K = 0.47, 95%CI: 0.27;0.65) and in patients that received RT, the intraobserver agreement was 84.09% (unweighted K = 0.37, 95%CI: 0.01;0.74). The interobserver agreement between cytopathology result (abnormal or normal) in the group with RT, considering normal and abnormal CP diagnosis was 14.0% and 12.5%, respectively. There was no association between the cytological alterations and the median time between the end of RT and the cytological diagnosis.
This study showed that RT has an important impact in CP diagnosis because the agreement, also in interobserver and intraobserver analysis, had high discrepancy in patients that received RT. Also, demonstrated that it is difficult to recognize the presence of RT in cytological slides when this information is not provided.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>30323716</pmid><doi>10.1186/s12907-018-0078-z</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-5016-2137</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; Springer Nature OA Free Journals; Access via BioMed Central; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Accuracy Analysis Cancer therapies Care and treatment Cellular biology Cervical cancer Cytopathology Diagnosis Evaluation Human papillomavirus Patients Radiation therapy Radiotherapy Reproducibility Rodeos |
| title | Pelvic radiotherapy for cervical cancer affects importantly the reproducibility of cytological alterations evaluation |
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