The macula densa prorenin receptor is essential in renin release and blood pressure control

The prorenin receptor (PRR) was originally proposed to be a member of the renin-angiotensin system (RAS); however, recent work questioned their association. The present paper describes a functional link between the PRR and RAS in the renal juxtaglomerular apparatus (JGA), a classic anatomical site o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Renal physiology 2018-09, Vol.315 (3), p.F521-F534
Hauptverfasser:	Riquier-Brison, Anne D M, Sipos, Arnold, Prókai, Ágnes, Vargas, Sarah L, Toma, Lldikó, Meer, Elliott J, Villanueva, Karie G, Chen, Jennifer C M, Gyarmati, Georgina, Yih, Christopher, Tang, Elaine, Nadim, Bahram, Pendekanti, Sujith, Garrelds, Ingrid M, Nguyen, Genevieve, Danser, A H Jan, Peti-Peterdi, János
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Biosensing Techniques Blood pressure Blood Pressure - drug effects Captopril - pharmacology Cell activation Cell membranes Cellular biology Clonal deletion Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Diet, Sodium-Restricted Dinoprostone - metabolism Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Gene deletion Gene expression HEK293 Cells Humans Immunohistochemistry Juxtaglomerular Apparatus - drug effects Juxtaglomerular Apparatus - enzymology Kidney diseases Male MAP kinase Mice, Inbred C57BL Mice, Knockout Nitric oxide Nitric-oxide synthase Nutrient deficiency Prostaglandin E2 Prostaglandin-E Synthases - metabolism Proton-Translocating ATPases - deficiency Proton-Translocating ATPases - genetics Proton-Translocating ATPases - metabolism Rats, Sprague-Dawley Receptors, Cell Surface - deficiency Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Recombination Renin Renin - metabolism Renin-Angiotensin System - drug effects Secretory Pathway Signal Transduction Vacuolar Proton-Translocating ATPases - genetics Vacuolar Proton-Translocating ATPases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!