DNA damage‐induced replication stress results in PA200‐proteasome‐mediated degradation of acetylated histones

Histone acetylation influences protein interactions and chromatin accessibility and plays an important role in the regulation of transcription, replication, and DNA repair. Conversely, DNA damage affects these crucial cellular processes and induces changes in histone acetylation. However, a comprehe...

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Veröffentlicht in:	EMBO reports 2018-10, Vol.19 (10), p.n/a
Hauptverfasser:	Mandemaker, Imke K, Geijer, Marit E, Kik, Iris, Bezstarosti, Karel, Rijkers, Erikjan, Raams, Anja, Janssens, Roel C, Lans, Hannes, Hoeijmakers, Jan HJ, Demmers, Jeroen AA, Vermeulen, Wim, Marteijn, Jurgen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Amino Acid Sequence - genetics Chromatin Chromatin - genetics Damage Degradation Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA Damage - genetics DNA repair DNA Repair - genetics DNA Replication - genetics EMBO09 EMBO13 Gene regulation histone Histones Histones - genetics Humans Mass spectrometry Mass spectroscopy Nuclear Proteins - genetics PA200‐proteasome Peptides Proteasome activator Proteasome Endopeptidase Complex - genetics Protein interaction Proteins Proteolysis Replication replication stress Stress Stresses Transcription Ubiquitin Ubiquitination - genetics
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