Long noncoding RNA n339260 promotes vasculogenic mimicry and cancer stem cell development in hepatocellular carcinoma

Vasculogenic mimicry (VM) refers to the unique capability of aggressive tumor cells to mimic the pattern of embryonic vasculogenic networks. Cancer stem cells (CSC) represent a subpopulation of tumor cells endowed with the capacity for self‐renewal and multilineage differentiation. Previous studies...

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Veröffentlicht in:	Cancer science 2018-10, Vol.109 (10), p.3197-3208
Hauptverfasser:	Zhao, Xiulan, Sun, Baocun, Liu, Tieju, Shao, Bing, Sun, Ran, Zhu, Dongwang, Zhang, Yanhui, Gu, Qiang, Dong, Xueyi, Liu, Fang, Zhao, Nan, Zhang, Danfang, Li, Yanlei, Meng, Jie, Gong, Wenchen, Zheng, Yanjun, Zheng, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal models Animals Breast cancer Cadherins cancer stem cell Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cell adhesion & migration Cell culture Cell Differentiation - genetics Cell self-renewal Cloning Embryo cells Epithelial-Mesenchymal Transition - genetics Female Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genotype & phenotype Growth factors Hep G2 Cells Hepatectomy Hepatocellular carcinoma Humans Hybridization Liver - pathology Liver - surgery Liver cancer Liver Neoplasms - blood supply Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - pathology lncRNA n339260 Medical prognosis Metastases metastasis Mice Mice, Inbred BALB C Mice, Nude Microscopy Mimicry Neoplastic Stem Cells - pathology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - mortality Neovascularization, Pathologic - pathology Original Phenotypes Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Small Interfering - metabolism Spheroids, Cellular Stem cell transplantation Stem cells Therapeutic applications Tumor cells Tumorigenesis vasculogenic mimicry Xenograft Model Antitumor Assays
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