Multidrug‐resistant transporter expression does not always result in drug resistance
Chemotherapeutics used by Sasaki et al are not all standard of care for PDAC, precluding relevance for clinical practice. [...]studies should evaluate the correlation of ABCG2 expression with chemoresistance in a larger panel of cytotoxic agents used against PDAC, as well as report data on well‐know...
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| Veröffentlicht in: | Cancer science 2018-10, Vol.109 (10), p.3360-3362 |
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| container_title | Cancer science |
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| creator | Le Large, Tessa Ya Sung El Hassouni, Btissame Kazemier, Geert Piersma, Sander R. Laarhoven, Hanneke W. M. Bijlsma, Maarten F. Jimenez, Cornelia R. Giovannetti, Elisa |
| description | Chemotherapeutics used by Sasaki et al are not all standard of care for PDAC, precluding relevance for clinical practice. [...]studies should evaluate the correlation of ABCG2 expression with chemoresistance in a larger panel of cytotoxic agents used against PDAC, as well as report data on well‐known gemcitabine determinants, such as ENT1. [...]verapamil was previously found to be inactive against ABCG2. [...]chemoresistance contributes to poor prognosis in PDAC patients, and understanding the mechanisms that underlie this phenomenon will pave the way for improved therapy response. |
| doi_str_mv | 10.1111/cas.13756 |
| format | Article |
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| ispartof | Cancer science, 2018-10, Vol.109 (10), p.3360-3362 |
| issn | 1347-9032 1349-7006 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; PubMed Central |
| subjects | ABC transporters Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Cancer Cell Line, Tumor Chemoresistance Cytotoxic agents Cytotoxicity Drug dosages Drug resistance Drug Resistance, Multiple - drug effects Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Gemcitabine Gene expression Humans Letter to the Editor Medical prognosis Medical research Multidrug resistance Phosphorylation Stem cells Up-Regulation - genetics Verapamil |
| title | Multidrug‐resistant transporter expression does not always result in drug resistance |
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