Inhibition of tumor formation and metastasis by a monoclonal antibody against lymphatic vessel endothelial hyaluronan receptor 1

Although cancer metastasis is associated with poor prognosis, the mechanisms of this event, especially via lymphatic vessels, remain unclear. Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE‐1) is expressed on lymphatic vessel endothelium and is considered to be a specific marker of lymphati...

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Veröffentlicht in:	Cancer science 2018-10, Vol.109 (10), p.3171-3182
Hauptverfasser:	Hara, Yuta, Torii, Ryota, Ueda, Shiho, Kurimoto, Erina, Ueda, Eri, Okura, Hiroshi, Tatano, Yutaka, Yagi, Hideki, Ohno, Yoshiya, Tanaka, Toshiyuki, Masuko, Kazue, Masuko, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Breast cancer Cancer Cancer therapies Cell adhesion & migration Cell fusion Cell Line, Tumor Cell migration Cell Movement - drug effects Endothelial cells Endothelial Cells - pathology Endothelium Enzymes Epitopes Experiments Female Gene expression Glycoproteins - antagonists & inhibitors Glycoproteins - metabolism Green fluorescent protein HEK293 Cells Hepatoma Humans Hyaluronan Receptors - antagonists & inhibitors Hyaluronan Receptors - metabolism Hyaluronic acid Hybridomas Immunization Kinases Laboratory animals Lymph nodes Lymph Nodes - pathology lymphangiogenesis Lymphatic Metastasis Lymphatic system lymphatic vessel endothelial hyaluronan receptor 1 Male Membrane Transport Proteins Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Mice, SCID Monoclonal antibodies monoclonal antibody Multiple myeloma Myeloma Neoplasms - drug therapy Neoplasms - pathology Original primary tumor Proteins Rats Spleen Studies Tumors Vascular endothelial growth factor Wound healing Xenograft Model Antitumor Assays Xenografts
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