Nucleus basalis of Meynert degeneration precedes and predicts cognitive impairment in Parkinson's disease
There are currently no reliable predictors of cognitive impairment in Parkinson's disease. Using both cross-sectional and longitudinal comparisons, Schulz et al. report that grey matter volume loss and increased mean diffusivity in the nucleus basalis of Meynert is predictive of cognitive impai...
Gespeichert in:
| Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 2018-05, Vol.141 (5), p.1501-1516 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1516 |
|---|---|
| container_issue | 5 |
| container_start_page | 1501 |
| container_title | Brain (London, England : 1878) |
| container_volume | 141 |
| creator | Schulz, Jonathan Pagano, Gennaro Fernández Bonfante, Juan Alberto Wilson, Heather Politis, Marios |
| description | There are currently no reliable predictors of cognitive impairment in Parkinson's disease. Using both cross-sectional and longitudinal comparisons, Schulz et al. report that grey matter volume loss and increased mean diffusivity in the nucleus basalis of Meynert is predictive of cognitive impairment in Parkinson's disease.
Abstract
Currently, no reliable predictors of cognitive impairment in Parkinson's disease exist. We hypothesized that microstructural changes at grey matter T1-weighted MRI and diffusion tensor imaging in the cholinergic system nuclei and associated limbic pathways underlie cognitive impairment in Parkinson's disease. We performed a cross-sectional comparison between patients with Parkinson's disease with and without cognitive impairment. We also performed a longitudinal 36-month follow-up study of cognitively intact Parkinson's disease patients, comparing patients who remained cognitively intact to those who developed cognitive impairment. Patients with Parkinson's disease with cognitive impairment showed lower grey matter volume and increased mean diffusivity in the nucleus basalis of Meynert, compared to patients with Parkinson's disease without cognitive impairment. These results were confirmed both with region of interest and voxel-based analyses, and after partial volume correction. Lower grey matter volume and increased mean diffusivity in the nucleus basalis of Meynert was predictive for developing cognitive impairment in cognitively intact patients with Parkinson's disease, independent of other clinical and non-clinical markers of the disease. Structural and microstructural alterations in entorhinal cortex, amygdala, hippocampus, insula, and thalamus were not predictive for developing cognitive impairment in Parkinson's disease. Our findings provide evidence that degeneration of the nucleus basalis of Meynert precedes and predicts the onset of cognitive impairment, and might be used in a clinical setting as a reliable biomarker to stratify patients at higher risk of cognitive decline. |
| doi_str_mv | 10.1093/brain/awy072 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6171218</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/brain/awy072</oup_id><sourcerecordid>2032437709</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-c06b02a288b4db4a9f9e50c74c7f0159f1bee2637ff4b4fab64017f087fddc8c3</originalsourceid><addsrcrecordid>eNp9kctv1DAQxi0EotuFG2fkWzk0dOx44-SChKq-pPI4tGfLj_FiSOxgJ0X735N2SwUXTjOj-embx0fIGwbvGXT1ick6xBP9aweSPyMrJhqoONs0z8kKAJqq7TZwQA5L-Q7ARM2bl-SAdxKYbOWKhM-z7XEu1Oii-1Bo8vQT7iLmiTrc4pLoKaRIx4wWHRaqo7svXLBToTZtY5jCHdIwjDrkAeNEQ6Rfdf4RYknxqFAXCuqCr8gLr_uCrx_jmtyen92cXlbXXy6uTj9eV1a0fKosNAa45m1rhDNCd77DDVgprPTANp1nBpE3tfReGOG1acRyiodWeudsa-s1-bDXHWczoLPLRln3asxh0Hmnkg7q304M39Q23amGScZZuwi8exTI6eeMZVJDKBb7XkdMc1Ecai5qKZfnr8nxHrU5lZLRP41hoO7dUQ_uqL07C_7279We4D92LMDRHkjz-H-p3yS-njE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2032437709</pqid></control><display><type>article</type><title>Nucleus basalis of Meynert degeneration precedes and predicts cognitive impairment in Parkinson's disease</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Schulz, Jonathan ; Pagano, Gennaro ; Fernández Bonfante, Juan Alberto ; Wilson, Heather ; Politis, Marios</creator><creatorcontrib>Schulz, Jonathan ; Pagano, Gennaro ; Fernández Bonfante, Juan Alberto ; Wilson, Heather ; Politis, Marios</creatorcontrib><description>There are currently no reliable predictors of cognitive impairment in Parkinson's disease. Using both cross-sectional and longitudinal comparisons, Schulz et al. report that grey matter volume loss and increased mean diffusivity in the nucleus basalis of Meynert is predictive of cognitive impairment in Parkinson's disease.
Abstract
Currently, no reliable predictors of cognitive impairment in Parkinson's disease exist. We hypothesized that microstructural changes at grey matter T1-weighted MRI and diffusion tensor imaging in the cholinergic system nuclei and associated limbic pathways underlie cognitive impairment in Parkinson's disease. We performed a cross-sectional comparison between patients with Parkinson's disease with and without cognitive impairment. We also performed a longitudinal 36-month follow-up study of cognitively intact Parkinson's disease patients, comparing patients who remained cognitively intact to those who developed cognitive impairment. Patients with Parkinson's disease with cognitive impairment showed lower grey matter volume and increased mean diffusivity in the nucleus basalis of Meynert, compared to patients with Parkinson's disease without cognitive impairment. These results were confirmed both with region of interest and voxel-based analyses, and after partial volume correction. Lower grey matter volume and increased mean diffusivity in the nucleus basalis of Meynert was predictive for developing cognitive impairment in cognitively intact patients with Parkinson's disease, independent of other clinical and non-clinical markers of the disease. Structural and microstructural alterations in entorhinal cortex, amygdala, hippocampus, insula, and thalamus were not predictive for developing cognitive impairment in Parkinson's disease. Our findings provide evidence that degeneration of the nucleus basalis of Meynert precedes and predicts the onset of cognitive impairment, and might be used in a clinical setting as a reliable biomarker to stratify patients at higher risk of cognitive decline.</description><identifier>ISSN: 0006-8950</identifier><identifier>ISSN: 1460-2156</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/awy072</identifier><identifier>PMID: 29701787</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Aged ; Basal Nucleus of Meynert - diagnostic imaging ; Cerebral Cortex - diagnostic imaging ; Cognitive Dysfunction - diagnostic imaging ; Cognitive Dysfunction - etiology ; Diffusion Tensor Imaging ; Female ; Gray Matter - diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; Nerve Degeneration - diagnostic imaging ; Nerve Degeneration - etiology ; Neuropsychological Tests ; Original ; Parkinson Disease - complications</subject><ispartof>Brain (London, England : 1878), 2018-05, Vol.141 (5), p.1501-1516</ispartof><rights>The Author(s) (2018). Published by Oxford University Press on behalf of the Guarantors of Brain. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-c06b02a288b4db4a9f9e50c74c7f0159f1bee2637ff4b4fab64017f087fddc8c3</citedby><cites>FETCH-LOGICAL-c482t-c06b02a288b4db4a9f9e50c74c7f0159f1bee2637ff4b4fab64017f087fddc8c3</cites><orcidid>0000-0001-8530-7113 ; 0000-0002-6247-8988</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,1579,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29701787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schulz, Jonathan</creatorcontrib><creatorcontrib>Pagano, Gennaro</creatorcontrib><creatorcontrib>Fernández Bonfante, Juan Alberto</creatorcontrib><creatorcontrib>Wilson, Heather</creatorcontrib><creatorcontrib>Politis, Marios</creatorcontrib><title>Nucleus basalis of Meynert degeneration precedes and predicts cognitive impairment in Parkinson's disease</title><title>Brain (London, England : 1878)</title><addtitle>Brain</addtitle><description>There are currently no reliable predictors of cognitive impairment in Parkinson's disease. Using both cross-sectional and longitudinal comparisons, Schulz et al. report that grey matter volume loss and increased mean diffusivity in the nucleus basalis of Meynert is predictive of cognitive impairment in Parkinson's disease.
Abstract
Currently, no reliable predictors of cognitive impairment in Parkinson's disease exist. We hypothesized that microstructural changes at grey matter T1-weighted MRI and diffusion tensor imaging in the cholinergic system nuclei and associated limbic pathways underlie cognitive impairment in Parkinson's disease. We performed a cross-sectional comparison between patients with Parkinson's disease with and without cognitive impairment. We also performed a longitudinal 36-month follow-up study of cognitively intact Parkinson's disease patients, comparing patients who remained cognitively intact to those who developed cognitive impairment. Patients with Parkinson's disease with cognitive impairment showed lower grey matter volume and increased mean diffusivity in the nucleus basalis of Meynert, compared to patients with Parkinson's disease without cognitive impairment. These results were confirmed both with region of interest and voxel-based analyses, and after partial volume correction. Lower grey matter volume and increased mean diffusivity in the nucleus basalis of Meynert was predictive for developing cognitive impairment in cognitively intact patients with Parkinson's disease, independent of other clinical and non-clinical markers of the disease. Structural and microstructural alterations in entorhinal cortex, amygdala, hippocampus, insula, and thalamus were not predictive for developing cognitive impairment in Parkinson's disease. Our findings provide evidence that degeneration of the nucleus basalis of Meynert precedes and predicts the onset of cognitive impairment, and might be used in a clinical setting as a reliable biomarker to stratify patients at higher risk of cognitive decline.</description><subject>Aged</subject><subject>Basal Nucleus of Meynert - diagnostic imaging</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cognitive Dysfunction - diagnostic imaging</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Diffusion Tensor Imaging</subject><subject>Female</subject><subject>Gray Matter - diagnostic imaging</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve Degeneration - diagnostic imaging</subject><subject>Nerve Degeneration - etiology</subject><subject>Neuropsychological Tests</subject><subject>Original</subject><subject>Parkinson Disease - complications</subject><issn>0006-8950</issn><issn>1460-2156</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNp9kctv1DAQxi0EotuFG2fkWzk0dOx44-SChKq-pPI4tGfLj_FiSOxgJ0X735N2SwUXTjOj-embx0fIGwbvGXT1ick6xBP9aweSPyMrJhqoONs0z8kKAJqq7TZwQA5L-Q7ARM2bl-SAdxKYbOWKhM-z7XEu1Oii-1Bo8vQT7iLmiTrc4pLoKaRIx4wWHRaqo7svXLBToTZtY5jCHdIwjDrkAeNEQ6Rfdf4RYknxqFAXCuqCr8gLr_uCrx_jmtyen92cXlbXXy6uTj9eV1a0fKosNAa45m1rhDNCd77DDVgprPTANp1nBpE3tfReGOG1acRyiodWeudsa-s1-bDXHWczoLPLRln3asxh0Hmnkg7q304M39Q23amGScZZuwi8exTI6eeMZVJDKBb7XkdMc1Ecai5qKZfnr8nxHrU5lZLRP41hoO7dUQ_uqL07C_7279We4D92LMDRHkjz-H-p3yS-njE</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Schulz, Jonathan</creator><creator>Pagano, Gennaro</creator><creator>Fernández Bonfante, Juan Alberto</creator><creator>Wilson, Heather</creator><creator>Politis, Marios</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8530-7113</orcidid><orcidid>https://orcid.org/0000-0002-6247-8988</orcidid></search><sort><creationdate>20180501</creationdate><title>Nucleus basalis of Meynert degeneration precedes and predicts cognitive impairment in Parkinson's disease</title><author>Schulz, Jonathan ; Pagano, Gennaro ; Fernández Bonfante, Juan Alberto ; Wilson, Heather ; Politis, Marios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-c06b02a288b4db4a9f9e50c74c7f0159f1bee2637ff4b4fab64017f087fddc8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Basal Nucleus of Meynert - diagnostic imaging</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cognitive Dysfunction - diagnostic imaging</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Diffusion Tensor Imaging</topic><topic>Female</topic><topic>Gray Matter - diagnostic imaging</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nerve Degeneration - diagnostic imaging</topic><topic>Nerve Degeneration - etiology</topic><topic>Neuropsychological Tests</topic><topic>Original</topic><topic>Parkinson Disease - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schulz, Jonathan</creatorcontrib><creatorcontrib>Pagano, Gennaro</creatorcontrib><creatorcontrib>Fernández Bonfante, Juan Alberto</creatorcontrib><creatorcontrib>Wilson, Heather</creatorcontrib><creatorcontrib>Politis, Marios</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain (London, England : 1878)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schulz, Jonathan</au><au>Pagano, Gennaro</au><au>Fernández Bonfante, Juan Alberto</au><au>Wilson, Heather</au><au>Politis, Marios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleus basalis of Meynert degeneration precedes and predicts cognitive impairment in Parkinson's disease</atitle><jtitle>Brain (London, England : 1878)</jtitle><addtitle>Brain</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>141</volume><issue>5</issue><spage>1501</spage><epage>1516</epage><pages>1501-1516</pages><issn>0006-8950</issn><issn>1460-2156</issn><eissn>1460-2156</eissn><abstract>There are currently no reliable predictors of cognitive impairment in Parkinson's disease. Using both cross-sectional and longitudinal comparisons, Schulz et al. report that grey matter volume loss and increased mean diffusivity in the nucleus basalis of Meynert is predictive of cognitive impairment in Parkinson's disease.
Abstract
Currently, no reliable predictors of cognitive impairment in Parkinson's disease exist. We hypothesized that microstructural changes at grey matter T1-weighted MRI and diffusion tensor imaging in the cholinergic system nuclei and associated limbic pathways underlie cognitive impairment in Parkinson's disease. We performed a cross-sectional comparison between patients with Parkinson's disease with and without cognitive impairment. We also performed a longitudinal 36-month follow-up study of cognitively intact Parkinson's disease patients, comparing patients who remained cognitively intact to those who developed cognitive impairment. Patients with Parkinson's disease with cognitive impairment showed lower grey matter volume and increased mean diffusivity in the nucleus basalis of Meynert, compared to patients with Parkinson's disease without cognitive impairment. These results were confirmed both with region of interest and voxel-based analyses, and after partial volume correction. Lower grey matter volume and increased mean diffusivity in the nucleus basalis of Meynert was predictive for developing cognitive impairment in cognitively intact patients with Parkinson's disease, independent of other clinical and non-clinical markers of the disease. Structural and microstructural alterations in entorhinal cortex, amygdala, hippocampus, insula, and thalamus were not predictive for developing cognitive impairment in Parkinson's disease. Our findings provide evidence that degeneration of the nucleus basalis of Meynert precedes and predicts the onset of cognitive impairment, and might be used in a clinical setting as a reliable biomarker to stratify patients at higher risk of cognitive decline.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>29701787</pmid><doi>10.1093/brain/awy072</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-8530-7113</orcidid><orcidid>https://orcid.org/0000-0002-6247-8988</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8950 |
| ispartof | Brain (London, England : 1878), 2018-05, Vol.141 (5), p.1501-1516 |
| issn | 0006-8950 1460-2156 1460-2156 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6171218 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Basal Nucleus of Meynert - diagnostic imaging Cerebral Cortex - diagnostic imaging Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - etiology Diffusion Tensor Imaging Female Gray Matter - diagnostic imaging Humans Image Processing, Computer-Assisted Male Middle Aged Nerve Degeneration - diagnostic imaging Nerve Degeneration - etiology Neuropsychological Tests Original Parkinson Disease - complications |
| title | Nucleus basalis of Meynert degeneration precedes and predicts cognitive impairment in Parkinson's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T04%3A15%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nucleus%20basalis%20of%20Meynert%20degeneration%20precedes%20and%20predicts%20cognitive%20impairment%20in%20Parkinson's%20disease&rft.jtitle=Brain%20(London,%20England%20:%201878)&rft.au=Schulz,%20Jonathan&rft.date=2018-05-01&rft.volume=141&rft.issue=5&rft.spage=1501&rft.epage=1516&rft.pages=1501-1516&rft.issn=0006-8950&rft.eissn=1460-2156&rft_id=info:doi/10.1093/brain/awy072&rft_dat=%3Cproquest_pubme%3E2032437709%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2032437709&rft_id=info:pmid/29701787&rft_oup_id=10.1093/brain/awy072&rfr_iscdi=true |