MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

Inflammation resolution counterbalances excessive inflammation and restores tissue homeostasis after injury. Failure of resolution contributes to the pathology of numerous chronic inflammatory diseases. Resolution is mediated by endogenous specialized proresolving mediators (SPMs), which are derived...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science signaling 2018-09, Vol.11 (549)
Hauptverfasser:	Cai, Bishuang, Kasikara, Canan, Doran, Amanda C, Ramakrishnan, Rajasekhar, Birge, Raymond B, Tabas, Ira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonate 5-Lipoxygenase - metabolism Biosynthesis c-Mer Tyrosine Kinase - metabolism Ca2+-transporting ATPase Ca2+/calmodulin-dependent protein kinase II Calcium Calcium (reticular) Calcium - metabolism Calcium ions Calcium-binding protein Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Calmodulin Cell activation Counterbalances Cytoplasm - metabolism Cytosol - metabolism Endoplasmic reticulum Enzyme Activation Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Exudates Exudation Fatty acids Gene expression Gene Expression Regulation, Enzymologic HEK293 Cells Homeostasis Humans Inflammation Inflammation Mediators - metabolism Inflammatory diseases Inhibition Intercellular Signaling Peptides and Proteins - metabolism Jurkat Cells Kinases Leukocytes (neutrophilic) Lipoxygenase Liquid oxygen Localization Macrophages Macrophages - cytology Macrophages - metabolism MAP kinase Metabolic pathways Mice Mice, Inbred C57BL Monocytes - cytology Neutrophils - metabolism Nuclear transport Peritonitis Peritonitis - metabolism Phosphorylation Proteins Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Signal Transduction Signaling Translocation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!