A1899, PK‐THPP, ML365, and Doxapram inhibit endogenous TASK channels and excite calcium signaling in carotid body type‐1 cells

Sensing of hypoxia and acidosis in arterial chemoreceptors is thought to be mediated through the inhibition of TASK and possibly other (e.g., BKCa) potassium channels which leads to membrane depolarization, voltage‐gated Ca‐entry, and neurosecretion. Here, we investigate the effects of pharmacologic...

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Veröffentlicht in:	Physiological reports 2018-09, Vol.6 (19), p.e13876-n/a
Hauptverfasser:	O'Donohoe, Peadar B., Huskens, Nicky, Turner, Philip J., Pandit, Jaideep J., Buckler, Keith J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Animals Animals, Newborn Benzamides - pharmacology Benzeneacetamides - pharmacology Calcium (intracellular) Calcium channels Calcium channels (voltage-gated) Calcium Signaling - drug effects Calcium Signaling - physiology Calcium signalling Carotid body Carotid Body - cytology Carotid Body - drug effects Carotid Body - physiology Channel gating Chemoreceptors (internal) Depolarization Doxapram - pharmacology HEK293 Cells Humans Hypotheses Hypoxia Kcnk3 Kcnk9 Membrane potential Neonates Nerve Tissue Proteins Neurosecretion Original Research Physiology Potassium Potassium Channels Potassium channels (calcium-gated) Potassium channels (voltage-gated) Potassium Channels, Tandem Pore Domain - antagonists & inhibitors Potassium Channels, Tandem Pore Domain - metabolism Rats Rats, Sprague-Dawley Respiratory System Agents - pharmacology TASK Ventilators
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