A post-ingestive amino acid sensor promotes food consumption in Drosophila

Adequate protein intake is crucial for the survival and well-being of animals. How animals assess prospective protein sources and ensure dietary amino acid intake plays a critical role in protein homeostasis. By using a quantitative feeding assay, we show that three amino acids, L-glutamate (L-Glu),...

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Veröffentlicht in:	Cell research 2018-10, Vol.28 (10), p.1013-1025
Hauptverfasser:	Yang, Zhe, Huang, Rui, Fu, Xin, Wang, Gaohang, Qi, Wei, Mao, Decai, Shi, Zhaomei, Shen, Wei L., Wang, Liming
Format:	Artikel
Sprache:	eng
Schlagworte:	14/1 14/19 38/91 45/70 631/337/2019 631/80/86 64/24 Alanine Alanine - metabolism Alanine - pharmacology Amino acids Amino Acids - metabolism Amino Acids - pharmacology Animals Aspartic Acid - metabolism Aspartic Acid - pharmacology Biomedical and Life Sciences Brain Calcium Calcium (dietary) Calcium - metabolism Cell Biology Deactivation Drosophila - physiology Drosophila Proteins - antagonists & inhibitors Drosophila Proteins - genetics Drosophila Proteins - metabolism Eating Enantiomers Feeding Feeding Behavior - drug effects Female Food Food consumption Food intake Fruit flies Gene expression Glutamic acid Glutamic Acid - metabolism Glutamic Acid - pharmacology Homeostasis Inactivation Insect Hormones - genetics Insect Hormones - metabolism Insects L-Alanine Life Sciences Male Nervous system Neurons Neurons - metabolism Nutritional Status Protein sources Proteins RNA Interference RNA, Small Interfering - metabolism Sensors Transcriptome Well being
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