CPP-Ts: a new intracellular calcium channel modulator and a promising tool for drug delivery in cancer cells

Scorpion sting envenoming impacts millions of people worldwide, with cardiac effects being one of the main causes of death on victims. Here we describe the first Ca 2+ channel toxin present in Tityus serrulatus ( Ts ) venom, a cell penetrating peptide (CPP) named CPP-Ts. We show that CPP-Ts increase...

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Veröffentlicht in:	Scientific reports 2018-10, Vol.8 (1), p.14739-13, Article 14739
Hauptverfasser:	Oliveira-Mendes, Bárbara Bruna Ribeiro de, Horta, Carolina Campolina Rebello, do Carmo, Anderson Oliveira, Biscoto, Gabriela Lago, Sales-Medina, Douglas Ferreira, Leal, Hortênsia Gomes, Brandão-Dias, Pedro Ferreira Pinto, Miranda, Sued Eustáquio Mendes, Aguiar, Carla Jeane, Cardoso, Valbert Nascimento, de Barros, André Luis Branco, Chávez-Olortégui, Carlos, Leite, M. Fátima, Kalapothakis, Evanguedes
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 14 14/19 45 45/90 45/91 631/154/152 631/443/810 82/29 96/95 Biotechnology Calcium (intracellular) Calcium channels Cancer Cardiomyocytes Contraction Drug delivery Drug delivery systems Humanities and Social Sciences Inositol 1,4,5-trisphosphate receptors Intracellular multidisciplinary Science Science (multidisciplinary) Toxins Tumor cell lines Venom
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