Gut Colonization with Methanogenic Archaea Lowers Plasma Trimethylamine N-oxide Concentrations in Apolipoprotein e−/− Mice

A mechanistic link between trimethylamine N-oxide (TMAO) and atherogenesis has been reported. TMAO is generated enzymatically in the liver by the oxidation of trimethylamine (TMA), which is produced from dietary choline, carnitine and betaine by gut bacteria. It is known that certain members of meth...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2018-10, Vol.8 (1), p.14752-11, Article 14752
Hauptverfasser:	Ramezani, Ali, Nolin, Thomas D., Barrows, Ian R., Serrano, Myrna G., Buck, Gregory A., Regunathan-Shenk, Renu, West, Raymond E., Latham, Patricia S., Amdur, Richard, Raj, Dominic S.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14 45 45/22 45/77 64 64/60 692/308 692/308/575 Administration, Oral Amines Animals Antibiotics Aorta Aorta - metabolism Aorta - microbiology Aorta - pathology Apolipoprotein E Apolipoproteins E - deficiency Apolipoproteins E - drug effects Apolipoproteins E - genetics Arteriosclerosis Atherogenesis Atherosclerosis - microbiology Atherosclerosis - prevention & control Betaine Carnitine Choline Choline - administration & dosage Choline - metabolism Colonization Diet Dietary Supplements Fecal microflora Feces - microbiology Female Gastrointestinal Microbiome - physiology Humanities and Social Sciences Liver Methane - metabolism Methanobrevibacter - growth & development Methanobrevibacter - metabolism Methanobrevibacter smithii Methanogenic archaea Methanomicrococcus blatticola Methanosarcina - growth & development Methanosarcina - metabolism Methanosarcina mazei Methylamines - administration & dosage Methylamines - blood Methylamines - metabolism Mice Mice, Inbred C57BL Mice, Knockout Microbial activity Microbial Consortia - physiology multidisciplinary Oxidation Plaque, Atherosclerotic - microbiology Plaque, Atherosclerotic - prevention & control Plaques Plasma Science Science (multidisciplinary) Transplantation Trimethylamine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!