Structural characterization and RAW264.7 murine macrophage stimulating activity of a fucogalactoglucan from Colpomenia peregrina
Water-soluble polysaccharides were isolated from Colpomenia peregrina to determine their chemical characteristics and immunomodulatory properties. High extraction yields were obtained for CP 1 (17.6%) and CP 2 (5.2%) polysaccharides. Polysaccharides were mainly consisted of neutral sugars (67.01–73....
Gespeichert in:
| Veröffentlicht in: | Journal of food science and technology 2018-11, Vol.55 (11), p.4650-4660 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4660 |
|---|---|
| container_issue | 11 |
| container_start_page | 4650 |
| container_title | Journal of food science and technology |
| container_volume | 55 |
| creator | Rostami, Zeynab Tabarsa, Mehdi You, SangGuan Rezaei, Masoud |
| description | Water-soluble polysaccharides were isolated from
Colpomenia peregrina
to determine their chemical characteristics and immunomodulatory properties. High extraction yields were obtained for CP
1
(17.6%) and CP
2
(5.2%) polysaccharides. Polysaccharides were mainly consisted of neutral sugars (67.01–73.79%), uronic acids (9.43–14.89%), proteins (3.44–14.89%) and small amounts of sulfates (4.87–4.91%). Polysaccharides were composed of fucose (20.62–24.56%), galactose (25.5–26.94%) and glucose (50.00–52.91%) residues. The average molecular weights of the CP
1
and CP
2
polysaccharides were 1890 × 10
3
g/mol and 639 × 10
3
g/mol, respectively. The polysaccharides exerted a relatively low cytotoxicity against HeLa cancer cells ( |
| doi_str_mv | 10.1007/s13197-018-3406-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6170361</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2103359327</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-94cfb16793a3fb1b89f4bd534d2cf276f7b7af51f3f03c5385db6109e9ac8bc3</originalsourceid><addsrcrecordid>eNp1kctq3TAQhk1paUKaB-imCLrpxqkulmVvCuHQGwQKbaBLMZYlHwVbciUrkK766J3DSdMLVBsNmm_-0cxfVc8ZvWCUqteZCdarmrKuFg1ta_moOqW9knXXUP4YY8p5zZiUJ9V5zjcUj-Cq4_RpdSKoEKJt-Wn148uWitlKgpmYPSQwm03-O2w-BgJhJJ8vv_K2uVBkKckHSxYwKa57mCzJm1_KjGiYCNb5W7_dkegIEFdMnGDGxzjNxUAgLsWF7OK8xsUGD2S1yU4oCM-qJw7mbM_v77Pq-t3b692H-urT-4-7y6vaNIpudd8YN7BW9QIEBkPXu2YYpWhGbhxXrVODAieZE44KI0Unx6FltLc9mG4w4qx6c5Rdy7DY0diw4ch6TX6BdKcjeP13Jvi9nuKtbpmiomUo8OpeIMVvxeZNLz4bO88QbCxZc8a57CUagOjLf9CbWFLA6ZDCzcsejUCKHSncZ87JuofPMKoPDuujwxod1geH9UH5xZ9TPFT88hMBfgQypsJk0-_W_1f9CbjytBQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2103359327</pqid></control><display><type>article</type><title>Structural characterization and RAW264.7 murine macrophage stimulating activity of a fucogalactoglucan from Colpomenia peregrina</title><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Rostami, Zeynab ; Tabarsa, Mehdi ; You, SangGuan ; Rezaei, Masoud</creator><creatorcontrib>Rostami, Zeynab ; Tabarsa, Mehdi ; You, SangGuan ; Rezaei, Masoud</creatorcontrib><description>Water-soluble polysaccharides were isolated from
Colpomenia peregrina
to determine their chemical characteristics and immunomodulatory properties. High extraction yields were obtained for CP
1
(17.6%) and CP
2
(5.2%) polysaccharides. Polysaccharides were mainly consisted of neutral sugars (67.01–73.79%), uronic acids (9.43–14.89%), proteins (3.44–14.89%) and small amounts of sulfates (4.87–4.91%). Polysaccharides were composed of fucose (20.62–24.56%), galactose (25.5–26.94%) and glucose (50.00–52.91%) residues. The average molecular weights of the CP
1
and CP
2
polysaccharides were 1890 × 10
3
g/mol and 639 × 10
3
g/mol, respectively. The polysaccharides exerted a relatively low cytotoxicity against HeLa cancer cells (< 40%). The CP
1
and CP
2
polysaccharides were nontoxic and induced RAW264.7 murine macrophage cells to release considerable amounts of nitric oxide (NO). Inflammatory cytokines including IL-1β, TNF-α, IL-6, IL-10 and IL-12 from were secreted from RAW264.7 cells induced with CP
1
polysaccharides. As the most immunostimulating fraction, CP
1
polysaccharides were homogeneous and formed of 1,3-linked galactose, 1,4-linked glucose and 1,3-linked fucose residues. Overall, these findings suggested that the polysaccharides isolated from
C. peregrina
can be utilized as potential natural immunostimulant in functional foods or pharmaceutical industries.</description><identifier>ISSN: 0022-1155</identifier><identifier>EISSN: 0975-8402</identifier><identifier>DOI: 10.1007/s13197-018-3406-5</identifier><identifier>PMID: 30333662</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Cancer ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Colpomenia peregrina ; Cytokines ; Cytotoxicity ; Food industry ; Food Science ; Fucose ; Functional foods & nutraceuticals ; Galactose ; Glucose ; Immunomodulation ; Immunostimulants ; Inflammation ; Interleukin 10 ; Interleukin 12 ; Interleukin 6 ; Macrophages ; Nitric oxide ; Nutrition ; Organic chemistry ; Original ; Original Article ; Pharmaceutical industry ; Polysaccharides ; Proteins ; Residues ; Saccharides ; Structural analysis ; Studies ; Sugar ; Toxicity ; Tumor necrosis factor-α</subject><ispartof>Journal of food science and technology, 2018-11, Vol.55 (11), p.4650-4660</ispartof><rights>Association of Food Scientists & Technologists (India) 2018</rights><rights>Journal of Food Science and Technology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-94cfb16793a3fb1b89f4bd534d2cf276f7b7af51f3f03c5385db6109e9ac8bc3</citedby><cites>FETCH-LOGICAL-c470t-94cfb16793a3fb1b89f4bd534d2cf276f7b7af51f3f03c5385db6109e9ac8bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170361/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170361/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30333662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rostami, Zeynab</creatorcontrib><creatorcontrib>Tabarsa, Mehdi</creatorcontrib><creatorcontrib>You, SangGuan</creatorcontrib><creatorcontrib>Rezaei, Masoud</creatorcontrib><title>Structural characterization and RAW264.7 murine macrophage stimulating activity of a fucogalactoglucan from Colpomenia peregrina</title><title>Journal of food science and technology</title><addtitle>J Food Sci Technol</addtitle><addtitle>J Food Sci Technol</addtitle><description>Water-soluble polysaccharides were isolated from
Colpomenia peregrina
to determine their chemical characteristics and immunomodulatory properties. High extraction yields were obtained for CP
1
(17.6%) and CP
2
(5.2%) polysaccharides. Polysaccharides were mainly consisted of neutral sugars (67.01–73.79%), uronic acids (9.43–14.89%), proteins (3.44–14.89%) and small amounts of sulfates (4.87–4.91%). Polysaccharides were composed of fucose (20.62–24.56%), galactose (25.5–26.94%) and glucose (50.00–52.91%) residues. The average molecular weights of the CP
1
and CP
2
polysaccharides were 1890 × 10
3
g/mol and 639 × 10
3
g/mol, respectively. The polysaccharides exerted a relatively low cytotoxicity against HeLa cancer cells (< 40%). The CP
1
and CP
2
polysaccharides were nontoxic and induced RAW264.7 murine macrophage cells to release considerable amounts of nitric oxide (NO). Inflammatory cytokines including IL-1β, TNF-α, IL-6, IL-10 and IL-12 from were secreted from RAW264.7 cells induced with CP
1
polysaccharides. As the most immunostimulating fraction, CP
1
polysaccharides were homogeneous and formed of 1,3-linked galactose, 1,4-linked glucose and 1,3-linked fucose residues. Overall, these findings suggested that the polysaccharides isolated from
C. peregrina
can be utilized as potential natural immunostimulant in functional foods or pharmaceutical industries.</description><subject>Cancer</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Colpomenia peregrina</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Food industry</subject><subject>Food Science</subject><subject>Fucose</subject><subject>Functional foods & nutraceuticals</subject><subject>Galactose</subject><subject>Glucose</subject><subject>Immunomodulation</subject><subject>Immunostimulants</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Interleukin 12</subject><subject>Interleukin 6</subject><subject>Macrophages</subject><subject>Nitric oxide</subject><subject>Nutrition</subject><subject>Organic chemistry</subject><subject>Original</subject><subject>Original Article</subject><subject>Pharmaceutical industry</subject><subject>Polysaccharides</subject><subject>Proteins</subject><subject>Residues</subject><subject>Saccharides</subject><subject>Structural analysis</subject><subject>Studies</subject><subject>Sugar</subject><subject>Toxicity</subject><subject>Tumor necrosis factor-α</subject><issn>0022-1155</issn><issn>0975-8402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kctq3TAQhk1paUKaB-imCLrpxqkulmVvCuHQGwQKbaBLMZYlHwVbciUrkK766J3DSdMLVBsNmm_-0cxfVc8ZvWCUqteZCdarmrKuFg1ta_moOqW9knXXUP4YY8p5zZiUJ9V5zjcUj-Cq4_RpdSKoEKJt-Wn148uWitlKgpmYPSQwm03-O2w-BgJhJJ8vv_K2uVBkKckHSxYwKa57mCzJm1_KjGiYCNb5W7_dkegIEFdMnGDGxzjNxUAgLsWF7OK8xsUGD2S1yU4oCM-qJw7mbM_v77Pq-t3b692H-urT-4-7y6vaNIpudd8YN7BW9QIEBkPXu2YYpWhGbhxXrVODAieZE44KI0Unx6FltLc9mG4w4qx6c5Rdy7DY0diw4ch6TX6BdKcjeP13Jvi9nuKtbpmiomUo8OpeIMVvxeZNLz4bO88QbCxZc8a57CUagOjLf9CbWFLA6ZDCzcsejUCKHSncZ87JuofPMKoPDuujwxod1geH9UH5xZ9TPFT88hMBfgQypsJk0-_W_1f9CbjytBQ</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Rostami, Zeynab</creator><creator>Tabarsa, Mehdi</creator><creator>You, SangGuan</creator><creator>Rezaei, Masoud</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>04Q</scope><scope>04S</scope><scope>04W</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7QR</scope><scope>7RQ</scope><scope>7ST</scope><scope>7T7</scope><scope>7TM</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X2</scope><scope>7XB</scope><scope>87Z</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FK</scope><scope>8FL</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>F~G</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>L.-</scope><scope>L6V</scope><scope>M0C</scope><scope>M0K</scope><scope>M7S</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>Q9U</scope><scope>SOI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181101</creationdate><title>Structural characterization and RAW264.7 murine macrophage stimulating activity of a fucogalactoglucan from Colpomenia peregrina</title><author>Rostami, Zeynab ; Tabarsa, Mehdi ; You, SangGuan ; Rezaei, Masoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-94cfb16793a3fb1b89f4bd534d2cf276f7b7af51f3f03c5385db6109e9ac8bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cancer</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Colpomenia peregrina</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Food industry</topic><topic>Food Science</topic><topic>Fucose</topic><topic>Functional foods & nutraceuticals</topic><topic>Galactose</topic><topic>Glucose</topic><topic>Immunomodulation</topic><topic>Immunostimulants</topic><topic>Inflammation</topic><topic>Interleukin 10</topic><topic>Interleukin 12</topic><topic>Interleukin 6</topic><topic>Macrophages</topic><topic>Nitric oxide</topic><topic>Nutrition</topic><topic>Organic chemistry</topic><topic>Original</topic><topic>Original Article</topic><topic>Pharmaceutical industry</topic><topic>Polysaccharides</topic><topic>Proteins</topic><topic>Residues</topic><topic>Saccharides</topic><topic>Structural analysis</topic><topic>Studies</topic><topic>Sugar</topic><topic>Toxicity</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rostami, Zeynab</creatorcontrib><creatorcontrib>Tabarsa, Mehdi</creatorcontrib><creatorcontrib>You, SangGuan</creatorcontrib><creatorcontrib>Rezaei, Masoud</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>India Database</collection><collection>India Database: Business</collection><collection>India Database: Science & Technology</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Access via ABI/INFORM (ProQuest)</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ProQuest Engineering Collection</collection><collection>ABI/INFORM Global</collection><collection>Agricultural Science Database</collection><collection>Engineering Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>ProQuest Central Basic</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of food science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rostami, Zeynab</au><au>Tabarsa, Mehdi</au><au>You, SangGuan</au><au>Rezaei, Masoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural characterization and RAW264.7 murine macrophage stimulating activity of a fucogalactoglucan from Colpomenia peregrina</atitle><jtitle>Journal of food science and technology</jtitle><stitle>J Food Sci Technol</stitle><addtitle>J Food Sci Technol</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>55</volume><issue>11</issue><spage>4650</spage><epage>4660</epage><pages>4650-4660</pages><issn>0022-1155</issn><eissn>0975-8402</eissn><abstract>Water-soluble polysaccharides were isolated from
Colpomenia peregrina
to determine their chemical characteristics and immunomodulatory properties. High extraction yields were obtained for CP
1
(17.6%) and CP
2
(5.2%) polysaccharides. Polysaccharides were mainly consisted of neutral sugars (67.01–73.79%), uronic acids (9.43–14.89%), proteins (3.44–14.89%) and small amounts of sulfates (4.87–4.91%). Polysaccharides were composed of fucose (20.62–24.56%), galactose (25.5–26.94%) and glucose (50.00–52.91%) residues. The average molecular weights of the CP
1
and CP
2
polysaccharides were 1890 × 10
3
g/mol and 639 × 10
3
g/mol, respectively. The polysaccharides exerted a relatively low cytotoxicity against HeLa cancer cells (< 40%). The CP
1
and CP
2
polysaccharides were nontoxic and induced RAW264.7 murine macrophage cells to release considerable amounts of nitric oxide (NO). Inflammatory cytokines including IL-1β, TNF-α, IL-6, IL-10 and IL-12 from were secreted from RAW264.7 cells induced with CP
1
polysaccharides. As the most immunostimulating fraction, CP
1
polysaccharides were homogeneous and formed of 1,3-linked galactose, 1,4-linked glucose and 1,3-linked fucose residues. Overall, these findings suggested that the polysaccharides isolated from
C. peregrina
can be utilized as potential natural immunostimulant in functional foods or pharmaceutical industries.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>30333662</pmid><doi>10.1007/s13197-018-3406-5</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1155 |
| ispartof | Journal of food science and technology, 2018-11, Vol.55 (11), p.4650-4660 |
| issn | 0022-1155 0975-8402 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6170361 |
| source | EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Cancer Chemistry Chemistry and Materials Science Chemistry/Food Science Colpomenia peregrina Cytokines Cytotoxicity Food industry Food Science Fucose Functional foods & nutraceuticals Galactose Glucose Immunomodulation Immunostimulants Inflammation Interleukin 10 Interleukin 12 Interleukin 6 Macrophages Nitric oxide Nutrition Organic chemistry Original Original Article Pharmaceutical industry Polysaccharides Proteins Residues Saccharides Structural analysis Studies Sugar Toxicity Tumor necrosis factor-α |
| title | Structural characterization and RAW264.7 murine macrophage stimulating activity of a fucogalactoglucan from Colpomenia peregrina |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T12%3A23%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structural%20characterization%20and%20RAW264.7%20murine%20macrophage%20stimulating%20activity%20of%20a%20fucogalactoglucan%20from%20Colpomenia%20peregrina&rft.jtitle=Journal%20of%20food%20science%20and%20technology&rft.au=Rostami,%20Zeynab&rft.date=2018-11-01&rft.volume=55&rft.issue=11&rft.spage=4650&rft.epage=4660&rft.pages=4650-4660&rft.issn=0022-1155&rft.eissn=0975-8402&rft_id=info:doi/10.1007/s13197-018-3406-5&rft_dat=%3Cproquest_pubme%3E2103359327%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2103359327&rft_id=info:pmid/30333662&rfr_iscdi=true |