Gene Regulatory Network Analysis Identifies Sex-Linked Differences in Colon Cancer Drug Metabolism

Understanding sex differences in colon cancer is essential to advance disease prevention, diagnosis, and treatment. Males have a higher risk of developing colon cancer and a lower survival rate than women. However, the molecular features that drive these sex differences are poorly understood. In thi...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-10, Vol.78 (19), p.5538-5547
Hauptverfasser:	Lopes-Ramos, Camila M, Kuijjer, Marieke L, Ogino, Shuji, Fuchs, Charles S, DeMeo, Dawn L, Glass, Kimberly, Quackenbush, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antineoplastic Agents - pharmacology Biomarkers, Tumor - genetics Chemotherapy, Adjuvant Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Cytochrome P-450 Enzyme System - metabolism Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genome, Human Humans Kaplan-Meier Estimate Male Middle Aged Principal Component Analysis Sex Factors Treatment Outcome
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