Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Natural Killer Cells in Vaccination
Natural killer (NK) cells have historically been considered to be a part of the innate immune system, exerting a rapid response against pathogens and tumors in an antigen (Ag)-independent manner. However, over the past decade, evidence has accumulated suggesting that at least some NK cells display c...
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| Veröffentlicht in: | Cold Spring Harbor perspectives in biology 2018-10, Vol.10 (10), p.a029488 |
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| description | Natural killer (NK) cells have historically been considered to be a part of the innate immune system, exerting a rapid response against pathogens and tumors in an antigen (Ag)-independent manner. However, over the past decade, evidence has accumulated suggesting that at least some NK cells display certain characteristics of adaptive immune cells. Indeed, NK cells can learn and remember encounters with a variety of Ags, including chemical haptens and viruses. Upon rechallenge, memory NK cells mount potent recall responses selectively to those Ags. This phenomenon, traditionally termed "immunological memory," has been reported in mice, nonhuman primates, and even humans and appears to be concentrated in discrete NK cell subsets. Because immunological memory protects against recurrent infections and is the central goal of active vaccination, it is crucial to define the mechanisms and consequences of NK cell memory. Here, we summarize the different kinds of memory responses that have been attributed to specific NK cell subsets and discuss the possibility to harness NK cell memory for vaccination purposes. |
| doi_str_mv | 10.1101/cshperspect.a029488 |
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This phenomenon, traditionally termed "immunological memory," has been reported in mice, nonhuman primates, and even humans and appears to be concentrated in discrete NK cell subsets. Because immunological memory protects against recurrent infections and is the central goal of active vaccination, it is crucial to define the mechanisms and consequences of NK cell memory. 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Natural Killer Cells in Vaccination</title><title>Cold Spring Harbor perspectives in biology</title><addtitle>Cold Spring Harb Perspect Biol</addtitle><description>Natural killer (NK) cells have historically been considered to be a part of the innate immune system, exerting a rapid response against pathogens and tumors in an antigen (Ag)-independent manner. However, over the past decade, evidence has accumulated suggesting that at least some NK cells display certain characteristics of adaptive immune cells. Indeed, NK cells can learn and remember encounters with a variety of Ags, including chemical haptens and viruses. Upon rechallenge, memory NK cells mount potent recall responses selectively to those Ags. This phenomenon, traditionally termed "immunological memory," has been reported in mice, nonhuman primates, and even humans and appears to be concentrated in discrete NK cell subsets. Because immunological memory protects against recurrent infections and is the central goal of active vaccination, it is crucial to define the mechanisms and consequences of NK cell memory. Here, we summarize the different kinds of memory responses that have been attributed to specific NK cell subsets and discuss the possibility to harness NK cell memory for vaccination purposes.</description><subject>Adaptive Immunity</subject><subject>Animals</subject><subject>Haptens</subject><subject>Historical account</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity, Innate</subject><subject>Immunologic Memory</subject><subject>Immunological memory</subject><subject>Immunology</subject><subject>Innate immunity</subject><subject>Killer Cells, Natural - physiology</subject><subject>Learning</subject><subject>Mushrooms</subject><subject>Natural killer cells</subject><subject>Organic chemistry</subject><subject>Primates</subject><subject>Tumors</subject><subject>Vaccination</subject><subject>Viruses</subject><issn>1943-0264</issn><issn>1943-0264</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU1rGzEQhkVJaD7aX1AIglx6saOv1WovCalJE9MkvZhehVYa1RvWkiPtFvzvq2I3OCGnGZhnXuadF6EvlEwpJfTC5uUaUl6DHaaGsEYo9QEd00bwCWFSHOz1R-gk5ydCpGyU_IiOWMMq0dTqGMV5xoslJMCPZhiT6fGPru8h4Rn0PX6AVUwbbILDMxPwfMDfAN-ZFCBncLjd4F_G2i6YoYvh6j2JjLuwD31Ch970GT7v6ilafL9ZzO4m9z9v57Pr-4nlXA2TWkrhai-9ddRRZanzpgXFlBKey9Y6paj1xFdOVrItZrggrWs85W1dNcBP0eVWdj22K3AWwlAO0-vUrUza6Gg6_XoSuqX-Hf9oScuLqCwCX3cCKT6PkAe96rIthkyAOGZNy_dqJohQBT1_gz7FMYXiTjPKZUWZYqJQfEvZFHNO4F-OoUT_y1Pv5al3eZats30fLzv_A-R_ARyaoFs</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Neely, Harold R</creator><creator>Mazo, Irina B</creator><creator>Gerlach, Carmen</creator><creator>von Andrian, Ulrich H</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181001</creationdate><title>Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? 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This phenomenon, traditionally termed "immunological memory," has been reported in mice, nonhuman primates, and even humans and appears to be concentrated in discrete NK cell subsets. Because immunological memory protects against recurrent infections and is the central goal of active vaccination, it is crucial to define the mechanisms and consequences of NK cell memory. Here, we summarize the different kinds of memory responses that have been attributed to specific NK cell subsets and discuss the possibility to harness NK cell memory for vaccination purposes.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>29254978</pmid><doi>10.1101/cshperspect.a029488</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptive Immunity Animals Haptens Historical account Humans Immune system Immunity, Innate Immunologic Memory Immunological memory Immunology Innate immunity Killer Cells, Natural - physiology Learning Mushrooms Natural killer cells Organic chemistry Primates Tumors Vaccination Viruses |
| title | Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Natural Killer Cells in Vaccination |
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