The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers

The chemokine CCL3 is frequently overexpressed in malignancies and overexpression leads to microenvironmental dysfunction. In murine models of chronic myelogenous leukemia (CML), CCL3 is critical for the maintenance of a leukemia stem cell population, and leukemia progression. With CCL3 implicated a...

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Veröffentlicht in:	Scientific reports 2018-10, Vol.8 (1), p.14691-9, Article 14691
Hauptverfasser:	Staversky, Rhonda J., Byun, Daniel K., Georger, Mary A., Zaffuto, Brandon J., Goodman, Alexandra, Becker, Michael W., Calvi, Laura M., Frisch, Benjamin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14 631/532/1542 631/80 Animal models Animals Blood cancer Bone marrow CCL3 protein Cell Count Cell Differentiation Chemokine CCL3 - deficiency Chemokine CCL3 - metabolism Chemokines Chronic myeloid leukemia Hematopoietic stem cells Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - physiology Homeostasis Humanities and Social Sciences Leukemia Malignancy Mice Mice, Knockout multidisciplinary Myeloid Cells - drug effects Myeloid Cells - physiology Myeloid leukemia Progenitor cells Rodents Science Science (multidisciplinary) Stem cells Therapeutic applications
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