Renoprotective effect of Zhenwu decoction against renal fibrosis by regulation of oxidative damage and energy metabolism disorder
Zhenwu decoction (ZWD) is a promising traditional Chinese prescription against renal fibrosis, while its underlying mechanism remains unclear. Rat model of renal fibrosis were established and divided into control group, model group, ZWD treatment group and enalapril maleate treatment group. Metaboli...
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| Veröffentlicht in: | Scientific reports 2018-10, Vol.8 (1), p.14627-11, Article 14627 |
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| description | Zhenwu decoction (ZWD) is a promising traditional Chinese prescription against renal fibrosis, while its underlying mechanism remains unclear. Rat model of renal fibrosis were established and divided into control group, model group, ZWD treatment group and enalapril maleate treatment group. Metabolic profiles on serum samples from each group were acquired by using ultra performance liquid chromatography coupled with quadrupole time-of-flight high-resolution mass spectrometry. Metabolomics combined with molecular biology were comparatively conducted on samples of various groups. Fifteen potential biomarkers were identified and these biomarkers are mainly phospholipids and fatty acids. The results showed renal fibrosis was associated with oxidative damage and energy metabolism disorder. The results of histopathology, biochemistry and metabolomics demonstrated that ZWD exhibited an efficient renoprotective effect by alleviating oxidative stress, increasing energy metabolism and regulating fibrotic cytokines. This study provided scientific support for the research and development of new drugs from traditional Chinese medicine. |
| doi_str_mv | 10.1038/s41598-018-32115-9 |
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Rat model of renal fibrosis were established and divided into control group, model group, ZWD treatment group and enalapril maleate treatment group. Metabolic profiles on serum samples from each group were acquired by using ultra performance liquid chromatography coupled with quadrupole time-of-flight high-resolution mass spectrometry. Metabolomics combined with molecular biology were comparatively conducted on samples of various groups. Fifteen potential biomarkers were identified and these biomarkers are mainly phospholipids and fatty acids. The results showed renal fibrosis was associated with oxidative damage and energy metabolism disorder. The results of histopathology, biochemistry and metabolomics demonstrated that ZWD exhibited an efficient renoprotective effect by alleviating oxidative stress, increasing energy metabolism and regulating fibrotic cytokines. This study provided scientific support for the research and development of new drugs from traditional Chinese medicine.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-32115-9</identifier><identifier>PMID: 30279506</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/58 ; 631/553 ; 692/699/1585/3182 ; Animals ; Biomarkers ; Biomarkers - metabolism ; Cytokines ; Drug development ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - therapeutic use ; Energy metabolism ; Energy Metabolism - drug effects ; Fatty acids ; Fibrosis ; Herbal medicine ; Histopathology ; Humanities and Social Sciences ; Kidney - pathology ; Kidney Failure, Chronic - drug therapy ; Kidney Failure, Chronic - pathology ; Kidneys ; Liquid chromatography ; Mass spectrometry ; Mass spectroscopy ; Medicine, Chinese Traditional ; Metabolic disorders ; Metabolome - drug effects ; Metabolomics ; Molecular biology ; multidisciplinary ; Oxidation ; Oxidative metabolism ; Oxidative stress ; Oxidative Stress - drug effects ; Phospholipids ; R&D ; Rats ; Rats, Sprague-Dawley ; Research & development ; Science ; Science (multidisciplinary) ; Traditional Chinese medicine</subject><ispartof>Scientific reports, 2018-10, Vol.8 (1), p.14627-11, Article 14627</ispartof><rights>The Author(s) 2018</rights><rights>2018. 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Rat model of renal fibrosis were established and divided into control group, model group, ZWD treatment group and enalapril maleate treatment group. Metabolic profiles on serum samples from each group were acquired by using ultra performance liquid chromatography coupled with quadrupole time-of-flight high-resolution mass spectrometry. Metabolomics combined with molecular biology were comparatively conducted on samples of various groups. Fifteen potential biomarkers were identified and these biomarkers are mainly phospholipids and fatty acids. The results showed renal fibrosis was associated with oxidative damage and energy metabolism disorder. The results of histopathology, biochemistry and metabolomics demonstrated that ZWD exhibited an efficient renoprotective effect by alleviating oxidative stress, increasing energy metabolism and regulating fibrotic cytokines. This study provided scientific support for the research and development of new drugs from traditional Chinese medicine.</description><subject>101/58</subject><subject>631/553</subject><subject>692/699/1585/3182</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Cytokines</subject><subject>Drug development</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Energy metabolism</subject><subject>Energy Metabolism - drug effects</subject><subject>Fatty acids</subject><subject>Fibrosis</subject><subject>Herbal medicine</subject><subject>Histopathology</subject><subject>Humanities and Social Sciences</subject><subject>Kidney - pathology</subject><subject>Kidney Failure, Chronic - drug therapy</subject><subject>Kidney Failure, Chronic - pathology</subject><subject>Kidneys</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medicine, Chinese Traditional</subject><subject>Metabolic disorders</subject><subject>Metabolome - drug effects</subject><subject>Metabolomics</subject><subject>Molecular biology</subject><subject>multidisciplinary</subject><subject>Oxidation</subject><subject>Oxidative metabolism</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Phospholipids</subject><subject>R&D</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Research & development</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Traditional Chinese medicine</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9rFjEQxoNYbGn7BTxIwIuX1SSb7GYvghSrQkEQvXgJ-TPZpuwmr8lu63vsNzd931qrB3PJMPObJ5l5EHpOyWtKWvmmcCoG2RAqm5ZRKprhCTpihIuGtYw9fRQfotNSrkg9gg2cDs_QYUtYPwjSHaHbLxDTJqcF7BKuAYP3NcLJ4--XEG9W7MCmWkoR61GHWBacIeoJ-2ByKqFgs62ZcZ30DqqN6Wdweifm9KxHwDo6DBHyuMUzLNqkKZQZu1BSdpBP0IHXU4HT-_sYfTt___XsY3Px-cOns3cXjeU9XxpGe5DWEAfccSuFNZ6CZzAA3OW0J8ZYLqwnneWd1LynXGpXJwavjYP2GL3d625WM4OzEJesJ7XJYdZ5q5IO6u9KDJdqTNeqo50ULasCr-4FcvqxQlnUHIqFadIR0lpUdaGjVPKOVvTlP-hVWnNd244SPet70VWK7SlbN1ky-IfPUKLuTFZ7k1U1We1MVkNtevF4jIeW35ZWoN0DpZbiCPnP2_-R_QXIL7c_</recordid><startdate>20181002</startdate><enddate>20181002</enddate><creator>Li, Shasha</creator><creator>Xiao, Xue</creator><creator>Han, Ling</creator><creator>Wang, Yiming</creator><creator>Luo, Guoan</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181002</creationdate><title>Renoprotective effect of Zhenwu decoction against renal fibrosis by regulation of oxidative damage and energy metabolism disorder</title><author>Li, Shasha ; Xiao, Xue ; Han, Ling ; Wang, Yiming ; Luo, Guoan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-217e8cb0de4d4c85cbf1ef2e9ee0de4af0bbc45cf06c468a47148ad294efabde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>101/58</topic><topic>631/553</topic><topic>692/699/1585/3182</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Cytokines</topic><topic>Drug development</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Energy metabolism</topic><topic>Energy Metabolism - drug effects</topic><topic>Fatty acids</topic><topic>Fibrosis</topic><topic>Herbal medicine</topic><topic>Histopathology</topic><topic>Humanities and Social Sciences</topic><topic>Kidney - pathology</topic><topic>Kidney Failure, Chronic - drug therapy</topic><topic>Kidney Failure, Chronic - pathology</topic><topic>Kidneys</topic><topic>Liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medicine, Chinese Traditional</topic><topic>Metabolic disorders</topic><topic>Metabolome - drug effects</topic><topic>Metabolomics</topic><topic>Molecular biology</topic><topic>multidisciplinary</topic><topic>Oxidation</topic><topic>Oxidative metabolism</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Phospholipids</topic><topic>R&D</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Research & development</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Traditional Chinese medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Shasha</creatorcontrib><creatorcontrib>Xiao, Xue</creatorcontrib><creatorcontrib>Han, Ling</creatorcontrib><creatorcontrib>Wang, Yiming</creatorcontrib><creatorcontrib>Luo, Guoan</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shasha</au><au>Xiao, Xue</au><au>Han, Ling</au><au>Wang, Yiming</au><au>Luo, Guoan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renoprotective effect of Zhenwu decoction against renal fibrosis by regulation of oxidative damage and energy metabolism disorder</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-10-02</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>14627</spage><epage>11</epage><pages>14627-11</pages><artnum>14627</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Zhenwu decoction (ZWD) is a promising traditional Chinese prescription against renal fibrosis, while its underlying mechanism remains unclear. Rat model of renal fibrosis were established and divided into control group, model group, ZWD treatment group and enalapril maleate treatment group. Metabolic profiles on serum samples from each group were acquired by using ultra performance liquid chromatography coupled with quadrupole time-of-flight high-resolution mass spectrometry. Metabolomics combined with molecular biology were comparatively conducted on samples of various groups. Fifteen potential biomarkers were identified and these biomarkers are mainly phospholipids and fatty acids. The results showed renal fibrosis was associated with oxidative damage and energy metabolism disorder. The results of histopathology, biochemistry and metabolomics demonstrated that ZWD exhibited an efficient renoprotective effect by alleviating oxidative stress, increasing energy metabolism and regulating fibrotic cytokines. This study provided scientific support for the research and development of new drugs from traditional Chinese medicine.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30279506</pmid><doi>10.1038/s41598-018-32115-9</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 101/58 631/553 692/699/1585/3182 Animals Biomarkers Biomarkers - metabolism Cytokines Drug development Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Energy metabolism Energy Metabolism - drug effects Fatty acids Fibrosis Herbal medicine Histopathology Humanities and Social Sciences Kidney - pathology Kidney Failure, Chronic - drug therapy Kidney Failure, Chronic - pathology Kidneys Liquid chromatography Mass spectrometry Mass spectroscopy Medicine, Chinese Traditional Metabolic disorders Metabolome - drug effects Metabolomics Molecular biology multidisciplinary Oxidation Oxidative metabolism Oxidative stress Oxidative Stress - drug effects Phospholipids R&D Rats Rats, Sprague-Dawley Research & development Science Science (multidisciplinary) Traditional Chinese medicine |
| title | Renoprotective effect of Zhenwu decoction against renal fibrosis by regulation of oxidative damage and energy metabolism disorder |
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