Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel

C-type inactivation is a time-dependent process observed in many K channels whereby prolonged activation by an external stimulus leads to a reduction in ionic conduction. While C-type inactivation is thought to be a result of a constriction of the selectivity filter, the local dynamics of the proces...

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Veröffentlicht in:	The Journal of general physiology 2018-10, Vol.150 (10), p.1408-1420
Hauptverfasser:	Li, Jing, Ostmeyer, Jared, Cuello, Luis G, Perozo, Eduardo, Roux, Benoît
Format:	Artikel
Sprache:	eng
Schlagworte:	Channel gating Conduction Conformation Intracellular Ions Potassium
Online-Zugang:	Volltext
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