Quantitative and qualitative iNKT repertoire associations with disease susceptibility and outcome in macaque tuberculosis infection

Abstract Correlates of immune protection that reliably predict vaccine efficacy against Mycobacterium tuberculosis (Mtb) infection are urgently needed. Invariant NKT cells (iNKTs) are CD1d-dependent innate T cells that augment host antimicrobial immunity through production of cytokines, including in...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2017-07, Vol.105, p.86-95
Hauptverfasser:	Chancellor, Andrew, White, Andrew, Tocheva, Anna S, Fenn, Joe R, Dennis, Mike, Tezera, Liku, Singhania, Akul, Elliott, Tim, Tebruegge, Marc, Elkington, Paul, Gadola, Stephan, Sharpe, Sally, Mansour, Salah
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD1d - blood Antigens, CD1d - immunology Antimicrobial agents Bacillus Calmette-Guerin vaccine BCG BCG Vaccine - administration & dosage CD1d CD1d antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - microbiology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - microbiology Cell Proliferation Cells, Cultured Correlates of protection Cytokines Cytokines - blood Cytokines - immunology Disease Models, Animal Galactosylceramide Galactosylceramides - pharmacology Genetic Predisposition to Disease Host-Pathogen Interactions Immune system Immunity Infections Infectious Disease iNKT Interferon Lung - immunology Lung - microbiology Lymphocyte Activation Lymphocytes Lymphocytes T Macaca fascicularis Macaca mulatta Macaque Mycobacterium tuberculosis - immunology Natural killer cells Natural Killer T-Cells - drug effects Natural Killer T-Cells - immunology Natural Killer T-Cells - microbiology Peripheral blood Phenotype Primates Pulmonary/Respiratory Species Specificity Tuberculosis Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - prevention & control Tumor necrosis factor-α Tumors Vaccination Vaccine efficacy Vaccines
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