Comprehensive analysis of the tumor immune micro-environment in non-small cell lung cancer for efficacy of checkpoint inhibitor

Characterizing the molecular immune subtype and micro-environment of lung cancer is necessary to understand immunogenic interactions between infiltrating immune and stromal cells, and how tumor cells overcome immune checkpoint blockades. This study seeks to identify computational methodologies for s...

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Veröffentlicht in:	Scientific reports 2018-10, Vol.8 (1), p.14576-14, Article 14576
Hauptverfasser:	Seo, Jeong-Sun, Kim, Ahreum, Shin, Jong-Yeon, Kim, Young Tae
Format:	Artikel
Sprache:	eng
Schlagworte:	38 45 45/91 631/250/251/1567 631/250/580/1884/2323 CD8 antigen Cell activation Computer applications Cytolytic activity Environmental factors Gene expression Humanities and Social Sciences Immune checkpoint inhibitors Immunogenicity Immunosuppression Lung cancer Lung carcinoma Lymphocytes B Lymphocytes T Macrophages multidisciplinary Non-small cell lung carcinoma Science Science (multidisciplinary) Squamous cell carcinoma Stromal cells Tumor cells Tumors
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