Structure–function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-κB

The closely related type III secretion system zinc metalloprotease effector proteins GtgA, GogA, and PipA are translocated into host cells during Salmonella infection. They then cleave nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) transcription factor subunits, dampening activat...

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Veröffentlicht in:	The Journal of biological chemistry 2018-09, Vol.293 (39), p.15316-15329
Hauptverfasser:	Jennings, Elliott, Esposito, Diego, Rittinger, Katrin, Thurston, Teresa L.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence - genetics bacterial effectors bacterial pathogenesis Crystallography, X-Ray Editors' Picks Escherichia coli - chemistry Escherichia coli - genetics Escherichia coli - pathogenicity GtgA HeLa Cells Humans Immunity, Cellular metalloprotease Metalloproteases - chemistry Metalloproteases - genetics NF-kappa B - chemistry NF-κB Protein Conformation Salmonella enterica Salmonella enterica - chemistry Salmonella enterica - genetics Salmonella enterica - pathogenicity Salmonella Infections - genetics Salmonella Infections - microbiology Signal Transduction Structure-Activity Relationship substrate specificity Transcription Factor RelA - chemistry type III secretion system (T3SS) Type III Secretion Systems - chemistry Type III Secretion Systems - genetics virulence factor Zinc - chemistry
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