The contribution of cross-talk between the cell-surface proteins CD36 and CD47–TSP-1 in osteoclast formation and function

Antibody-mediated blockade of cluster of differentiation 47 (CD47)–thrombospondin-1 (TSP-1) interactions blocks osteoclast formation in vitro and attenuates parathyroid hormone (PTH)-induced hypercalcemia in vivo in mice. Hypercalcemia in this model reflects increased bone resorption. TSP-1 has two...

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Veröffentlicht in:	The Journal of biological chemistry 2018-09, Vol.293 (39), p.15055-15069
Hauptverfasser:	Koduru, Srinivas V., Sun, Ben-hua, Walker, Joanne M., Zhu, Meiling, Simpson, Christine, Dhodapkar, Madhav, Insogna, Karl L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bone bone resorption Bone Resorption - genetics Bone Resorption - pathology CD36 CD36 Antigens - chemistry CD36 Antigens - genetics CD47 CD47 Antigen - chemistry CD47 Antigen - genetics Cell Biology Female Hypercalcemia - genetics Hypercalcemia - pathology Membrane Proteins - chemistry Membrane Proteins - genetics Mice Mice, Knockout NG-Nitroarginine Methyl Ester - administration & dosage Nitric Oxide - biosynthesis Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - chemistry osteoblast osteoclast Osteoclasts - chemistry Osteoclasts - drug effects Osteoclasts - metabolism osteocyte Osteogenesis - genetics osteoporosis parathyroid hormone Parathyroid Hormone - chemistry Parathyroid Hormone - genetics Signal Detection, Psychological Signal Transduction - drug effects thrombospondin Thrombospondin 1 - chemistry Thrombospondin 1 - genetics TSP-1
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