Long‐term safety outcome of systemic immunosuppression in pig‐to‐nonhuman primate corneal xenotransplantation

Background Safety concerns exist for corneal recipients under immunosuppression. We report long‐term safety results of porcine corneal xenotransplantation under immunosuppression in nonhuman primates. Methods Systemic monitoring data from 49 Chinese rhesus macaques that received pig corneal transpla...

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Veröffentlicht in:	Xenotransplantation (Københaven) 2018-07, Vol.25 (4), p.e12442-n/a
Hauptverfasser:	Choi, Se Hyun, Yoon, Chang Ho, Lee, Hyun Ju, Kim, Hong Pyo, Kim, Jong Min, Che, Jeong‐Hwan, Roh, Kyoung Min, Choi, Hyuk Jin, Kim, Jiyeon, Hwang, Eung Soo, Park, Chung‐Gyu, Kim, Mee Kum
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD20 antigen CD40 antigen CD40L protein Chicken pox Cornea Corneal transplantation Corneal Transplantation - methods Cytomegalovirus Deoxyribonucleic acid DNA Electrolytes Graft Rejection - immunology Graft Rejection - prevention & control Graft Survival - immunology Heterografts - drug effects Humans Immune Tolerance - drug effects Immunocompromised hosts Immunosuppression Immunosuppression Therapy - methods Immunosuppressive agents Immunosuppressive Agents - pharmacology infection Islets of Langerhans Transplantation - methods Liver Macaca mulatta - immunology Monoclonal antibodies nonhuman primates Outbreaks Primates Prophylaxis rhesus cytomegalovirus Safety simian varicella virus Swine Tacrolimus Tacrolimus - therapeutic use Thrombotic microangiopathy Time Transplantation, Heterologous - methods Varicella Xenografts xenotransplantation
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