COX-2 Expression in Breast Carcinoma with Correlation to Clinicopathological Parameters
Objective: Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma deaths in women. Its etiology is multifactorial, implicating reproductive factors, hormonal imbalances and genetic predispositions. Studies have shown that Cycloxygenase-2 (COX-2) plays an important rol...
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| Veröffentlicht in: | Asian Pacific journal of cancer prevention : APJCP 2018-07, Vol.19 (7), p.1971-1975 |
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| container_end_page | 1975 |
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| container_issue | 7 |
| container_start_page | 1971 |
| container_title | Asian Pacific journal of cancer prevention : APJCP |
| container_volume | 19 |
| creator | Solanki, Ranjana Agrawal, Natasha Ansari, Maryam Jain, Shashank Jindal, Arpita |
| description | Objective: Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma deaths in
women. Its etiology is multifactorial, implicating reproductive factors, hormonal imbalances and genetic predispositions.
Studies have shown that Cycloxygenase-2 (COX-2) plays an important role in the carcinogenesis and increased expression
has been regarded as a poor prognostic factor. The objective of our study is 1. To study COX-2 expression in normal
breast tissue, DCIS and invasive breast cancer. 2. To determine COX-2 expression with clinicopathological prognostic
parameters. Methods: Radical mastectomy specimens were studied for COX-2 expression by immunohistochemistry
in 50 patients diagnosed as breast carcinoma. COX-2 expression is quantified as IHS Score and separately calculated
for normal breast epithelium near the tumor, DCIS and invasive areas. Relationship between COX-2 expression with
various clinicopathological parameters was evaluated. Result: The results of our study suggest an association of the
expression of COX-2 to the factors associated with poor prognosis in breast cancer, such as larger tumor size, positive
lymph node status, higher T stage and N stage and lymphovascular invasion. There was a higher COX-2 expression
in the DCIS component as compared to the invasive ductal carcinoma component and the adjoining breast epithelium.
Conclusion: Our study established the role of COX-2 in carcinogenesis and its association with adverse prognostic
factors. |
| doi_str_mv | 10.22034/APJCP.2018.19.7.1971 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6165637</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>30051683</sourcerecordid><originalsourceid>FETCH-LOGICAL-p148t-e6f8e515e68339459563c3cf4f790762ef5105ea21e3445ca7b29d52cbd273763</originalsourceid><addsrcrecordid>eNpVkMtOwzAQRS0EoqXwCSD_QILfTjZIxSovVWoXILqLXNdpjZI4ss3r7wniIdjcWcydMzMXgFOMckIQZefT5Z1a5gThIsdlLgeReA-MCZMik4Ks9sEYc0wzSUUxAkcxPiHEeCH5IRhRhDgWBR2DR7VYZQTO3vpgY3S-g66Dl8HqmKDSwbjOtxq-urSDyodgG50-TclD1bjOGd_rtPON3zqjG7jUQbc22RCPwUGtm2hPvusEPFzN7tVNNl9c36rpPOsxK1JmRV1YjrkdjqEl4yUX1FBTs1qWaPjC1hwjbjXBljLGjZZrUm44MesNkVQKOgEXX9z-ed3ajbFdCrqp-uBaHd4rr131v9O5XbX1L5XAYtglB8DZX8Dv5E9E9AOwHGtw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>COX-2 Expression in Breast Carcinoma with Correlation to Clinicopathological Parameters</title><source>MEDLINE</source><source>PubMed Central（OA）</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Open Access: Freely Accessible Journals by multiple vendors</source><source>Directory of Open Access Journals</source><creator>Solanki, Ranjana ; Agrawal, Natasha ; Ansari, Maryam ; Jain, Shashank ; Jindal, Arpita</creator><creatorcontrib>Solanki, Ranjana ; Agrawal, Natasha ; Ansari, Maryam ; Jain, Shashank ; Jindal, Arpita</creatorcontrib><description>Objective: Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma deaths in
women. Its etiology is multifactorial, implicating reproductive factors, hormonal imbalances and genetic predispositions.
Studies have shown that Cycloxygenase-2 (COX-2) plays an important role in the carcinogenesis and increased expression
has been regarded as a poor prognostic factor. The objective of our study is 1. To study COX-2 expression in normal
breast tissue, DCIS and invasive breast cancer. 2. To determine COX-2 expression with clinicopathological prognostic
parameters. Methods: Radical mastectomy specimens were studied for COX-2 expression by immunohistochemistry
in 50 patients diagnosed as breast carcinoma. COX-2 expression is quantified as IHS Score and separately calculated
for normal breast epithelium near the tumor, DCIS and invasive areas. Relationship between COX-2 expression with
various clinicopathological parameters was evaluated. Result: The results of our study suggest an association of the
expression of COX-2 to the factors associated with poor prognosis in breast cancer, such as larger tumor size, positive
lymph node status, higher T stage and N stage and lymphovascular invasion. There was a higher COX-2 expression
in the DCIS component as compared to the invasive ductal carcinoma component and the adjoining breast epithelium.
Conclusion: Our study established the role of COX-2 in carcinogenesis and its association with adverse prognostic
factors.</description><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><identifier>DOI: 10.22034/APJCP.2018.19.7.1971</identifier><identifier>PMID: 30051683</identifier><language>eng</language><publisher>Thailand: West Asia Organization for Cancer Prevention</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - metabolism ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Intraductal, Noninfiltrating - metabolism ; Carcinoma, Intraductal, Noninfiltrating - pathology ; Cyclooxygenase 2 - metabolism ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Prognosis</subject><ispartof>Asian Pacific journal of cancer prevention : APJCP, 2018-07, Vol.19 (7), p.1971-1975</ispartof><rights>Creative Commons Attribution License</rights><rights>Copyright: © Asian Pacific Journal of Cancer Prevention 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165637/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165637/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30051683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Solanki, Ranjana</creatorcontrib><creatorcontrib>Agrawal, Natasha</creatorcontrib><creatorcontrib>Ansari, Maryam</creatorcontrib><creatorcontrib>Jain, Shashank</creatorcontrib><creatorcontrib>Jindal, Arpita</creatorcontrib><title>COX-2 Expression in Breast Carcinoma with Correlation to Clinicopathological Parameters</title><title>Asian Pacific journal of cancer prevention : APJCP</title><addtitle>Asian Pac J Cancer Prev</addtitle><description>Objective: Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma deaths in
women. Its etiology is multifactorial, implicating reproductive factors, hormonal imbalances and genetic predispositions.
Studies have shown that Cycloxygenase-2 (COX-2) plays an important role in the carcinogenesis and increased expression
has been regarded as a poor prognostic factor. The objective of our study is 1. To study COX-2 expression in normal
breast tissue, DCIS and invasive breast cancer. 2. To determine COX-2 expression with clinicopathological prognostic
parameters. Methods: Radical mastectomy specimens were studied for COX-2 expression by immunohistochemistry
in 50 patients diagnosed as breast carcinoma. COX-2 expression is quantified as IHS Score and separately calculated
for normal breast epithelium near the tumor, DCIS and invasive areas. Relationship between COX-2 expression with
various clinicopathological parameters was evaluated. Result: The results of our study suggest an association of the
expression of COX-2 to the factors associated with poor prognosis in breast cancer, such as larger tumor size, positive
lymph node status, higher T stage and N stage and lymphovascular invasion. There was a higher COX-2 expression
in the DCIS component as compared to the invasive ductal carcinoma component and the adjoining breast epithelium.
Conclusion: Our study established the role of COX-2 in carcinogenesis and its association with adverse prognostic
factors.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - metabolism</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Intraductal, Noninfiltrating - metabolism</subject><subject>Carcinoma, Intraductal, Noninfiltrating - pathology</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Prognosis</subject><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtOwzAQRS0EoqXwCSD_QILfTjZIxSovVWoXILqLXNdpjZI4ss3r7wniIdjcWcydMzMXgFOMckIQZefT5Z1a5gThIsdlLgeReA-MCZMik4Ks9sEYc0wzSUUxAkcxPiHEeCH5IRhRhDgWBR2DR7VYZQTO3vpgY3S-g66Dl8HqmKDSwbjOtxq-urSDyodgG50-TclD1bjOGd_rtPON3zqjG7jUQbc22RCPwUGtm2hPvusEPFzN7tVNNl9c36rpPOsxK1JmRV1YjrkdjqEl4yUX1FBTs1qWaPjC1hwjbjXBljLGjZZrUm44MesNkVQKOgEXX9z-ed3ajbFdCrqp-uBaHd4rr131v9O5XbX1L5XAYtglB8DZX8Dv5E9E9AOwHGtw</recordid><startdate>20180727</startdate><enddate>20180727</enddate><creator>Solanki, Ranjana</creator><creator>Agrawal, Natasha</creator><creator>Ansari, Maryam</creator><creator>Jain, Shashank</creator><creator>Jindal, Arpita</creator><general>West Asia Organization for Cancer Prevention</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>20180727</creationdate><title>COX-2 Expression in Breast Carcinoma with Correlation to Clinicopathological Parameters</title><author>Solanki, Ranjana ; Agrawal, Natasha ; Ansari, Maryam ; Jain, Shashank ; Jindal, Arpita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p148t-e6f8e515e68339459563c3cf4f790762ef5105ea21e3445ca7b29d52cbd273763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma, Ductal, Breast - metabolism</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Intraductal, Noninfiltrating - metabolism</topic><topic>Carcinoma, Intraductal, Noninfiltrating - pathology</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solanki, Ranjana</creatorcontrib><creatorcontrib>Agrawal, Natasha</creatorcontrib><creatorcontrib>Ansari, Maryam</creatorcontrib><creatorcontrib>Jain, Shashank</creatorcontrib><creatorcontrib>Jindal, Arpita</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian Pacific journal of cancer prevention : APJCP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solanki, Ranjana</au><au>Agrawal, Natasha</au><au>Ansari, Maryam</au><au>Jain, Shashank</au><au>Jindal, Arpita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COX-2 Expression in Breast Carcinoma with Correlation to Clinicopathological Parameters</atitle><jtitle>Asian Pacific journal of cancer prevention : APJCP</jtitle><addtitle>Asian Pac J Cancer Prev</addtitle><date>2018-07-27</date><risdate>2018</risdate><volume>19</volume><issue>7</issue><spage>1971</spage><epage>1975</epage><pages>1971-1975</pages><issn>1513-7368</issn><eissn>2476-762X</eissn><abstract>Objective: Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma deaths in
women. Its etiology is multifactorial, implicating reproductive factors, hormonal imbalances and genetic predispositions.
Studies have shown that Cycloxygenase-2 (COX-2) plays an important role in the carcinogenesis and increased expression
has been regarded as a poor prognostic factor. The objective of our study is 1. To study COX-2 expression in normal
breast tissue, DCIS and invasive breast cancer. 2. To determine COX-2 expression with clinicopathological prognostic
parameters. Methods: Radical mastectomy specimens were studied for COX-2 expression by immunohistochemistry
in 50 patients diagnosed as breast carcinoma. COX-2 expression is quantified as IHS Score and separately calculated
for normal breast epithelium near the tumor, DCIS and invasive areas. Relationship between COX-2 expression with
various clinicopathological parameters was evaluated. Result: The results of our study suggest an association of the
expression of COX-2 to the factors associated with poor prognosis in breast cancer, such as larger tumor size, positive
lymph node status, higher T stage and N stage and lymphovascular invasion. There was a higher COX-2 expression
in the DCIS component as compared to the invasive ductal carcinoma component and the adjoining breast epithelium.
Conclusion: Our study established the role of COX-2 in carcinogenesis and its association with adverse prognostic
factors.</abstract><cop>Thailand</cop><pub>West Asia Organization for Cancer Prevention</pub><pmid>30051683</pmid><doi>10.22034/APJCP.2018.19.7.1971</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central（OA）; EZB-FREE-00999 freely available EZB journals; Open Access: Freely Accessible Journals by multiple vendors; Directory of Open Access Journals |
| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Carcinoma, Intraductal, Noninfiltrating - metabolism Carcinoma, Intraductal, Noninfiltrating - pathology Cyclooxygenase 2 - metabolism Female Follow-Up Studies Humans Middle Aged Prognosis |
| title | COX-2 Expression in Breast Carcinoma with Correlation to Clinicopathological Parameters |
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