Metabolaid ® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation
Lemon verbena ( ) has been used as a food spice, cosmetic, and in traditional medicine formulations to treat asthma and diabetes in South America and Southern Europe. Hibiscus flower ( L.) is used in traditional Chinese medicine in the form of a tea to treat hypertension and inflammation. In the pre...
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| Veröffentlicht in: | Nutrients 2018-09, Vol.10 (9), p.1204 |
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| creator | Lee, Young-Sil Yang, Won-Kyung Kim, Hwa Yeon Min, Bokkee Caturla, Nuria Jones, Jonathan Park, Yang-Chun Lee, Young-Cheol Kim, Seung-Hyung |
| description | Lemon verbena (
) has been used as a food spice, cosmetic, and in traditional medicine formulations to treat asthma and diabetes in South America and Southern Europe. Hibiscus flower (
L.) is used in traditional Chinese medicine in the form of a tea to treat hypertension and inflammation. In the present study, we examined the synergistic effects of a formula of Metabolaid
(MetA), a combination of lemon verbena and hibiscus-flower extracts, on obesity and its complications in high-fat-diet (HFD)-induced obese mice. The results showed that MetA decreased body weight, white adipose tissue (WAT), and liver weight. Additionally, serum and hepatic lipid profiles, glucose levels, glucose tolerance, and cold-induced thermogenesis were significantly improved. Appetite-regulating hormones adiponectin and leptin were significantly increased and decreased, respectively, while the inflammatory-related factors tumor necrosis factor (TNF)-α and interleukin (IL)-6 were downregulated by MetA. Adipogenesis-activating gene expression was decreased, while increased thermogenesis-inducing genes were upregulated in the WAT, correlating with increased phosphorylation of AMPK and fatty-acid oxidation in the liver. Taken together, these results suggest that MetA decreased obesity and its complications in HFD mice. Therefore, this formula may be a candidate for the prevention and treatment of obesity and its complications. |
| doi_str_mv | 10.3390/nu10091204 |
| format | Article |
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) has been used as a food spice, cosmetic, and in traditional medicine formulations to treat asthma and diabetes in South America and Southern Europe. Hibiscus flower (
L.) is used in traditional Chinese medicine in the form of a tea to treat hypertension and inflammation. In the present study, we examined the synergistic effects of a formula of Metabolaid
(MetA), a combination of lemon verbena and hibiscus-flower extracts, on obesity and its complications in high-fat-diet (HFD)-induced obese mice. The results showed that MetA decreased body weight, white adipose tissue (WAT), and liver weight. Additionally, serum and hepatic lipid profiles, glucose levels, glucose tolerance, and cold-induced thermogenesis were significantly improved. Appetite-regulating hormones adiponectin and leptin were significantly increased and decreased, respectively, while the inflammatory-related factors tumor necrosis factor (TNF)-α and interleukin (IL)-6 were downregulated by MetA. Adipogenesis-activating gene expression was decreased, while increased thermogenesis-inducing genes were upregulated in the WAT, correlating with increased phosphorylation of AMPK and fatty-acid oxidation in the liver. Taken together, these results suggest that MetA decreased obesity and its complications in HFD mice. Therefore, this formula may be a candidate for the prevention and treatment of obesity and its complications.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu10091204</identifier><identifier>PMID: 30200432</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adipogenesis ; Adiponectin ; Adipose tissue ; Adipose Tissue, White - drug effects ; Adipose Tissue, White - physiopathology ; Adiposity - drug effects ; Aloysia citrodora ; AMP-activated protein kinase ; AMP-Activated Protein Kinases - metabolism ; animal disease models ; Animals ; Anti-Obesity Agents - isolation & purification ; Anti-Obesity Agents - pharmacology ; Antioxidants ; asthma ; beta oxidation ; Biomarkers - blood ; blood serum ; Body weight ; Cold tolerance ; Complications ; Diabetes ; Diabetes mellitus ; Diet ; Diet, High-Fat ; Disease Models, Animal ; Drug dosages ; Enzyme Activation ; Enzyme Activators - isolation & purification ; Enzyme Activators - pharmacology ; flower extracts ; Flowers ; Food ; Formulations ; Gene expression ; gene expression regulation ; genes ; Glucose ; Glucose tolerance ; heat production ; Herbal medicine ; Hibiscus - chemistry ; Hibiscus sabdariffa ; High fat diet ; Hormones ; Humidity ; Hypertension ; Inflammation ; interleukin-6 ; Kinases ; Laboratory animals ; Leptin ; lipid composition ; Lipids ; Lippia - chemistry ; Lippia citriodora ; Liver ; Male ; Medicine ; Metabolism ; Mice ; Mice, Inbred C57BL ; Obesity ; Obesity - blood ; Obesity - enzymology ; Obesity - physiopathology ; Obesity - prevention & control ; Oriental traditional medicine ; Oxidation ; Oxidative stress ; Phosphorylation ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Leaves ; Polyphenols ; Proteins ; Rodents ; Signal Transduction - drug effects ; South America ; Southern European region ; spices ; synergism ; Synergistic effect ; Tea ; Thermogenesis ; Thermogenesis - drug effects ; tumor necrosis factor-alpha ; Tumor necrosis factor-α ; Verbena - chemistry ; Weight Gain - drug effects ; white adipose tissue</subject><ispartof>Nutrients, 2018-09, Vol.10 (9), p.1204</ispartof><rights>2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-7594bd7d4d64ca8ec1897673df6644fd6351c6b46b8ea41af80bbad56844077e3</citedby><cites>FETCH-LOGICAL-c505t-7594bd7d4d64ca8ec1897673df6644fd6351c6b46b8ea41af80bbad56844077e3</cites><orcidid>0000-0002-4598-1733 ; 0000-0001-9420-2305 ; 0000-0002-5645-869X ; 0000-0002-6896-1778</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165361/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165361/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30200432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Young-Sil</creatorcontrib><creatorcontrib>Yang, Won-Kyung</creatorcontrib><creatorcontrib>Kim, Hwa Yeon</creatorcontrib><creatorcontrib>Min, Bokkee</creatorcontrib><creatorcontrib>Caturla, Nuria</creatorcontrib><creatorcontrib>Jones, Jonathan</creatorcontrib><creatorcontrib>Park, Yang-Chun</creatorcontrib><creatorcontrib>Lee, Young-Cheol</creatorcontrib><creatorcontrib>Kim, Seung-Hyung</creatorcontrib><title>Metabolaid ® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Lemon verbena (
) has been used as a food spice, cosmetic, and in traditional medicine formulations to treat asthma and diabetes in South America and Southern Europe. Hibiscus flower (
L.) is used in traditional Chinese medicine in the form of a tea to treat hypertension and inflammation. In the present study, we examined the synergistic effects of a formula of Metabolaid
(MetA), a combination of lemon verbena and hibiscus-flower extracts, on obesity and its complications in high-fat-diet (HFD)-induced obese mice. The results showed that MetA decreased body weight, white adipose tissue (WAT), and liver weight. Additionally, serum and hepatic lipid profiles, glucose levels, glucose tolerance, and cold-induced thermogenesis were significantly improved. Appetite-regulating hormones adiponectin and leptin were significantly increased and decreased, respectively, while the inflammatory-related factors tumor necrosis factor (TNF)-α and interleukin (IL)-6 were downregulated by MetA. Adipogenesis-activating gene expression was decreased, while increased thermogenesis-inducing genes were upregulated in the WAT, correlating with increased phosphorylation of AMPK and fatty-acid oxidation in the liver. Taken together, these results suggest that MetA decreased obesity and its complications in HFD mice. Therefore, this formula may be a candidate for the prevention and treatment of obesity and its complications.</description><subject>Adipogenesis</subject><subject>Adiponectin</subject><subject>Adipose tissue</subject><subject>Adipose Tissue, White - drug effects</subject><subject>Adipose Tissue, White - physiopathology</subject><subject>Adiposity - drug effects</subject><subject>Aloysia citrodora</subject><subject>AMP-activated protein kinase</subject><subject>AMP-Activated Protein Kinases - metabolism</subject><subject>animal disease models</subject><subject>Animals</subject><subject>Anti-Obesity Agents - isolation & purification</subject><subject>Anti-Obesity Agents - pharmacology</subject><subject>Antioxidants</subject><subject>asthma</subject><subject>beta oxidation</subject><subject>Biomarkers - blood</subject><subject>blood serum</subject><subject>Body weight</subject><subject>Cold tolerance</subject><subject>Complications</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diet</subject><subject>Diet, High-Fat</subject><subject>Disease Models, Animal</subject><subject>Drug dosages</subject><subject>Enzyme Activation</subject><subject>Enzyme Activators - isolation & purification</subject><subject>Enzyme Activators - pharmacology</subject><subject>flower extracts</subject><subject>Flowers</subject><subject>Food</subject><subject>Formulations</subject><subject>Gene expression</subject><subject>gene expression regulation</subject><subject>genes</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>heat production</subject><subject>Herbal medicine</subject><subject>Hibiscus - chemistry</subject><subject>Hibiscus sabdariffa</subject><subject>High fat diet</subject><subject>Hormones</subject><subject>Humidity</subject><subject>Hypertension</subject><subject>Inflammation</subject><subject>interleukin-6</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Leptin</subject><subject>lipid composition</subject><subject>Lipids</subject><subject>Lippia - chemistry</subject><subject>Lippia citriodora</subject><subject>Liver</subject><subject>Male</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - enzymology</subject><subject>Obesity - physiopathology</subject><subject>Obesity - prevention & control</subject><subject>Oriental traditional medicine</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Phosphorylation</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves</subject><subject>Polyphenols</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Signal Transduction - drug effects</subject><subject>South America</subject><subject>Southern European region</subject><subject>spices</subject><subject>synergism</subject><subject>Synergistic effect</subject><subject>Tea</subject><subject>Thermogenesis</subject><subject>Thermogenesis - drug effects</subject><subject>tumor necrosis factor-alpha</subject><subject>Tumor necrosis factor-α</subject><subject>Verbena - chemistry</subject><subject>Weight Gain - drug effects</subject><subject>white adipose tissue</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk1uFDEQhVsIRKKQDQdAltggpAb_td2zQRoNGRIxUWYBbFv-qZ5x1G0H2z2Qw3AFDsHJcMgQAhu8qZLep-d6paqqpwS_YmyGX_uJYDwjFPMH1SHFktZCcPbwXn9QHad0iW-exFKwx9UBwxRjzuhh9e0cstJhUM6iH9_RIozaeZVd8Cj0aAVjaT5B1OAVUt6iU6ddMlNCyyF8gYhOvuaoTEbrCDvwORVgs62XKqO3DnJ95u1kwKILDcnla5S3MUybLZqfr-u5yW6nclHXMWRwHr0vXydAe6HM8KR61KshwfG-HlUflycfFqf16uLd2WK-qk2Dm1zLZsa1lZZbwY1qwZB2JoVkti_5eW8Fa4gRmgvdguJE9S3WWtlGtJxjKYEdVW9ufa8mPYI1JUlUQ3cV3ajidReU6_5WvNt2m7DrBBENE6QYvNgbxPB5gpS7sawJhkF5CFPqKG3FjPKG0P-jBFPGKGvagj7_B70MU_RlE4VqacOk-EW9vKVMDClF6O_mJri7uZHuz40U-Nn9pHfo74tgPwFS87ic</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Lee, Young-Sil</creator><creator>Yang, Won-Kyung</creator><creator>Kim, Hwa Yeon</creator><creator>Min, Bokkee</creator><creator>Caturla, Nuria</creator><creator>Jones, Jonathan</creator><creator>Park, Yang-Chun</creator><creator>Lee, Young-Cheol</creator><creator>Kim, Seung-Hyung</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4598-1733</orcidid><orcidid>https://orcid.org/0000-0001-9420-2305</orcidid><orcidid>https://orcid.org/0000-0002-5645-869X</orcidid><orcidid>https://orcid.org/0000-0002-6896-1778</orcidid></search><sort><creationdate>20180901</creationdate><title>Metabolaid ® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation</title><author>Lee, Young-Sil ; Yang, Won-Kyung ; Kim, Hwa Yeon ; Min, Bokkee ; Caturla, Nuria ; Jones, Jonathan ; Park, Yang-Chun ; Lee, Young-Cheol ; Kim, Seung-Hyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-7594bd7d4d64ca8ec1897673df6644fd6351c6b46b8ea41af80bbad56844077e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipogenesis</topic><topic>Adiponectin</topic><topic>Adipose tissue</topic><topic>Adipose Tissue, White - drug effects</topic><topic>Adipose Tissue, White - physiopathology</topic><topic>Adiposity - drug effects</topic><topic>Aloysia citrodora</topic><topic>AMP-activated protein kinase</topic><topic>AMP-Activated Protein Kinases - metabolism</topic><topic>animal disease models</topic><topic>Animals</topic><topic>Anti-Obesity Agents - isolation & purification</topic><topic>Anti-Obesity Agents - pharmacology</topic><topic>Antioxidants</topic><topic>asthma</topic><topic>beta oxidation</topic><topic>Biomarkers - blood</topic><topic>blood serum</topic><topic>Body weight</topic><topic>Cold tolerance</topic><topic>Complications</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diet</topic><topic>Diet, High-Fat</topic><topic>Disease Models, Animal</topic><topic>Drug dosages</topic><topic>Enzyme Activation</topic><topic>Enzyme Activators - isolation & purification</topic><topic>Enzyme Activators - pharmacology</topic><topic>flower extracts</topic><topic>Flowers</topic><topic>Food</topic><topic>Formulations</topic><topic>Gene expression</topic><topic>gene expression regulation</topic><topic>genes</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>heat production</topic><topic>Herbal medicine</topic><topic>Hibiscus - chemistry</topic><topic>Hibiscus sabdariffa</topic><topic>High fat diet</topic><topic>Hormones</topic><topic>Humidity</topic><topic>Hypertension</topic><topic>Inflammation</topic><topic>interleukin-6</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Leptin</topic><topic>lipid composition</topic><topic>Lipids</topic><topic>Lippia - chemistry</topic><topic>Lippia citriodora</topic><topic>Liver</topic><topic>Male</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - enzymology</topic><topic>Obesity - physiopathology</topic><topic>Obesity - prevention & control</topic><topic>Oriental traditional medicine</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Phosphorylation</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves</topic><topic>Polyphenols</topic><topic>Proteins</topic><topic>Rodents</topic><topic>Signal Transduction - drug effects</topic><topic>South America</topic><topic>Southern European region</topic><topic>spices</topic><topic>synergism</topic><topic>Synergistic effect</topic><topic>Tea</topic><topic>Thermogenesis</topic><topic>Thermogenesis - drug effects</topic><topic>tumor necrosis factor-alpha</topic><topic>Tumor necrosis factor-α</topic><topic>Verbena - chemistry</topic><topic>Weight Gain - drug effects</topic><topic>white adipose tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Young-Sil</creatorcontrib><creatorcontrib>Yang, Won-Kyung</creatorcontrib><creatorcontrib>Kim, Hwa Yeon</creatorcontrib><creatorcontrib>Min, Bokkee</creatorcontrib><creatorcontrib>Caturla, Nuria</creatorcontrib><creatorcontrib>Jones, Jonathan</creatorcontrib><creatorcontrib>Park, Yang-Chun</creatorcontrib><creatorcontrib>Lee, Young-Cheol</creatorcontrib><creatorcontrib>Kim, Seung-Hyung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Young-Sil</au><au>Yang, Won-Kyung</au><au>Kim, Hwa Yeon</au><au>Min, Bokkee</au><au>Caturla, Nuria</au><au>Jones, Jonathan</au><au>Park, Yang-Chun</au><au>Lee, Young-Cheol</au><au>Kim, Seung-Hyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolaid ® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>10</volume><issue>9</issue><spage>1204</spage><pages>1204-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Lemon verbena (
) has been used as a food spice, cosmetic, and in traditional medicine formulations to treat asthma and diabetes in South America and Southern Europe. Hibiscus flower (
L.) is used in traditional Chinese medicine in the form of a tea to treat hypertension and inflammation. In the present study, we examined the synergistic effects of a formula of Metabolaid
(MetA), a combination of lemon verbena and hibiscus-flower extracts, on obesity and its complications in high-fat-diet (HFD)-induced obese mice. The results showed that MetA decreased body weight, white adipose tissue (WAT), and liver weight. Additionally, serum and hepatic lipid profiles, glucose levels, glucose tolerance, and cold-induced thermogenesis were significantly improved. Appetite-regulating hormones adiponectin and leptin were significantly increased and decreased, respectively, while the inflammatory-related factors tumor necrosis factor (TNF)-α and interleukin (IL)-6 were downregulated by MetA. Adipogenesis-activating gene expression was decreased, while increased thermogenesis-inducing genes were upregulated in the WAT, correlating with increased phosphorylation of AMPK and fatty-acid oxidation in the liver. Taken together, these results suggest that MetA decreased obesity and its complications in HFD mice. Therefore, this formula may be a candidate for the prevention and treatment of obesity and its complications.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30200432</pmid><doi>10.3390/nu10091204</doi><orcidid>https://orcid.org/0000-0002-4598-1733</orcidid><orcidid>https://orcid.org/0000-0001-9420-2305</orcidid><orcidid>https://orcid.org/0000-0002-5645-869X</orcidid><orcidid>https://orcid.org/0000-0002-6896-1778</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6643 |
| ispartof | Nutrients, 2018-09, Vol.10 (9), p.1204 |
| issn | 2072-6643 2072-6643 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6165361 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Adipogenesis Adiponectin Adipose tissue Adipose Tissue, White - drug effects Adipose Tissue, White - physiopathology Adiposity - drug effects Aloysia citrodora AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism animal disease models Animals Anti-Obesity Agents - isolation & purification Anti-Obesity Agents - pharmacology Antioxidants asthma beta oxidation Biomarkers - blood blood serum Body weight Cold tolerance Complications Diabetes Diabetes mellitus Diet Diet, High-Fat Disease Models, Animal Drug dosages Enzyme Activation Enzyme Activators - isolation & purification Enzyme Activators - pharmacology flower extracts Flowers Food Formulations Gene expression gene expression regulation genes Glucose Glucose tolerance heat production Herbal medicine Hibiscus - chemistry Hibiscus sabdariffa High fat diet Hormones Humidity Hypertension Inflammation interleukin-6 Kinases Laboratory animals Leptin lipid composition Lipids Lippia - chemistry Lippia citriodora Liver Male Medicine Metabolism Mice Mice, Inbred C57BL Obesity Obesity - blood Obesity - enzymology Obesity - physiopathology Obesity - prevention & control Oriental traditional medicine Oxidation Oxidative stress Phosphorylation Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves Polyphenols Proteins Rodents Signal Transduction - drug effects South America Southern European region spices synergism Synergistic effect Tea Thermogenesis Thermogenesis - drug effects tumor necrosis factor-alpha Tumor necrosis factor-α Verbena - chemistry Weight Gain - drug effects white adipose tissue |
| title | Metabolaid ® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T18%3A48%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabolaid%20%C2%AE%20Combination%20of%20Lemon%20Verbena%20and%20Hibiscus%20Flower%20Extract%20Prevents%20High-Fat%20Diet-Induced%20Obesity%20through%20AMP-Activated%20Protein%20Kinase%20Activation&rft.jtitle=Nutrients&rft.au=Lee,%20Young-Sil&rft.date=2018-09-01&rft.volume=10&rft.issue=9&rft.spage=1204&rft.pages=1204-&rft.issn=2072-6643&rft.eissn=2072-6643&rft_id=info:doi/10.3390/nu10091204&rft_dat=%3Cproquest_pubme%3E2286924512%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2182537658&rft_id=info:pmid/30200432&rfr_iscdi=true |