Non-Antibiotic Antimicrobial Catheter Lock Solutions in Patients on Home Parenteral Nutrition
Patients on home parenteral nutrition (HPN) are dependent on central venous access for long-term sustenance, and catheter-related bloodstream infections (CRBSIs) are a major cause of morbidity and mortality in this patient population. As such, there is much interest in finding new methods for preven...
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| Veröffentlicht in: | Nutrients 2018-08, Vol.10 (9), p.1165 |
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| description | Patients on home parenteral nutrition (HPN) are dependent on central venous access for long-term sustenance, and catheter-related bloodstream infections (CRBSIs) are a major cause of morbidity and mortality in this patient population. As such, there is much interest in finding new methods for preventing CRBSIs in patients on HPN. As it is thought that these infections are preceded by microbial colonization of the catheter, one approach is to use antimicrobial catheter lock solutions. Although antibiotic catheter lock solutions have been present for decades, their use has been mostly limited to the treatment of CRBSIs due to concern for promoting microbial resistance. Recently, however, with the advent of non-antibiotic antimicrobial catheter lock solutions, this approach is gaining popularity as a promising method to decrease rates of CRBSI in HPN patients. |
| doi_str_mv | 10.3390/nu10091165 |
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As such, there is much interest in finding new methods for preventing CRBSIs in patients on HPN. As it is thought that these infections are preceded by microbial colonization of the catheter, one approach is to use antimicrobial catheter lock solutions. Although antibiotic catheter lock solutions have been present for decades, their use has been mostly limited to the treatment of CRBSIs due to concern for promoting microbial resistance. Recently, however, with the advent of non-antibiotic antimicrobial catheter lock solutions, this approach is gaining popularity as a promising method to decrease rates of CRBSI in HPN patients.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu10091165</identifier><identifier>PMID: 30149607</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adults ; Anti-Bacterial Agents - therapeutic use ; Anti-Infective Agents - adverse effects ; Anti-Infective Agents - therapeutic use ; Antibiotics ; Anticoagulants ; Antiinfectives and antibacterials ; Antimicrobial agents ; Biofilms ; blood flow ; Catheter-Related Infections - diagnosis ; Catheter-Related Infections - microbiology ; Catheter-Related Infections - prevention & control ; Catheterization, Central Venous - adverse effects ; Catheterization, Central Venous - instrumentation ; Catheters ; Catheters, Indwelling - adverse effects ; Central Venous Catheters - adverse effects ; Clinical trials ; Colonization ; Drug Resistance, Bacterial ; Ethanol ; Gastroenterology ; Hemodialysis ; Humans ; Infections ; Medical instruments ; methodology ; microbial colonization ; Microorganisms ; Morbidity ; mortality ; Nutrition ; parenteral feeding ; Parenteral nutrition ; Parenteral Nutrition, Home - adverse effects ; Parenteral Nutrition, Home - instrumentation ; Patients ; Prevention ; Protective Factors ; Review ; Risk Factors ; Systematic review ; Treatment Outcome</subject><ispartof>Nutrients, 2018-08, Vol.10 (9), p.1165</ispartof><rights>2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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adverse effects</subject><subject>Central Venous Catheters - adverse effects</subject><subject>Clinical trials</subject><subject>Colonization</subject><subject>Drug Resistance, Bacterial</subject><subject>Ethanol</subject><subject>Gastroenterology</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Infections</subject><subject>Medical instruments</subject><subject>methodology</subject><subject>microbial colonization</subject><subject>Microorganisms</subject><subject>Morbidity</subject><subject>mortality</subject><subject>Nutrition</subject><subject>parenteral feeding</subject><subject>Parenteral nutrition</subject><subject>Parenteral Nutrition, Home - adverse effects</subject><subject>Parenteral Nutrition, Home - instrumentation</subject><subject>Patients</subject><subject>Prevention</subject><subject>Protective Factors</subject><subject>Review</subject><subject>Risk Factors</subject><subject>Systematic review</subject><subject>Treatment Outcome</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU9LHTEUxUNRqujb-AHKgBsRpt78ncmmIA9bCw8V1KWEzEymRmcSTTJCv30zfVatK7PJTfK7h5NzEdrD8JVSCUduwgASY8E_oW0CFSmFYHTjTb2FFjHewbwqqAT9jLYoYCYFVNvo5sy78tgl21ifbFvM5Wjb4Burh2Kp061JJhQr394Xl36YkvUuFtYVFzpZ41IsvCtO_WjyRchnE3Lb2ZSCncldtNnrIZrF876Drr-fXC1Py9X5j5_L41XZcuCp7IjpOl4z3EgwdW161uCKCYGbTveckkb2hkidPQOXhrAGaknnmmsQnBO6g76tdR-mZjRdm41kH-oh2FGH38prq_5_cfZW_fJPSuTccI2zwMGzQPCPk4lJjTa2Zhi0M36KipBaSAKcfwAFmS0xxkRG99-hd34KLiehCK4JpxX8FTxcUzn1GIPpX3xjUPOM1euMM_zl7U9f0H8TpX8ABNigww</recordid><startdate>20180825</startdate><enddate>20180825</enddate><creator>Noelting, Jessica</creator><creator>Jurewitsch, Brian</creator><creator>Allard, Johane P</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5826-6229</orcidid><orcidid>https://orcid.org/0000-0002-8956-7059</orcidid></search><sort><creationdate>20180825</creationdate><title>Non-Antibiotic Antimicrobial Catheter Lock Solutions in Patients on Home Parenteral Nutrition</title><author>Noelting, Jessica ; Jurewitsch, Brian ; Allard, Johane P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-d2edd5841b90e88ef4b174661bdaf532b9fe29a149059e24b089390595a065523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adults</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Anti-Infective Agents - adverse effects</topic><topic>Anti-Infective Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Anticoagulants</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Biofilms</topic><topic>blood flow</topic><topic>Catheter-Related Infections - diagnosis</topic><topic>Catheter-Related Infections - microbiology</topic><topic>Catheter-Related Infections - prevention & control</topic><topic>Catheterization, Central Venous - adverse effects</topic><topic>Catheterization, Central Venous - instrumentation</topic><topic>Catheters</topic><topic>Catheters, Indwelling - adverse effects</topic><topic>Central Venous Catheters - adverse effects</topic><topic>Clinical trials</topic><topic>Colonization</topic><topic>Drug Resistance, Bacterial</topic><topic>Ethanol</topic><topic>Gastroenterology</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Infections</topic><topic>Medical instruments</topic><topic>methodology</topic><topic>microbial colonization</topic><topic>Microorganisms</topic><topic>Morbidity</topic><topic>mortality</topic><topic>Nutrition</topic><topic>parenteral feeding</topic><topic>Parenteral nutrition</topic><topic>Parenteral Nutrition, Home - adverse effects</topic><topic>Parenteral Nutrition, Home - instrumentation</topic><topic>Patients</topic><topic>Prevention</topic><topic>Protective Factors</topic><topic>Review</topic><topic>Risk Factors</topic><topic>Systematic review</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Noelting, Jessica</creatorcontrib><creatorcontrib>Jurewitsch, Brian</creatorcontrib><creatorcontrib>Allard, Johane P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Noelting, Jessica</au><au>Jurewitsch, Brian</au><au>Allard, Johane P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-Antibiotic Antimicrobial Catheter Lock Solutions in Patients on Home Parenteral Nutrition</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2018-08-25</date><risdate>2018</risdate><volume>10</volume><issue>9</issue><spage>1165</spage><pages>1165-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Patients on home parenteral nutrition (HPN) are dependent on central venous access for long-term sustenance, and catheter-related bloodstream infections (CRBSIs) are a major cause of morbidity and mortality in this patient population. As such, there is much interest in finding new methods for preventing CRBSIs in patients on HPN. As it is thought that these infections are preceded by microbial colonization of the catheter, one approach is to use antimicrobial catheter lock solutions. Although antibiotic catheter lock solutions have been present for decades, their use has been mostly limited to the treatment of CRBSIs due to concern for promoting microbial resistance. Recently, however, with the advent of non-antibiotic antimicrobial catheter lock solutions, this approach is gaining popularity as a promising method to decrease rates of CRBSI in HPN patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30149607</pmid><doi>10.3390/nu10091165</doi><orcidid>https://orcid.org/0000-0002-5826-6229</orcidid><orcidid>https://orcid.org/0000-0002-8956-7059</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2018-08, Vol.10 (9), p.1165 |
| issn | 2072-6643 2072-6643 |
| language | eng |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adults Anti-Bacterial Agents - therapeutic use Anti-Infective Agents - adverse effects Anti-Infective Agents - therapeutic use Antibiotics Anticoagulants Antiinfectives and antibacterials Antimicrobial agents Biofilms blood flow Catheter-Related Infections - diagnosis Catheter-Related Infections - microbiology Catheter-Related Infections - prevention & control Catheterization, Central Venous - adverse effects Catheterization, Central Venous - instrumentation Catheters Catheters, Indwelling - adverse effects Central Venous Catheters - adverse effects Clinical trials Colonization Drug Resistance, Bacterial Ethanol Gastroenterology Hemodialysis Humans Infections Medical instruments methodology microbial colonization Microorganisms Morbidity mortality Nutrition parenteral feeding Parenteral nutrition Parenteral Nutrition, Home - adverse effects Parenteral Nutrition, Home - instrumentation Patients Prevention Protective Factors Review Risk Factors Systematic review Treatment Outcome |
| title | Non-Antibiotic Antimicrobial Catheter Lock Solutions in Patients on Home Parenteral Nutrition |
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