Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na⁺/K⁺-ATPase Profibrotic Signaling Pathways

Cardiotonic steroids (CTS) are Na⁺/K⁺-ATPase (NKA) ligands that are elevated in volume-expanded states and associated with cardiac and renal dysfunction in both clinical and experimental settings. We test the hypothesis that the CTS telocinobufagin (TCB) promotes renal dysfunction in a process invol...

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Veröffentlicht in:	International journal of molecular sciences 2018-08, Vol.19 (9), p.2566
Hauptverfasser:	Kennedy, David J, Khalaf, Fatimah K, Sheehy, Brendan, Weber, Malory E, Agatisa-Boyle, Brendan, Conic, Julijana, Hauser, Kayla, Medert, Charles M, Westfall, Kristen, Bucur, Philip, Fedorova, Olga V, Bagrov, Alexei Y, Tang, W H Wilson
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Blood pressure Bufanolides - metabolism Bufanolides - pharmacology Cardiomyopathy Cell Line Collagen Connective tissue growth factor Cystatin C Fibroblasts Fibrosis Fibrosis - metabolism Glycogen Synthase Kinase 3 beta - metabolism Growth factors Hormones Hypertension Kidney diseases Kidney Diseases - metabolism Kinases MAP Kinase Signaling System - drug effects Medicine Mesangial cells Metabolism Mice Mortality mRNA Na+/K+-exchanging ATPase Ouabain - pharmacology Phosphorylation - drug effects Proteinuria Renal function Signal transduction Signal Transduction - drug effects Sodium-Potassium-Exchanging ATPase - metabolism Steroid hormones Steroids Swine Urine
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