ATP-Induced Increase in Intracellular Calcium Levels and Subsequent Activation of mTOR as Regulators of Skeletal Muscle Hypertrophy

Intracellular signaling pathways, including the mammalian target of rapamycin (mTOR) and the mitogen-activated protein kinase (MAPK) pathway, are activated by exercise, and promote skeletal muscle hypertrophy. However, the mechanisms by which these pathways are activated by physiological stimulation...

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Veröffentlicht in:	International journal of molecular sciences 2018-09, Vol.19 (9), p.2804
Hauptverfasser:	Ito, Naoki, Ruegg, Urs T, Takeda, Shin'ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine Triphosphate - metabolism Animals Atrophy Calcium (intracellular) Calcium - metabolism Calcium ions Cell Line Extracellular signal-regulated kinase Hypertrophy Hypertrophy - metabolism Hypertrophy - pathology Inositol 1,4,5-trisphosphate receptors Insulin-like growth factors Interleukin 6 Intracellular Intracellular signalling JunB protein Kinases Male MAP kinase Mechanical stimuli Metabolism Mice, Inbred C57BL Muscle contraction Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles Muscular Atrophy - metabolism Muscular Atrophy - pathology Musculoskeletal system Phosphorylation Physiology Protein kinase Protein synthesis Proteins Quantitative analysis Rapamycin Regulators Signal transduction Skeletal muscle Soleus muscle Stimulation Therapeutic applications TOR protein TOR Serine-Threonine Kinases - metabolism
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