Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin

Resistance to cisplatin (CDDP) is a major cause of cancer treatment failure, including human breast cancer. The tumor suppressor protein p53 is a key factor in the induction of cell cycle arrest, DNA repair, and apoptosis in response to cellular stimuli. This protein is phosphorylated in serine 15 a...

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Veröffentlicht in:	Nutrients 2018-08, Vol.10 (9), p.1148
Hauptverfasser:	Hernandez-Valencia, Jorge, Garcia-Villa, Enrique, Arenas-Hernandez, Aquetzalli, Garcia-Mena, Jaime, Diaz-Chavez, Jose, Gariglio, Patricio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects BAX protein Bcl-2 protein bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Breast cancer breast neoplasms Cell cycle cell cycle checkpoints Cell Survival - drug effects Checkpoint Kinase 2 - genetics Checkpoint Kinase 2 - metabolism Chemosensitization Chemotherapy CHK2 protein Cisplatin Cisplatin - pharmacology Deoxyribonucleic acid Dephosphorylation DNA DNA damage DNA repair Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Gene Silencing Genes human cell lines Humans Inhibition Kinases MCF-7 Cells neoplasm cells p53 Protein Phenols Phosphorylation phosphotransferases (kinases) protein synthesis Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Repair Resveratrol Resveratrol - pharmacology Serine Serine - chemistry Tumor cells Tumor suppressor genes tumor suppressor protein p53 Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - genetics Tumors
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