Druggability of the guanosine/adenosine/cytidine nucleoside hydrolase from Trichomonas vaginalis

Trichomonas vaginalis infects approximately 300 million people worldwide annually. Infected individuals have a higher susceptibility to more serious conditions such as cervical and prostate cancer. The parasite has developed increasing resistance to current drug therapies, with an estimated 5% of cl...

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Veröffentlicht in:	Chemical biology & drug design 2018-10, Vol.92 (4), p.1736-1742
Hauptverfasser:	Alam, Rayyan, Barbarovich, Allen T., Caravan, Wagma, Ismail, Mirna, Barskaya, Angela, Parkin, David W., Stockman, Brian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Inhibitory Concentration 50 N-Glycosyl Hydrolases - antagonists & inhibitors N-Glycosyl Hydrolases - metabolism NIH clinical compound collection NMR nucleoside hydrolase Protozoan Proteins - antagonists & inhibitors Protozoan Proteins - metabolism Quercetin - analogs & derivatives Quercetin - chemistry Quercetin - metabolism ribavirin Ribavirin - chemistry Ribavirin - metabolism Structure-Activity Relationship Trichomonas vaginalis Trichomonas vaginalis - enzymology
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