G9a Correlates with VLA-4 Integrin and Influences the Migration of Childhood Acute Lymphoblastic Leukemia Cells

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. As ALL progresses, leukemic cells cross the endothelial barrier and infiltrate other tissues. Epigenetic enzymes represent novel therapeutic targets in hematological malignancies, and might contribute to cells' capacity to...

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Veröffentlicht in:	Cancers 2018-09, Vol.10 (9), p.325
Hauptverfasser:	Madrazo, Elena, Ruano, David, Abad, Lorea, Alonso-Gómez, Estefanía, Sánchez-Valdepeñas, Carmen, González-Murillo, África, Ramírez, Manuel, Redondo-Muñoz, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Acute lymphoblastic leukemia Bone marrow Cancer Cell adhesion & migration Cell migration Children Cytoskeleton Enzymes Epigenetics Gene expression Gene silencing Histone methyltransferase Immunology Leukemia Lymphatic leukemia Medical prognosis Nuclei Pediatrics Phenotypes Polymerization Therapeutic applications Trends VLA-4 antigen
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