Transcriptome Signatures of Canine Mammary Gland Tumors and Its Comparison to Human Breast Cancers
Breast cancer (BC)/mammary gland carcinoma (MGC) is the most frequently diagnosed and leading cause of cancer-related mortality in both women and canines. To better understand both canine MGC and human BC-specific genes, we sequenced RNAs obtained from eight pairs of carcinomas and adjacent normal t...
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| Veröffentlicht in: | Cancers 2018-09, Vol.10 (9), p.317 |
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| creator | Lee, Kang-Hoon Park, Hyoung-Min Son, Keun-Hong Shin, Tae-Jin Cho, Je-Yoel |
| description | Breast cancer (BC)/mammary gland carcinoma (MGC) is the most frequently diagnosed and leading cause of cancer-related mortality in both women and canines. To better understand both canine MGC and human BC-specific genes, we sequenced RNAs obtained from eight pairs of carcinomas and adjacent normal tissues in dogs. By comprehensive transcriptome analysis, 351 differentially expressed genes (DEGs) were identified in overall canine MGCs. Based on the DEGs, comparative analysis revealed correlation existing among the three histological subtypes of canine MGC (ductal, simple, and complex) and four molecular subtypes of human BC (HER2+, ER+, ER&HER2+, and TNBC). Eight DEGs shared by all three subtypes of canine MGCs had been previously reported as cancer-associated genes in human studies. Gene ontology and pathway analyses using the identified DEGs revealed that the biological processes of cell proliferation, adhesion, and inflammatory responses are enriched in up-regulated MGC DEGs. In contrast, fatty acid homeostasis and transcription regulation involved in cell fate commitment were down-regulated in MGC DEGs. Moreover, correlations are demonstrated between upstream promoter transcripts and DEGs. Canine MGC- and subtype-enriched gene expression allows us to better understand both human BC and canine MGC, yielding new insight into the development of biomarkers and targets for both diseases. |
| doi_str_mv | 10.3390/cancers10090317 |
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To better understand both canine MGC and human BC-specific genes, we sequenced RNAs obtained from eight pairs of carcinomas and adjacent normal tissues in dogs. By comprehensive transcriptome analysis, 351 differentially expressed genes (DEGs) were identified in overall canine MGCs. Based on the DEGs, comparative analysis revealed correlation existing among the three histological subtypes of canine MGC (ductal, simple, and complex) and four molecular subtypes of human BC (HER2+, ER+, ER&HER2+, and TNBC). Eight DEGs shared by all three subtypes of canine MGCs had been previously reported as cancer-associated genes in human studies. Gene ontology and pathway analyses using the identified DEGs revealed that the biological processes of cell proliferation, adhesion, and inflammatory responses are enriched in up-regulated MGC DEGs. In contrast, fatty acid homeostasis and transcription regulation involved in cell fate commitment were down-regulated in MGC DEGs. Moreover, correlations are demonstrated between upstream promoter transcripts and DEGs. Canine MGC- and subtype-enriched gene expression allows us to better understand both human BC and canine MGC, yielding new insight into the development of biomarkers and targets for both diseases.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers10090317</identifier><identifier>PMID: 30205506</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biomarkers ; Breast cancer ; Carcinoma ; Cell fate ; Cell proliferation ; Comparative analysis ; Dogs ; Epigenetics ; ErbB-2 protein ; Gene expression ; Gene regulation ; Genomes ; Growth factors ; Homeostasis ; Inflammation ; Mammary gland ; Metastasis ; Principal components analysis ; Studies ; Transcription ; Tumors ; Veterinary medicine</subject><ispartof>Cancers, 2018-09, Vol.10 (9), p.317</ispartof><rights>2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-5d31f00214c603c47541083b927bd32368798b19c2571d6bf37759be984e54d13</citedby><cites>FETCH-LOGICAL-c487t-5d31f00214c603c47541083b927bd32368798b19c2571d6bf37759be984e54d13</cites><orcidid>0000-0003-1030-3577</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162473/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162473/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30205506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Kang-Hoon</creatorcontrib><creatorcontrib>Park, Hyoung-Min</creatorcontrib><creatorcontrib>Son, Keun-Hong</creatorcontrib><creatorcontrib>Shin, Tae-Jin</creatorcontrib><creatorcontrib>Cho, Je-Yoel</creatorcontrib><title>Transcriptome Signatures of Canine Mammary Gland Tumors and Its Comparison to Human Breast Cancers</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Breast cancer (BC)/mammary gland carcinoma (MGC) is the most frequently diagnosed and leading cause of cancer-related mortality in both women and canines. To better understand both canine MGC and human BC-specific genes, we sequenced RNAs obtained from eight pairs of carcinomas and adjacent normal tissues in dogs. By comprehensive transcriptome analysis, 351 differentially expressed genes (DEGs) were identified in overall canine MGCs. Based on the DEGs, comparative analysis revealed correlation existing among the three histological subtypes of canine MGC (ductal, simple, and complex) and four molecular subtypes of human BC (HER2+, ER+, ER&HER2+, and TNBC). Eight DEGs shared by all three subtypes of canine MGCs had been previously reported as cancer-associated genes in human studies. Gene ontology and pathway analyses using the identified DEGs revealed that the biological processes of cell proliferation, adhesion, and inflammatory responses are enriched in up-regulated MGC DEGs. In contrast, fatty acid homeostasis and transcription regulation involved in cell fate commitment were down-regulated in MGC DEGs. Moreover, correlations are demonstrated between upstream promoter transcripts and DEGs. Canine MGC- and subtype-enriched gene expression allows us to better understand both human BC and canine MGC, yielding new insight into the development of biomarkers and targets for both diseases.</description><subject>Biomarkers</subject><subject>Breast cancer</subject><subject>Carcinoma</subject><subject>Cell fate</subject><subject>Cell proliferation</subject><subject>Comparative analysis</subject><subject>Dogs</subject><subject>Epigenetics</subject><subject>ErbB-2 protein</subject><subject>Gene expression</subject><subject>Gene regulation</subject><subject>Genomes</subject><subject>Growth factors</subject><subject>Homeostasis</subject><subject>Inflammation</subject><subject>Mammary gland</subject><subject>Metastasis</subject><subject>Principal components analysis</subject><subject>Studies</subject><subject>Transcription</subject><subject>Tumors</subject><subject>Veterinary medicine</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkcFLwzAYxYMobkzP3iTgxcv0S9ImzUXQodtA8eA8hzRNZ8eazKQV_O9tmY65HJIP8vse7_EQuiBww5iEW6OdsSESAAmMiCM0pCDomHOZHO_NA3Qe4wq6wzqKi1M0YEAhTYEPUb4I2kUTqk3ja4vfqqXTTRtsxL7EE-0qZ_GLrmsdvvF0rV2BF23tQ8T9OG8invh6o0MVvcONx7O21g4_BKtj06_3_s7QSanX0Z7_viP0_vS4mMzGz6_T-eT-eWySTDTjtGCkBKAkMRyYSUSaEMhYLqnIC0YZz4TMciINTQUpeF4yIVKZW5klNk0Kwkbobqu7afPaFsa6Jui12oSqd6-8rtT_H1d9qKX_UpxwmgjWCVz_CgT_2drYqLqKxq672Na3UVECVPZXj14doCvfBtfF6ygqSAaS9I5ut5QJPsZgy50ZAqqvUB1U2G1c7mfY8X-FsR-B-peH</recordid><startdate>20180907</startdate><enddate>20180907</enddate><creator>Lee, Kang-Hoon</creator><creator>Park, Hyoung-Min</creator><creator>Son, Keun-Hong</creator><creator>Shin, Tae-Jin</creator><creator>Cho, Je-Yoel</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1030-3577</orcidid></search><sort><creationdate>20180907</creationdate><title>Transcriptome Signatures of Canine Mammary Gland Tumors and Its Comparison to Human Breast Cancers</title><author>Lee, Kang-Hoon ; Park, Hyoung-Min ; Son, Keun-Hong ; Shin, Tae-Jin ; Cho, Je-Yoel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-5d31f00214c603c47541083b927bd32368798b19c2571d6bf37759be984e54d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biomarkers</topic><topic>Breast cancer</topic><topic>Carcinoma</topic><topic>Cell fate</topic><topic>Cell proliferation</topic><topic>Comparative analysis</topic><topic>Dogs</topic><topic>Epigenetics</topic><topic>ErbB-2 protein</topic><topic>Gene expression</topic><topic>Gene regulation</topic><topic>Genomes</topic><topic>Growth factors</topic><topic>Homeostasis</topic><topic>Inflammation</topic><topic>Mammary gland</topic><topic>Metastasis</topic><topic>Principal components analysis</topic><topic>Studies</topic><topic>Transcription</topic><topic>Tumors</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Kang-Hoon</creatorcontrib><creatorcontrib>Park, Hyoung-Min</creatorcontrib><creatorcontrib>Son, Keun-Hong</creatorcontrib><creatorcontrib>Shin, Tae-Jin</creatorcontrib><creatorcontrib>Cho, Je-Yoel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Kang-Hoon</au><au>Park, Hyoung-Min</au><au>Son, Keun-Hong</au><au>Shin, Tae-Jin</au><au>Cho, Je-Yoel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptome Signatures of Canine Mammary Gland Tumors and Its Comparison to Human Breast Cancers</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2018-09-07</date><risdate>2018</risdate><volume>10</volume><issue>9</issue><spage>317</spage><pages>317-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Breast cancer (BC)/mammary gland carcinoma (MGC) is the most frequently diagnosed and leading cause of cancer-related mortality in both women and canines. To better understand both canine MGC and human BC-specific genes, we sequenced RNAs obtained from eight pairs of carcinomas and adjacent normal tissues in dogs. By comprehensive transcriptome analysis, 351 differentially expressed genes (DEGs) were identified in overall canine MGCs. Based on the DEGs, comparative analysis revealed correlation existing among the three histological subtypes of canine MGC (ductal, simple, and complex) and four molecular subtypes of human BC (HER2+, ER+, ER&HER2+, and TNBC). Eight DEGs shared by all three subtypes of canine MGCs had been previously reported as cancer-associated genes in human studies. Gene ontology and pathway analyses using the identified DEGs revealed that the biological processes of cell proliferation, adhesion, and inflammatory responses are enriched in up-regulated MGC DEGs. In contrast, fatty acid homeostasis and transcription regulation involved in cell fate commitment were down-regulated in MGC DEGs. Moreover, correlations are demonstrated between upstream promoter transcripts and DEGs. Canine MGC- and subtype-enriched gene expression allows us to better understand both human BC and canine MGC, yielding new insight into the development of biomarkers and targets for both diseases.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30205506</pmid><doi>10.3390/cancers10090317</doi><orcidid>https://orcid.org/0000-0003-1030-3577</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers Breast cancer Carcinoma Cell fate Cell proliferation Comparative analysis Dogs Epigenetics ErbB-2 protein Gene expression Gene regulation Genomes Growth factors Homeostasis Inflammation Mammary gland Metastasis Principal components analysis Studies Transcription Tumors Veterinary medicine |
| title | Transcriptome Signatures of Canine Mammary Gland Tumors and Its Comparison to Human Breast Cancers |
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