Malaria vaccine candidate based on Duffy-binding protein elicits strain transcending functional antibodies in a Phase I trial

Reticulocyte invasion by Plasmodium vivax requires interaction of the Duffy-binding protein (PvDBP) with host Duffy antigen receptor for chemokines (DARCs). The binding domain of PvDBP maps to a cysteine-rich region referred to as region II (PvDBPII). Blocking this interaction offers a potential pat...

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Veröffentlicht in:	npj vaccines 2018-09, Vol.3 (1), p.48-48, Article 48
Hauptverfasser:	Singh, Kavita, Mukherjee, Paushali, Shakri, Ahmad Rushdi, Singh, Ankita, Pandey, Gaurav, Bakshi, Meenakshi, Uppal, Geetanjali, Jena, Rajender, Rawat, Ankita, Kumar, Purnima, Bhardwaj, Rukmini, Yazdani, Syed Shams, Hans, Dhiraj, Mehta, Shantanu, Srinivasan, Ajay, Anil, K., Madhusudhan, R. L., Patel, Jaya, Singh, Amit, Rao, Rajeshwar, Gangireddy, Santosh, Patil, Rudrappa, Kaviraj, Swarnendu, Singh, Sanjay, Carter, Darrick, Reed, Steve, Kaslow, David C., Birkett, Ashley, Chauhan, Virander S., Chitnis, Chetan E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/590 692/699/255/1629 Antigens Biomedical and Life Sciences Biomedicine Immunoglobulins Infectious Diseases Malaria Medical Microbiology Public Health Vaccine Vaccines Virology
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