IFITM proteins inhibit HIV-1 protein synthesis

Interferon induced transmembrane proteins (IFITMs) inhibit the cellular entry of a broad range of viruses, but it has been suspected that for HIV-1 IFITMs may also inhibit a post-integration replicative step. We show that IFITM expression reduces HIV-1 viral protein synthesis by preferentially exclu...

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Veröffentlicht in:	Scientific reports 2018-09, Vol.8 (1), p.14551-15, Article 14551
Hauptverfasser:	Lee, Wing-Yiu Jason, Fu, Rebecca Menhua, Liang, Chen, Sloan, Richard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/31 13/89 38 38/77 38/90 631/250/262 631/326/596/1787 Antigens, Differentiation - metabolism Deoxyribonucleic acid DNA HEK293 Cells HIV HIV Infections - metabolism HIV-1 - physiology Human immunodeficiency virus Humanities and Social Sciences Humans Interferon Membrane proteins Membrane Proteins - metabolism multidisciplinary Nef protein Protein Biosynthesis Protein synthesis Proteins RNA-Binding Proteins - metabolism Science Science (multidisciplinary) Translation Viral Proteins - metabolism Virus Replication
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