MiR-532-5p suppresses renal cancer cell proliferation by disrupting the ETS1-mediated positive feedback loop with the KRAS-NAP1L1/P-ERK axis

Background Despite the fact that miRNAs play pivotal roles in various human malignancies, their molecular mechanisms influencing RCC are poorly understood. Methods The expression of miRNAs from RCC and paired normal renal specimens was analysed by a combined computational and experimental approach u...

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Veröffentlicht in:	British journal of cancer 2018-08, Vol.119 (5), p.591-604
Hauptverfasser:	Zhai, Wei, Ma, Junjie, Zhu, Rujian, Xu, Chen, Zhang, Jin, Chen, Yonghui, Chen, Zhiguo, Gong, Dongkui, Zheng, Jiayi, Chen, Chen, Li, Saiyang, Li, Butang, Huang, Yiran, Xue, Wei, Zheng, Junhua
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/331 631/67/1857 631/80/83 A549 Cells Animals Assaying Bioinformatics Biomedical and Life Sciences Biomedicine Cancer Cancer Research Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell growth Cell Line, Tumor Cell proliferation Chromatin Computer applications Disruption Down-Regulation Drug Resistance Epidemiology Ets-1 protein Extracellular signal-regulated kinase Feedback Feedback loops Feedback, Physiological Gene Expression Regulation, Neoplastic Humans Immunoprecipitation K-Ras protein Kidney cancer Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kinases Male MAP Kinase Signaling System Mice MicroRNAs - metabolism Molecular Medicine Molecular modelling Neoplasm Transplantation Nucleosome Assembly Protein 1 - genetics Nucleosome Assembly Protein 1 - metabolism Oncology Phosphorylation Positive feedback Prognosis Promoter Regions, Genetic Proto-Oncogene Protein c-ets-1 - genetics Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Renal cell carcinoma Survival Analysis Transcription Western blotting
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