Sex differences in associations among metabolic syndrome, obesity, related biomarkers, and colorectal adenomatous polyp risk in a Japanese population
To investigate sex differences in the associations among metabolic syndrome, obesity, adipose tissue-related biomarkers, and colorectal adenomatous polyps, a cross-sectional, multicenter study was conducted on 489 consecutive individuals who underwent their first colonoscopy at 3 hospitals. Plasma c...
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| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 2018, Vol.63(2), pp.154-163 |
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| creator | Nakai, Keisuke Watari, Jiro Tozawa, Katsuyuki Tamura, Akio Hara, Ken Yamasaki, Takahisa Kondo, Takashi Kono, Tomoaki Tomita, Toshihiko Ohda, Yoshio Oshima, Tadayuki Fukui, Hirokazu Sakurai, Jun Kim, Yongmin Hayakawa, Yuji Fujisawa, Takashi Morimoto, Takeshi Miwa, Hiroto |
| description | To investigate sex differences in the associations among metabolic syndrome, obesity, adipose tissue-related biomarkers, and colorectal adenomatous polyps, a cross-sectional, multicenter study was conducted on 489 consecutive individuals who underwent their first colonoscopy at 3 hospitals. Plasma concentrations of adiponectin and leptin, as well as homeostatic model assessment of insulin resistance were also evaluated. The presence and number of adenomatous polyps, including advanced adenoma, were higher in men than in women. Metabolic syndrome was a risk factor for adenomatous polyps in both sexes. Large waist circumference was an independent risk factor for adenomatous polyps in men, and high BMI and large waist circumference were risk factors for adenomatous polyps in women. Interestingly, low BMI was associated with large adenomatous polyps (≥10 mm) and advanced adenoma, and waist-hip ratio was involved in proximal adenomatous polyp development only in women. In contrast, the highest quartile of leptin concentration had a 3.67-fold increased adenomatous polyp risk compared with the lowest quartile only in men. These results indicate that regarding colorectal pathogenesis, sex differences were identified in obesity but not in metabolic syndrome. Visceral obesity and a high serum leptin level may be risk factors for colorectal adenomatous polyp development in Japanese men. |
| doi_str_mv | 10.3164/jcbn.18-11 |
| format | Article |
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Plasma concentrations of adiponectin and leptin, as well as homeostatic model assessment of insulin resistance were also evaluated. The presence and number of adenomatous polyps, including advanced adenoma, were higher in men than in women. Metabolic syndrome was a risk factor for adenomatous polyps in both sexes. Large waist circumference was an independent risk factor for adenomatous polyps in men, and high BMI and large waist circumference were risk factors for adenomatous polyps in women. Interestingly, low BMI was associated with large adenomatous polyps (≥10 mm) and advanced adenoma, and waist-hip ratio was involved in proximal adenomatous polyp development only in women. In contrast, the highest quartile of leptin concentration had a 3.67-fold increased adenomatous polyp risk compared with the lowest quartile only in men. These results indicate that regarding colorectal pathogenesis, sex differences were identified in obesity but not in metabolic syndrome. Visceral obesity and a high serum leptin level may be risk factors for colorectal adenomatous polyp development in Japanese men.</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.18-11</identifier><identifier>PMID: 30279628</identifier><language>eng</language><publisher>Japan: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>Adenoma ; adipokine ; Adiponectin ; Adipose tissue ; Biomarkers ; Body mass ; Colon ; colorectal adenoma ; Gender aspects ; Gender differences ; Hip ; Insulin ; Leptin ; Men ; Metabolic disorders ; Metabolic syndrome ; Obesity ; Original ; Pathogenesis ; Polyps ; Risk analysis ; Risk factors ; Sex ; sex difference ; Sex differences ; Tumors ; visceral obesity ; Women</subject><ispartof>Journal of Clinical Biochemistry and Nutrition, 2018, Vol.63(2), pp.154-163</ispartof><rights>2018 JCBN</rights><rights>Copyright Japan Science and Technology Agency 2018</rights><rights>Copyright © 2018 JCBN 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c712t-3619494cea09a13358e18390a1dc2cfd753382db995288ffb49fbdae31162bad3</citedby><cites>FETCH-LOGICAL-c712t-3619494cea09a13358e18390a1dc2cfd753382db995288ffb49fbdae31162bad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160732/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160732/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,1877,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30279628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakai, Keisuke</creatorcontrib><creatorcontrib>Watari, Jiro</creatorcontrib><creatorcontrib>Tozawa, Katsuyuki</creatorcontrib><creatorcontrib>Tamura, Akio</creatorcontrib><creatorcontrib>Hara, Ken</creatorcontrib><creatorcontrib>Yamasaki, Takahisa</creatorcontrib><creatorcontrib>Kondo, Takashi</creatorcontrib><creatorcontrib>Kono, Tomoaki</creatorcontrib><creatorcontrib>Tomita, Toshihiko</creatorcontrib><creatorcontrib>Ohda, Yoshio</creatorcontrib><creatorcontrib>Oshima, Tadayuki</creatorcontrib><creatorcontrib>Fukui, Hirokazu</creatorcontrib><creatorcontrib>Sakurai, Jun</creatorcontrib><creatorcontrib>Kim, Yongmin</creatorcontrib><creatorcontrib>Hayakawa, Yuji</creatorcontrib><creatorcontrib>Fujisawa, Takashi</creatorcontrib><creatorcontrib>Morimoto, Takeshi</creatorcontrib><creatorcontrib>Miwa, Hiroto</creatorcontrib><title>Sex differences in associations among metabolic syndrome, obesity, related biomarkers, and colorectal adenomatous polyp risk in a Japanese population</title><title>Journal of Clinical Biochemistry and Nutrition</title><addtitle>J. Clin. Biochem. Nutr.</addtitle><description>To investigate sex differences in the associations among metabolic syndrome, obesity, adipose tissue-related biomarkers, and colorectal adenomatous polyps, a cross-sectional, multicenter study was conducted on 489 consecutive individuals who underwent their first colonoscopy at 3 hospitals. Plasma concentrations of adiponectin and leptin, as well as homeostatic model assessment of insulin resistance were also evaluated. The presence and number of adenomatous polyps, including advanced adenoma, were higher in men than in women. Metabolic syndrome was a risk factor for adenomatous polyps in both sexes. Large waist circumference was an independent risk factor for adenomatous polyps in men, and high BMI and large waist circumference were risk factors for adenomatous polyps in women. Interestingly, low BMI was associated with large adenomatous polyps (≥10 mm) and advanced adenoma, and waist-hip ratio was involved in proximal adenomatous polyp development only in women. In contrast, the highest quartile of leptin concentration had a 3.67-fold increased adenomatous polyp risk compared with the lowest quartile only in men. These results indicate that regarding colorectal pathogenesis, sex differences were identified in obesity but not in metabolic syndrome. Visceral obesity and a high serum leptin level may be risk factors for colorectal adenomatous polyp development in Japanese men.</description><subject>Adenoma</subject><subject>adipokine</subject><subject>Adiponectin</subject><subject>Adipose tissue</subject><subject>Biomarkers</subject><subject>Body mass</subject><subject>Colon</subject><subject>colorectal adenoma</subject><subject>Gender aspects</subject><subject>Gender differences</subject><subject>Hip</subject><subject>Insulin</subject><subject>Leptin</subject><subject>Men</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Obesity</subject><subject>Original</subject><subject>Pathogenesis</subject><subject>Polyps</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Sex</subject><subject>sex difference</subject><subject>Sex differences</subject><subject>Tumors</subject><subject>visceral obesity</subject><subject>Women</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkc2KFDEUhQtRnHZ04wNIwI1I15ifqnRqI8rgLwMu1HW4lbrVk55UUpOkxX4Q39d099ioEG4W5-PcezhV9ZTRC8Fk82pjen_BVM3YvWrBlKJ1S5W8Xy1ox3hNKe3OqkcpbShtZCubh9WZoHzVSa4W1a-v-JMMdhwxojeYiPUEUgrGQrbBJwJT8GsyYYY-OGtI2vkhhgmXJPSYbN4tSUQHGQfS2zBBvMGYlgT8QExwIaLJ4AgM6IuYwzaRObjdTKJNN4dl5DPM4DFhEeatO6x9XD0YwSV8cvefV9_fv_t2-bG--vLh0-Xbq9qsGM-1kKxrusYg0A6YEK1CpkRHgQ2Gm3FYtUIoPvRd13KlxrFvurEfAAVjkvcwiPPq9dF33vYTDgZ9juD0HG0JstMBrP5X8fZar8MPLZmkK8GLwYs7gxhut5iynmwy6FxJVLJqXjaV10pZ0Of_oZuwjb7E05w3jEvKDtTLI2ViSCnieDqGUb1vW-_b1kxpxgr87O_zT-ifegvw5ghsUoY1ngCI2RqHRy8pNN-Pg-dJMtcQNXrxGw-RwRA</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Nakai, Keisuke</creator><creator>Watari, Jiro</creator><creator>Tozawa, Katsuyuki</creator><creator>Tamura, Akio</creator><creator>Hara, Ken</creator><creator>Yamasaki, Takahisa</creator><creator>Kondo, Takashi</creator><creator>Kono, Tomoaki</creator><creator>Tomita, Toshihiko</creator><creator>Ohda, Yoshio</creator><creator>Oshima, Tadayuki</creator><creator>Fukui, Hirokazu</creator><creator>Sakurai, Jun</creator><creator>Kim, Yongmin</creator><creator>Hayakawa, Yuji</creator><creator>Fujisawa, Takashi</creator><creator>Morimoto, Takeshi</creator><creator>Miwa, Hiroto</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>Japan Science and Technology Agency</general><general>the Society for Free Radical Research Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180101</creationdate><title>Sex differences in associations among metabolic syndrome, obesity, related biomarkers, and colorectal adenomatous polyp risk in a Japanese population</title><author>Nakai, Keisuke ; Watari, Jiro ; Tozawa, Katsuyuki ; Tamura, Akio ; Hara, Ken ; Yamasaki, Takahisa ; Kondo, Takashi ; Kono, Tomoaki ; Tomita, Toshihiko ; Ohda, Yoshio ; Oshima, Tadayuki ; Fukui, Hirokazu ; Sakurai, Jun ; Kim, Yongmin ; Hayakawa, Yuji ; Fujisawa, Takashi ; Morimoto, Takeshi ; Miwa, Hiroto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c712t-3619494cea09a13358e18390a1dc2cfd753382db995288ffb49fbdae31162bad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenoma</topic><topic>adipokine</topic><topic>Adiponectin</topic><topic>Adipose tissue</topic><topic>Biomarkers</topic><topic>Body mass</topic><topic>Colon</topic><topic>colorectal adenoma</topic><topic>Gender aspects</topic><topic>Gender differences</topic><topic>Hip</topic><topic>Insulin</topic><topic>Leptin</topic><topic>Men</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Obesity</topic><topic>Original</topic><topic>Pathogenesis</topic><topic>Polyps</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Sex</topic><topic>sex difference</topic><topic>Sex differences</topic><topic>Tumors</topic><topic>visceral obesity</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakai, Keisuke</creatorcontrib><creatorcontrib>Watari, Jiro</creatorcontrib><creatorcontrib>Tozawa, Katsuyuki</creatorcontrib><creatorcontrib>Tamura, Akio</creatorcontrib><creatorcontrib>Hara, Ken</creatorcontrib><creatorcontrib>Yamasaki, Takahisa</creatorcontrib><creatorcontrib>Kondo, Takashi</creatorcontrib><creatorcontrib>Kono, Tomoaki</creatorcontrib><creatorcontrib>Tomita, Toshihiko</creatorcontrib><creatorcontrib>Ohda, Yoshio</creatorcontrib><creatorcontrib>Oshima, Tadayuki</creatorcontrib><creatorcontrib>Fukui, Hirokazu</creatorcontrib><creatorcontrib>Sakurai, Jun</creatorcontrib><creatorcontrib>Kim, Yongmin</creatorcontrib><creatorcontrib>Hayakawa, Yuji</creatorcontrib><creatorcontrib>Fujisawa, Takashi</creatorcontrib><creatorcontrib>Morimoto, Takeshi</creatorcontrib><creatorcontrib>Miwa, Hiroto</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakai, Keisuke</au><au>Watari, Jiro</au><au>Tozawa, Katsuyuki</au><au>Tamura, Akio</au><au>Hara, Ken</au><au>Yamasaki, Takahisa</au><au>Kondo, Takashi</au><au>Kono, Tomoaki</au><au>Tomita, Toshihiko</au><au>Ohda, Yoshio</au><au>Oshima, Tadayuki</au><au>Fukui, Hirokazu</au><au>Sakurai, Jun</au><au>Kim, Yongmin</au><au>Hayakawa, Yuji</au><au>Fujisawa, Takashi</au><au>Morimoto, Takeshi</au><au>Miwa, Hiroto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in associations among metabolic syndrome, obesity, related biomarkers, and colorectal adenomatous polyp risk in a Japanese population</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>63</volume><issue>2</issue><spage>154</spage><epage>163</epage><pages>154-163</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>To investigate sex differences in the associations among metabolic syndrome, obesity, adipose tissue-related biomarkers, and colorectal adenomatous polyps, a cross-sectional, multicenter study was conducted on 489 consecutive individuals who underwent their first colonoscopy at 3 hospitals. Plasma concentrations of adiponectin and leptin, as well as homeostatic model assessment of insulin resistance were also evaluated. The presence and number of adenomatous polyps, including advanced adenoma, were higher in men than in women. Metabolic syndrome was a risk factor for adenomatous polyps in both sexes. Large waist circumference was an independent risk factor for adenomatous polyps in men, and high BMI and large waist circumference were risk factors for adenomatous polyps in women. Interestingly, low BMI was associated with large adenomatous polyps (≥10 mm) and advanced adenoma, and waist-hip ratio was involved in proximal adenomatous polyp development only in women. In contrast, the highest quartile of leptin concentration had a 3.67-fold increased adenomatous polyp risk compared with the lowest quartile only in men. These results indicate that regarding colorectal pathogenesis, sex differences were identified in obesity but not in metabolic syndrome. Visceral obesity and a high serum leptin level may be risk factors for colorectal adenomatous polyp development in Japanese men.</abstract><cop>Japan</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><pmid>30279628</pmid><doi>10.3164/jcbn.18-11</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenoma adipokine Adiponectin Adipose tissue Biomarkers Body mass Colon colorectal adenoma Gender aspects Gender differences Hip Insulin Leptin Men Metabolic disorders Metabolic syndrome Obesity Original Pathogenesis Polyps Risk analysis Risk factors Sex sex difference Sex differences Tumors visceral obesity Women |
| title | Sex differences in associations among metabolic syndrome, obesity, related biomarkers, and colorectal adenomatous polyp risk in a Japanese population |
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