Nitric Oxide–Releasing Macromolecular Scaffolds for Antibacterial Applications
Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO‐releasing macromolecular scaffolds are developed to faci...
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| Veröffentlicht in: | Advanced healthcare materials 2018-07, Vol.7 (13), p.e1800155-n/a |
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| creator | Yang, Lei Feura, Evan S. Ahonen, Mona Jasmine R. Schoenfisch, Mark H. |
| description | Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO‐releasing macromolecular scaffolds are developed to facilitate NO delivery. This progress report describes the rational design and application of NO‐releasing macromolecular scaffolds as antibacterial therapeutics. Special consideration is given to the role of the physicochemical properties of the NO storage vehicles on antibacterial or anti‐biofilm activity.
Developing novel therapies to combat drug‐resistant bacteria and biofilms infections is a vibrant research area. This review describes recent progress of nitric oxide‐releasing macromolecular scaffolds as antibacterial agents. The correlation between the physicochemical properties of the nitric oxide‐release systems and antimicrobial activity is presented to provide guidance on the rational design of nitric oxide‐based therapies. |
| doi_str_mv | 10.1002/adhm.201800155 |
| format | Article |
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Developing novel therapies to combat drug‐resistant bacteria and biofilms infections is a vibrant research area. This review describes recent progress of nitric oxide‐releasing macromolecular scaffolds as antibacterial agents. The correlation between the physicochemical properties of the nitric oxide‐release systems and antimicrobial activity is presented to provide guidance on the rational design of nitric oxide‐based therapies.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.201800155</identifier><identifier>PMID: 29756275</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Anti-Bacterial Agents - adverse effects ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; antibacterial ; Biofilms ; Biofilms - drug effects ; Humans ; Liposomes - chemistry ; macromolecular scaffolds ; Macromolecular Substances - chemistry ; Macromolecules ; Molecular Weight ; Nanoparticles - chemistry ; Nitrates - chemistry ; Nitric oxide ; Nitric Oxide - pharmacokinetics ; Nitric Oxide Donors - chemistry ; Nitric Oxide Donors - pharmacology ; Physicochemical properties ; Polymers - chemistry ; rational designs ; Releasing ; Scaffolds ; Surface Properties</subject><ispartof>Advanced healthcare materials, 2018-07, Vol.7 (13), p.e1800155-n/a</ispartof><rights>2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5715-4f3d9d671fbc7ca0db89d688bcc8b1c224113593ced0594e97e96db5844c75be3</citedby><cites>FETCH-LOGICAL-c5715-4f3d9d671fbc7ca0db89d688bcc8b1c224113593ced0594e97e96db5844c75be3</cites><orcidid>0000-0002-2212-0658</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.201800155$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.201800155$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29756275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Lei</creatorcontrib><creatorcontrib>Feura, Evan S.</creatorcontrib><creatorcontrib>Ahonen, Mona Jasmine R.</creatorcontrib><creatorcontrib>Schoenfisch, Mark H.</creatorcontrib><title>Nitric Oxide–Releasing Macromolecular Scaffolds for Antibacterial Applications</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO‐releasing macromolecular scaffolds are developed to facilitate NO delivery. This progress report describes the rational design and application of NO‐releasing macromolecular scaffolds as antibacterial therapeutics. Special consideration is given to the role of the physicochemical properties of the NO storage vehicles on antibacterial or anti‐biofilm activity.
Developing novel therapies to combat drug‐resistant bacteria and biofilms infections is a vibrant research area. This review describes recent progress of nitric oxide‐releasing macromolecular scaffolds as antibacterial agents. The correlation between the physicochemical properties of the nitric oxide‐release systems and antimicrobial activity is presented to provide guidance on the rational design of nitric oxide‐based therapies.</description><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antibacterial</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Humans</subject><subject>Liposomes - chemistry</subject><subject>macromolecular scaffolds</subject><subject>Macromolecular Substances - chemistry</subject><subject>Macromolecules</subject><subject>Molecular Weight</subject><subject>Nanoparticles - chemistry</subject><subject>Nitrates - chemistry</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - pharmacokinetics</subject><subject>Nitric Oxide Donors - chemistry</subject><subject>Nitric Oxide Donors - pharmacology</subject><subject>Physicochemical properties</subject><subject>Polymers - chemistry</subject><subject>rational designs</subject><subject>Releasing</subject><subject>Scaffolds</subject><subject>Surface Properties</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1OAyEUhYnR2KZ269JM4roVmIEZNiZN_amJWuPPmjDAtDR0qDBVu_MdfEOfREy16ko2F8K53z25B4B9BPsIQnwk1HTexxAVECJCtkAbI4Z7mBK2vblnsAW6IcxgPJQgWqBd0MIsJxTnpA1urk3jjUzGL0bp99e3W221CKaeJFdCejd3VsulFT65k6KqnFUhqZxPBnVjSiEb7Y2wyWCxsEaKxrg67IGdStigu1-1Ax7OTu-Ho97l-PxiOLjsSZIj0suqVDFFc1SVMpcCqrKIz6IopSxKJDHOEEoJS6VWkLBMs1wzqkpSZJnMSanTDjhecxfLcq6V1HXjheULb-bCr7gThv_9qc2UT9wTp4gwhrMIOPwCePe41KHhM7f0dfTMMaR5QaMbGFX9tSouIwSvq80EBPlnCPwzBL4JITYc_Pa1kX-vPArYWvBsrF79g-ODk9HVD_wDGZSWJQ</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>Yang, Lei</creator><creator>Feura, Evan S.</creator><creator>Ahonen, Mona Jasmine R.</creator><creator>Schoenfisch, Mark H.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2212-0658</orcidid></search><sort><creationdate>201807</creationdate><title>Nitric Oxide–Releasing Macromolecular Scaffolds for Antibacterial Applications</title><author>Yang, Lei ; 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Developing novel therapies to combat drug‐resistant bacteria and biofilms infections is a vibrant research area. This review describes recent progress of nitric oxide‐releasing macromolecular scaffolds as antibacterial agents. The correlation between the physicochemical properties of the nitric oxide‐release systems and antimicrobial activity is presented to provide guidance on the rational design of nitric oxide‐based therapies.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29756275</pmid><doi>10.1002/adhm.201800155</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-2212-0658</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibacterial Biofilms Biofilms - drug effects Humans Liposomes - chemistry macromolecular scaffolds Macromolecular Substances - chemistry Macromolecules Molecular Weight Nanoparticles - chemistry Nitrates - chemistry Nitric oxide Nitric Oxide - pharmacokinetics Nitric Oxide Donors - chemistry Nitric Oxide Donors - pharmacology Physicochemical properties Polymers - chemistry rational designs Releasing Scaffolds Surface Properties |
| title | Nitric Oxide–Releasing Macromolecular Scaffolds for Antibacterial Applications |
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